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01.09.2009 | Original Article | Ausgabe 5/2009

Langenbeck's Archives of Surgery 5/2009

The effectiveness of FloSeal® matrix hemostatic agent in thyroid surgery: a prospective, randomized, control study

Zeitschrift:
Langenbeck's Archives of Surgery > Ausgabe 5/2009
Autoren:
Mario Testini, Rinaldo Marzaioli, Germana Lissidini, Agostino Lippolis, Francesco Logoluso, Angela Gurrado, Domenica Lardo, Elisabetta Poli, Giuseppe Piccinni

Abstract

Background

The objective of this study was to compare the effectiveness of FloSeal® matrix hemostatic agent with hemostatic surgical procedures and Tabotamp® in thyroid surgery.

Methods

One hundred fifty-five consecutive total thyroidectomy patients were recruited at our institution between January 2005 and December 2007. Exclusion criteria were applied. Patients were randomized to one of three hemostatic approaches: 49 received surgical procedures only, and 52 received oxidized regenerated cellulose patch (Tabotamp Fibrillar 2.5 × 5 cm) and 54 FloSeal (5,000 U/5 mL). The same surgeon performed all operations.

Results

Mean operating time was reduced in the FloSeal group (105 min) vs. surgical (133 min, p = 0.02) and vs. Tabotamp (122 min, p = 0.0003). Also, wound drain removal occurred earlier with FloSeal (p = 0.006 vs. surgical; p = 0.008 vs. Tabotamp) resulting in shorter postoperative hospital stay in the FloSeal group (p = 0.02 vs. surgical; p = 0.002 vs. Tabotamp).

Conclusions

FloSeal matrix is an effective additional agent to conventional haemostatic procedures in thyroid surgery.

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