Skip to main content

01.03.2018 | Allergies and the Environment (M Hernandez, Section Editor) | Ausgabe 3/2018

Current Allergy and Asthma Reports 3/2018

The Effect of Inhalant Organic Dust on Bone Health

Current Allergy and Asthma Reports > Ausgabe 3/2018
Joseph M. Carrington, Jill A. Poole
Wichtige Hinweise
This article is part of the Topical Collection on Allergies and the Environment


Purpose of Review

Agriculture remains a major economic sector globally, and workers experience high rates of chronic inflammatory lung and musculoskeletal diseases. Whereas obstructive pulmonary diseases are known risk factors for bone loss, the underlying relationship between lung inflammation and bone health is not well known.

Recent Findings

An agriculture organic dust extract inhalation animal model has recently linked lung injury-induced inflammation to systemic bone loss. This process is dependent upon lipopolysaccharide and the toll-like receptor 4 (TLR4) signaling pathway. Downstream systemic interleukin-6 is a key mediator that subsequently activates osteoclastogenesis. Age is a host factor that impacted bone disease with younger mice demonstrating increased susceptibility to bone loss following inhalant exposures as compared to older mice. Supplemental dietary vitamin D was shown to prevent organic dust-induced bone loss, but not lung disease, in animals.


Recent animal studies provide new mechanistic insight into the lung-bone inflammatory axis. Host factors, diet, and lipopolysaccharide/TLR4 signaling pathways play a significant role in explaining how inhalant organic dust exposures impact bone health. These investigations might lead to specific targeted therapeutic approaches.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Über diesen Artikel

Weitere Artikel der Ausgabe 3/2018

Current Allergy and Asthma Reports 3/2018 Zur Ausgabe

Allergies and the Environment (M Hernandez, Section Editor)

Impact of Particulate Air Pollution on Cardiovascular Health

Allergies and the Environment (M Hernandez, Section Editor)

Indoor Environmental Interventions and their Effect on Asthma Outcomes

Neu im Fachgebiet HNO

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update HNO und bleiben Sie gut informiert – ganz bequem per eMail.