Background
Methods
Study design
Participants
Ethics statement
Vaccines
Statistical analysis
Results
Study participants
Characteristics | Group 1 | Group 2 | Group 3 | Group 4 | Group 5 |
---|---|---|---|---|---|
N | 109 | 125 | 127 | 124 | 124 |
Age—daysa | 72.18 ± 8.93 | 73.00 ± 8.81 | 72.59 ± 8.81 | 72.12 ± 8.09 | 73.83 ± 7.89 |
Sex—no. (%) | |||||
Male | 49 (44.95) | 68 (54.40) | 65 (51.18) | 61 (49.19) | 63 (50.81) |
Female | 60 (55.05) | 57 (45.60) | 62 (48.82) | 63 (50.81) | 61 (49.19) |
Group | N | Type | Positive participants | Positive rate (%) | GMT | Participants with different titers (1:) | ||
---|---|---|---|---|---|---|---|---|
< 8 | 8 ~ < 32 | ≥32 | ||||||
1 | 109 | I | 82 | 75.23 | 17.57 | 27 | 47 | 35 |
II | 49 | 44.95 | 8.39 | 60 | 33 | 16 | ||
III | 29 | 26.61 | 6.13 | 80 | 20 | 9 | ||
2 | 125 | I | 98 | 78.40 | 18.44 | 27 | 50 | 48 |
II | 43 | 34.40 | 6.73 | 82 | 30 | 13 | ||
III | 23 | 18.40 | 5.33 | 102 | 19 | 4 | ||
3 | 127 | I | 90 | 70.87 | 17.99 | 37 | 39 | 51 |
II | 46 | 36.22 | 6.69 | 81 | 35 | 11 | ||
III | 21 | 16.54 | 5.59 | 106 | 14 | 7 | ||
4 | 124 | I | 96 | 77.42 | 21.21 | 28 | 40 | 56 |
II | 47 | 37.90 | 6.44 | 77 | 42 | 5 | ||
III | 33 | 26.61 | 6.41 | 91 | 23 | 10 | ||
5 | 124 | I | 95 | 76.61 | 19.15 | 29 | 45 | 50 |
II | 46 | 37.10 | 6.92 | 78 | 36 | 10 | ||
III | 31 | 25.00 | 5.79 | 93 | 25 | 6 |
Maternal antibody dichotomy
Group | Type | GMT (95% CI) | GMI (95% CI) | Seroconversion rate (%) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Maternal negative | Maternal positive | P | Maternal negative | Maternal positive | P | Maternal negative | Maternal positive | P | ||
1 | I | 5086.27 (3909.17–6617.80) | 3191.30 (2619.36–3888.12) | 0.006 | 1271.57 (977.29–1654.45) | 111.56 (81.88–152.00) | < 0.001 | 100.00 | 98.78 | 1.000 |
II | 878.35 (704.86–1094.54) | 505.09 (381.51–668.70) | 0.002 | 219.59 (176.21–273.63) | 24.32 (15.51–38.11) | < 0.001 | 100.00 | 85.71 | 0.008 | |
III | 1142.55 (961.97–1357.03) | 619.06 (386.93–990.46) | 0.017 | 285.64 (240.49–339.26) | 31.13 (15.56–62.31) | < 0.001 | 100.00 | 82.76 | 0.001 | |
2 | I | 4231.17 (3210.69–5576.00) | 3139.05 (2554.03–3858.08) | 0.084 | 1057.79 (802.67–1394.00) | 111.75 (88.66–154.84) | < 0.001 | 100.00 | 98.98 | 1.000 |
II | 900.64 (767.91–1056.30) | 550.11 (405.38–746.52) | 0.005 | 225.16 (191.98–264.07) | 30.25 (18.80–48.67) | < 0.001 | 100.00 | 90.70 | 0.023 | |
III | 1036.17 (880.40–1219.50) | 564.94 (372.86–855.96) | 0.003 | 259.04 (220.10–304.87) | 29.60 (12.55–69.80) | < 0.001 | 100.00 | 86.96 | 0.006 | |
3 | I | 6187.48 (4563.25–8389.85) | 4131.94 (3411.86–5003.98) | 0.025 | 1546.87 (1140.81–2097.46) | 123.79 (86.99–176.17) | < 0.001 | 100.00 | 96.67 | 0.556 |
II | 1018.74 (873.77–1187.76) | 711.84 (567.01–893.67) | 0.008 | 254.69 (218.44–296.94) | 43.10 (29.34–63.29) | < 0.001 | 100.00 | 95.65 | 0.129 | |
III | 1207.23 (1025.79–1420.76) | 835.86 (475.52–1469.29) | 0.206 | 301.81 (256.45–355.19) | 27.66 (10.49–72.96) | < 0.001 | 100.00 | 85.71 | 0.004 | |
4 | I | 5830.71 (4431.70–7671.36) | 3051.49 (2523.95–3689.29) | 0.001 | 1457.68 (1107.92–1917.84) | 88.46 (64.22–121.86) | < 0.001 | 100.00 | 95.83 | 0.574 |
II | 273.86 (225.62–332.42) | 228.21 (171.48–303.71) | 0.276 | 68.47 (56.41–83.10) | 16.22 (11.10–23.71) | < 0.001 | 100.00 | 89.36 | 0.014 | |
III | 675.19 (561.49–811.92) | 260.20 (178.35–379.61) | < 0.001 | 168.80 (140.37–202.98) | 11.08 (6.12–20.05) | < 0.001 | 100.00 | 84.85 | 0.001 | |
5 | I | 546.12 (408.61–729.91) | 660.98 (549.64–794.86) | 0.306 | 136.53 (102.15–182.48) | 19.40 (14.51–25.95) | < 0.001 | 100.00 | 88.42 | 0.122 |
II | 209.42 (176.39–248.63) | 122.10 (97.10–153.55) | < 0.001 | 52.35 (44.10–62.16) | 7.62 (5.36–10.82) | < 0.001 | 100.00 | 78.26 | < 0.001 | |
III | 501.89 (417.41–603.47) | 567.52 (397.01–811.27) | 0.518 | 125.47 (104.35–150.87) | 36.94 (24.12–56.56) | < 0.001 | 100.00 | 100.00 | – |