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01.12.2014 | Research | Ausgabe 1/2014 Open Access

Molecular Autism 1/2014

The effect of intranasal oxytocin versus placebo treatment on the autonomic responses to human sounds in autism: a single-blind, randomized, placebo-controlled, crossover design study

Zeitschrift:
Molecular Autism > Ausgabe 1/2014
Autoren:
I-Fan Lin, Makio Kashino, Haruhisa Ohta, Takashi Yamada, Masayuki Tani, Hiromi Watanabe, Chieko Kanai, Taisei Ohno, Yuko Takayama, Akira Iwanami, Nobumasa Kato
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​2040-2392-5-20) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

IL conceived of the study, participated in its design, analyzed the data, and drafted the manuscript. MK participated in its design and helped to draft the manuscript. HO, TY, MT, HW, CK, TO, YT, AI, and NK helped to conduct the experiment, collect the data, and revise the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Many individuals with autism spectrum disorders (ASD) have difficulty with verbal communication, which might be due to a lack of spontaneous orientation toward social auditory stimuli. Previous studies have shown that a single dose of oxytocin improves speech comprehension in autism. The primary aim of this study was to investigate whether the orientation behaviors toward human sounds are different for neurotypical (NT) adults and adults with ASD and whether oxytocin has an effect on their orientation behaviors toward human sounds.

Methods

This was a randomized, placebo-controlled, within-subject, crossover design study of intranasal oxytocin versus placebo in 13 NT adults and 16 adults with ASD. Subjects were randomized to 24 IU intranasal oxytocin or placebo on different days, and they were blind to the treatment. The participants then listened passively to human and non-human affective sounds while their skin conductance responses (SCRs) and the changes in peripheral blood vessel constriction were monitored as an indicator of spontaneous orientation. The monitored data were analyzed by a mixed-design ANOVA.

Results

Oxytocin enhanced the difference between the SCRs to human and non-human sounds in both the NT and ASD groups (F(1,56) = 6.046, p = 0.017). Further correlation coefficient analysis showed significant correlations between this SCR difference and the scores in the autism spectrum quotient ‘attention to detail’ and ‘social skill’ subscales and interpersonal reactivity index and social functioning scale in the ASD group. Oxytocin was well tolerated, and no serious adverse effects were reported.

Conclusions

The difference in SCRs implies that oxytocin nasal spray may enhance orientation behaviors toward human sounds in the presence of other environmental sounds in both ASD and NT adults.

Trial registration

UMIN-CTR Clinical Trial, Unique trial number: UMIN000005809
Zusatzmaterial
Additional file 1: Table S1: Evaluation of valence and arousal levels of the sounds used in the experiment (Bradley and Lang, 2007): mean (standard deviation) of the evaluations across subjects. Figure S1. Pre-stimulus SCLs across 29 participants for the 25 auditory stimuli presented in the experiment in the oxytocin session and the placebo session. The error bars are standard errors. (DOCX 20 KB)
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Authors’ original file for figure 1
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Authors’ original file for figure 2
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Authors’ original file for figure 3
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Literatur
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