Background
Methods
Initial Study [1]
Results
Baseline characteristic n (row per cent) | Prostaglandin N = 153 | No prostaglandin N = 215 |
p-value |
---|---|---|---|
Maternal age (years) | 30.8 ± 6.2 | 30.1 ± 6.1 | 0.42 |
<30 | 71 (39.4%) | 109 (60.6%) | 0.42 |
≥30 | 82 (43.6%) | 106 (56.4%) | |
Parity | |||
0 | 83 (46.4%) | 96 (53.6%) | 0.07 |
≥1 | 70 (37.0%) | 119 (63.0%) | |
Gestational age at randomization (weeks) | 35.1 ± 1.9 | 35.0 ± 1.9 | 0.88 |
320-336 weeks | 55 (43.7%) | 71 (56.3%) | |
340-366 weeks | 61 (38.9%) | 96 (61.1%) | 0.66 |
370-386 weeks | 37 (43.5%) | 48 (56.5%) | |
Chorionicity on ultrasound | |||
Dichorionic diamniotic | 117 (43.2%) | 154 (56.8%) | 0.18 |
Monochorionic diamniotic | 29 (42.0%) | 40 (58.0%) | |
Unknown | 7 (25.0%) | 21 (75.0%) | |
Birth weight of first twin | 2291.9 ± 402.6 | 2301.9 ± 430.0 | 0.82 |
Birth weight of second twin | 2276.9 ± 449.7 | 2322.8 ± 417.2 | 0.31 |
National perinatal mortality rate | |||
<10/1000 | 116 (45.7%) | 138 (54.3%) | |
≥10/1000 | 37 (32.5%) | 77 (67.5%) | 0.02 |
n (row per cent) | Vaginal delivery for both twins N = 219 | At least one twin delivered by CS N = 149 |
p-value Odds ratio (95% CI) |
---|---|---|---|
Method of induction | 0.99 | ||
PG | 91 (59.5%) | 62 (40.5%) | 1.0 (0.65, 1.5) |
No PG | 128 (59.5%) | 87 (40.5%) | 1 |
Maternal age (years) | 0.01 | ||
<30 | 119 (66.1%) | 61 (33.9%) | 1 |
≥30 | 100 (53.2%) | 88 (46.8%) | 1.7 (1.1, 2.6) |
Parity | <0.0001 | ||
0 | 83 (46.4%) | 96 (53.6%) | 1 |
≥1 | 136 (72.0%) | 53 (28.0%) | 0.33 (0.22, 0.52) |
Chorionicity on ultrasound | 0.73 | ||
Dichorionic | 164 (60.5%) | 107 (39.5%) | 0.75 (0.35, 1.6) |
cMonochorionic | 40 (58.0%) | 29 (42.0%) | 0.84 (0.36, 2.0) |
Unknown | 15 (53.6%) | 13 (46.4%) | 1 |
National perinatal mortality rate | 0.0032 | ||
<10/1000 | 164 (64.6%) | 90 (35.3%) | 1 |
≥10/1000 | 55 (48.3%) | 59 (51.7%) | 2.0 (1.2, 3.1) |
Presentation of twin B at delivery | 0.0012 | ||
Cephalic | 162 (65.3%) | 86 (34.7%) | 0.48 (0.31, 0.75) |
Non-cephalic | 57 (47.5%) | 63 (52.5%) | 1 |
Gestational age at delivery | 0.93 | ||
320-366 weeks | 64 (59.3%) | 44 (40.7%) | 0.86 (0.31, 2.4) |
370-386 weeks | 145 (59.9%) | 97 (40.1%) | 0.84 (0.32, 2.2) |
39+ weeks | 10 (55.6%) | 8 (44.4%) | 1 |
Variables in the final model | Variables not in the final model | ||
---|---|---|---|
Variable |
p-value Odds ratio (95% CI) | Variable |
p-valuea Odds ratio (95% CI) a
|
Maternal age (years) | 0.001 | Method of induction | 0.61 |
<30 | 1 | PG | 0.88 (0.55, 1.4) |
≥30 | 2.2 (1.4, 3.6) | No PG | 1 |
Parity | <0.0001 | Gestational age at randomization | 0.73 |
0 | 1 | 320-336 weeks | 0.89 (0.47, 1.7) |
≥1 | 0.21 (0.13, 0.35) | 340-366 weeks | 1.1 (0.61, 2.0) |
370-386 weeks | 1 | ||
National perinatal mortality rate | <0.0001 | Chorionicity on ultrasound | 0.55 |
<10/1000 | 1 | Dichorionic | 0.70 (0.30, 1.7) |
≥10/1000 | 3.3 (2.0, 5.6) | Monochorionic | 0.92 (0.35, 2.4) |
Unknown | 1 | ||
Presentation of twin B at delivery | 0.0016 | ||
Cephalic | 0.46 (0.28, 0.74) | ||
Non-cephalic | 1 |
Outcome n (column per cent) | Prostaglandin N = 153 | No prostaglandin N = 215 |
p-value Odds ratio (95% CI)a
|
---|---|---|---|
Maternal outcomeb
| |||
No | 137 (89.5%) | 189 (87.9%) | 0.63 |
Yes | 16 (10.5%) | 26 (12.1%) | 0.85 (0.44, 1.6) |
Outcome N, mean ± SD | Prostaglandin | No prostaglandin |
p-value |
Active labor to dilation (hours) | 104, 4.87 ± 4.46 | 142, 4.91 ± 3.05 | 0.94 |
Active labor to delivery (hours) | 132, 6.52 ± 5.49 | 187, 6.6 ± 4.91 | 0.88 |
Delivery to discharge (hours) | 153, 89.0 ± 54.5 | 215, 86.7 ± 44.6 | 0.67 |
Outcome n (column per cent) | Prostaglandin
N = 304 | No prostaglandin
N = 428 |
p-value Odds ratio (95% CI)a
|
Neonatal outcomec
| |||
No | 298 (98.0%) | 418 (97.7%) | 0.74 |
Yes | 6 (2.0%) | 10 (2.3%) | 0.86 (0.37, 2.0) |