The effect of meconium-stained amniotic fluid on perinatal outcome in pregnancies complicated by preterm premature rupture of membranes
- 17.04.2020
- Maternal-Fetal Medicine
Erschienen in:
- Verfasst von
- Avital Wertheimer
- Asaf Shemer
- Eran Hadar
- Alexandra Berezowsky
- Arnon Wiznitzer
- Eyal Krispin
- Erschienen in
- Archives of Gynecology and Obstetrics | Ausgabe 5/2020
Abstract
Purpose
To determine whether meconium-stained amniotic fluid (MSAF) encountered in pregnancies complicated by preterm premature rupture of membranes (PPROM) is associated with adverse maternal and perinatal outcome.
Methods
A retrospective cohort study of all singleton pregnancies with PPROM and MSAF who delivered in a tertiary hospital at 24 + 0–36 + 6 weeks of gestation between 2007 and 2017. Women with PPROM–MSAF (study group) were compared to women with PPROM and clear amniotic fluid (control group). Controls were matched to cases according to age, gravidity, parity and gestational age at delivery in a 3:1 ratio. Primary outcome was defined as neonatal intensive care unit admission. Secondary outcomes were neonatal adverse outcomes, chorioamnionitis and placental abruption diagnosed clinically or by placental cultures and histology.
Results
Seventy-five women comprised the study group and were matched to 225 women representing the control group. A significantly higher rate of neonatal intensive care unit admissions was noted in the study group compared to controls (61.3% vs. 45.7%, p = 0.03). Multivariate analysis demonstrated that MSAF is an independent risk factor for neonatal intensive care unit admission (adjusted OR = 2.82, 95% CI 1.39–5.75, p = 0.004). MSAF was found to be associated to higher rates of cesarean and operative vaginal deliveries (30.7% vs. 24.4% and 5.3% vs. 2.7%, p = 0.057, respectively) as well as to chorioamnionitis and placental abruption (33.3% vs. 19.3%, p = 0.034 and 16.0% vs. 7.7%, p = 0.021, respectively).
Conclusion
MSAF is associated with higher frequencies of adverse perinatal outcome when compared to clear amniotic fluid in pregnancies complicated by PPROM.
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- Titel
- The effect of meconium-stained amniotic fluid on perinatal outcome in pregnancies complicated by preterm premature rupture of membranes
- Verfasst von
-
Avital Wertheimer
Asaf Shemer
Eran Hadar
Alexandra Berezowsky
Arnon Wiznitzer
Eyal Krispin
- Publikationsdatum
- 17.04.2020
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Archives of Gynecology and Obstetrics / Ausgabe 5/2020
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711 - DOI
- https://doi.org/10.1007/s00404-020-05541-2
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