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Erschienen in: Indian Journal of Gastroenterology 1/2019

13.03.2019 | Original Article

The effectiveness of mindfulness meditation in relief of symptoms of depression and quality of life in patients with gastroesophageal reflux disease

verfasst von: Suhas Chandran, Rajesh Raman, M. Kishor, H. P. Nandeesh

Erschienen in: Indian Journal of Gastroenterology | Ausgabe 1/2019

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Abstract

Background

The role of psychological comorbidities in patients with gastroesophageal reflux disease (GERD), a common condition, still remains incompletely understood. Depression may intensify the symptoms and lower quality of life in these patients. In this study, we looked at the effectiveness of mindfulness-based stress reduction (MBSR) in relieving the symptoms of depression and the health-related quality of life of these patients.

Methods

A longitudinal, interventional open-label study was carried out on 60 patients with GERD and 60 controls. Zung Self-Rating Depression Scale (ZSDS) was used for assessing depression before and after the intervention. The GERD-Health-Related Quality of Life (GERD-HRQL) questionnaire was used to assess the health-related quality of life and the Freiburg Mindfulness Inventory (FMI) to quantify the amount of mindfulness over the study period. The correlation between the above variables was analyzed.

Result

Compared with the group not receiving MBSR, the group receiving MBSR showed a greater decrease in the levels of depression indicated by changes in the ZSDS (p < 0.001). According to the GERD-HRQL questionnaire, mental health and social functioning significantly correlated with symptoms of depression and reduction in the levels of distress and in the improvement in health-related quality of life were greater in the group receiving MBSR (p < 0.001).

Conclusion

Depressive symptoms adversely influence GERD, reducing the overall quality of life. MBSR can be an effective modality in the alleviation of these symptoms and in reduction in the levels of distress in GERD patients.
Literatur
1.
Zurück zum Zitat Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–20.CrossRefPubMed Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–20.CrossRefPubMed
2.
Zurück zum Zitat Spechler SJ. Clinical manifestations and esophageal complications of GERD. Am J Med Sci. 2003;326:279–84.CrossRefPubMed Spechler SJ. Clinical manifestations and esophageal complications of GERD. Am J Med Sci. 2003;326:279–84.CrossRefPubMed
3.
Zurück zum Zitat El-Serag HB, Sweet S, Winchester CC, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014;63:871–80.CrossRefPubMed El-Serag HB, Sweet S, Winchester CC, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014;63:871–80.CrossRefPubMed
5.
Zurück zum Zitat Bhatia SJ, Reddy DN, Ghoshal UC, et al. Epidemiology and symptom profile of gastroesophageal reflux in the Indian population: report of the Indian Society of Gastroenterology Task Force. Indian J Gastroenterol. 2011;30:118–27. Bhatia SJ, Reddy DN, Ghoshal UC, et al. Epidemiology and symptom profile of gastroesophageal reflux in the Indian population: report of the Indian Society of Gastroenterology Task Force. Indian J Gastroenterol. 2011;30:118–27.
6.
Zurück zum Zitat Rai RR, Gangadhar A, Mayabhate MM. Clinical profiling of patients with acid peptic disorders (APD) in India: a cross-sectional survey of clinicians. Int J Basic Clin Pharmacol. 2016;6:194–202.CrossRef Rai RR, Gangadhar A, Mayabhate MM. Clinical profiling of patients with acid peptic disorders (APD) in India: a cross-sectional survey of clinicians. Int J Basic Clin Pharmacol. 2016;6:194–202.CrossRef
8.
Zurück zum Zitat Engel GL. The need for a new medical model: a challenge for biomedicine. Science. 1977;196:129–36.CrossRefPubMed Engel GL. The need for a new medical model: a challenge for biomedicine. Science. 1977;196:129–36.CrossRefPubMed
9.
Zurück zum Zitat Yang XJ, Jiang HM, Hou XH, Song J. Anxiety and depression in patients with gastroesophageal reflux disease and their effect on quality of life. World J Gastroenterol. 2015;21:4302–9.CrossRefPubMedPubMedCentral Yang XJ, Jiang HM, Hou XH, Song J. Anxiety and depression in patients with gastroesophageal reflux disease and their effect on quality of life. World J Gastroenterol. 2015;21:4302–9.CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Li YM, Du J, Zhang H, Yu CH. Epidemiological investigation in outpatients with symptomatic gastroesophageal reflux from the Department of Medicine in Zhejiang Province, east China. J Gastroenterol Hepatol. 2008;23:283–9.CrossRefPubMed Li YM, Du J, Zhang H, Yu CH. Epidemiological investigation in outpatients with symptomatic gastroesophageal reflux from the Department of Medicine in Zhejiang Province, east China. J Gastroenterol Hepatol. 2008;23:283–9.CrossRefPubMed
11.
Zurück zum Zitat Lee YC, Wang HP, Chiu HM, et al. Comparative analysis between psychological and endoscopic profiles in patients with gastroesophageal reflux disease: a prospective study based on screening endoscopy. J Gastroenterol Hepatol. 2006;21:798–804.CrossRefPubMed Lee YC, Wang HP, Chiu HM, et al. Comparative analysis between psychological and endoscopic profiles in patients with gastroesophageal reflux disease: a prospective study based on screening endoscopy. J Gastroenterol Hepatol. 2006;21:798–804.CrossRefPubMed
12.
Zurück zum Zitat Jansson C, Nordenstedt H, Wallander M, et al. A population-based study showing an association between gastroesophageal reflux disease and sleep problems. Clin Gastroenterol Hepatol. 2009;7:960–5.CrossRefPubMed Jansson C, Nordenstedt H, Wallander M, et al. A population-based study showing an association between gastroesophageal reflux disease and sleep problems. Clin Gastroenterol Hepatol. 2009;7:960–5.CrossRefPubMed
13.
Zurück zum Zitat DeVault KR, Castell DO, American College of Gastroenterology. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol. 2005;100:190–200.CrossRefPubMed DeVault KR, Castell DO, American College of Gastroenterology. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol. 2005;100:190–200.CrossRefPubMed
14.
Zurück zum Zitat Fass R. Approach to refractory gastroesophageal reflux disease in adults; Topic 2239, Version 16.0; www.uptodate.com; topic last updated: Jun 07. 2016. Fass R. Approach to refractory gastroesophageal reflux disease in adults; Topic 2239, Version 16.0; www.​uptodate.​com; topic last updated: Jun 07. 2016.
15.
Zurück zum Zitat El-Serag H, Becher A, Jones R. Systematic review: persistent reflux symptoms on proton pump inhibitor therapy in primary care and community studies. Aliment Pharmacol Ther. 2010;32:720–37.CrossRefPubMed El-Serag H, Becher A, Jones R. Systematic review: persistent reflux symptoms on proton pump inhibitor therapy in primary care and community studies. Aliment Pharmacol Ther. 2010;32:720–37.CrossRefPubMed
16.
Zurück zum Zitat Fass R, Shapiro M, Dekel R, Sewell J. Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease–where next? Aliment Pharmacol Ther. 2005;22:79–94.CrossRefPubMed Fass R, Shapiro M, Dekel R, Sewell J. Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease–where next? Aliment Pharmacol Ther. 2005;22:79–94.CrossRefPubMed
17.
Zurück zum Zitat Bhatia V, Tandon RK. Stress and the gastrointestinal tract. J Gastroenterol Hepatol. 2005;20:332–9.CrossRefPubMed Bhatia V, Tandon RK. Stress and the gastrointestinal tract. J Gastroenterol Hepatol. 2005;20:332–9.CrossRefPubMed
18.
Zurück zum Zitat Konturek PC, Brzozowski T, Konturek SJ. Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. J Physiol Pharmacol. 2011;62:591–9.PubMed Konturek PC, Brzozowski T, Konturek SJ. Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. J Physiol Pharmacol. 2011;62:591–9.PubMed
19.
Zurück zum Zitat Kamolz T, Pointner R. Gastroesophageal reflux disease. Minerva Gastroenterol Dietol. 2004;50:261–8.PubMed Kamolz T, Pointner R. Gastroesophageal reflux disease. Minerva Gastroenterol Dietol. 2004;50:261–8.PubMed
20.
Zurück zum Zitat Hofmann SG, Sawyer AT, Witt AA, Oh D. The effect of mindfulness-based therapy on anxiety and depression: a meta-analytic review. J Consult Clin Psychol. 2010;78:169–83.CrossRefPubMedPubMedCentral Hofmann SG, Sawyer AT, Witt AA, Oh D. The effect of mindfulness-based therapy on anxiety and depression: a meta-analytic review. J Consult Clin Psychol. 2010;78:169–83.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Hölzel BK, Lazar SW, Gard T, Schuman-Olivier Z, Vago DR, Ott U. How does mindfulness meditation work? Proposing mechanisms of action from a conceptual and neural perspective. Perspect Psychol Sci. 2011;6:537–59.CrossRefPubMed Hölzel BK, Lazar SW, Gard T, Schuman-Olivier Z, Vago DR, Ott U. How does mindfulness meditation work? Proposing mechanisms of action from a conceptual and neural perspective. Perspect Psychol Sci. 2011;6:537–59.CrossRefPubMed
22.
Zurück zum Zitat Kabat-Zinn J, Hanh TN. Full Catastrophe Living: Using the Wisdom of Your Body and Mind to Face Stress, Pain, and Illness. Delta Trade Paperbacks, 1990. Kabat-Zinn J, Hanh TN. Full Catastrophe Living: Using the Wisdom of Your Body and Mind to Face Stress, Pain, and Illness. Delta Trade Paperbacks, 1990.
23.
Zurück zum Zitat Zung W. A rating instrument for anxiety disorders. Psychosomatics. 1971;12:371–9. Zung W. A rating instrument for anxiety disorders. Psychosomatics. 1971;12:371–9.
24.
Zurück zum Zitat Walach H, Buchheld N, Buttenmuller V, Kleinknecht N, Schmidt S. Measuring mindfulness--the Freiburg Mindfulness Inventory (FMI). Personal Individ Differ. 2006;40:1543–55.CrossRef Walach H, Buchheld N, Buttenmuller V, Kleinknecht N, Schmidt S. Measuring mindfulness--the Freiburg Mindfulness Inventory (FMI). Personal Individ Differ. 2006;40:1543–55.CrossRef
25.
Zurück zum Zitat Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59 Suppl 20:22–33. Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59 Suppl 20:22–33.
26.
Zurück zum Zitat Velanovich V. The development of the GERD-HRQL symptom severity instrument. Dis Esophagus. 2007;20:130–4.CrossRefPubMed Velanovich V. The development of the GERD-HRQL symptom severity instrument. Dis Esophagus. 2007;20:130–4.CrossRefPubMed
27.
28.
Zurück zum Zitat Spechler SJ. Epidemiology and natural history of gastro-oesophageal reflux disease. Digestion. 1992;51 Suppl 1:24–9. Spechler SJ. Epidemiology and natural history of gastro-oesophageal reflux disease. Digestion. 1992;51 Suppl 1:24–9.
29.
Zurück zum Zitat Wienbeck M, Babnert J. Epidemiology of reflux disease and reflux esophagitis. Scand J Gastroenterol. 1989;24 Suppl 156:7–13. Wienbeck M, Babnert J. Epidemiology of reflux disease and reflux esophagitis. Scand J Gastroenterol. 1989;24 Suppl 156:7–13.
30.
Zurück zum Zitat Stanghellini V. Three-month prevalence rates of gastrointestinal symptoms and the influence of demographic factors: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST). Scand J Gastroenterol Suppl. 1999;231:20–8.CrossRefPubMed Stanghellini V. Three-month prevalence rates of gastrointestinal symptoms and the influence of demographic factors: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST). Scand J Gastroenterol Suppl. 1999;231:20–8.CrossRefPubMed
31.
Zurück zum Zitat Locke GR, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112:448–56.CrossRef Locke GR, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112:448–56.CrossRef
32.
Zurück zum Zitat Wiklund I, Carlsson R, Wiklund I, Carlsson R, Carlsson J, Glise H. Psychological factors as a predictor of treatment response in patients with heartburn: a pooled analysis of clinical trials. Scand J Gastroenterol. 2006;41:288–93.CrossRefPubMed Wiklund I, Carlsson R, Wiklund I, Carlsson R, Carlsson J, Glise H. Psychological factors as a predictor of treatment response in patients with heartburn: a pooled analysis of clinical trials. Scand J Gastroenterol. 2006;41:288–93.CrossRefPubMed
33.
Zurück zum Zitat Kessing BF, Bredenoord AJ, Saleh CM, Smout AJ. Effects of anxiety and depression in patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2015;13:1089–95.CrossRefPubMed Kessing BF, Bredenoord AJ, Saleh CM, Smout AJ. Effects of anxiety and depression in patients with gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2015;13:1089–95.CrossRefPubMed
34.
Zurück zum Zitat Ronkainen J, Aro P, Storskrubb T, et al. Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population: the Kalixanda study. Aliment Pharmacol Ther. 2006;23:1725–33.CrossRefPubMed Ronkainen J, Aro P, Storskrubb T, et al. Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population: the Kalixanda study. Aliment Pharmacol Ther. 2006;23:1725–33.CrossRefPubMed
35.
Zurück zum Zitat Garland EL, Gaylord SA, Palsson O, Faurot K, Douglas Mann J, Whitehead WE. Therapeutic mechanisms of a mindfulness-based treatment for IBS: effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations. J Behav Med. 2012;35:591–602.CrossRefPubMed Garland EL, Gaylord SA, Palsson O, Faurot K, Douglas Mann J, Whitehead WE. Therapeutic mechanisms of a mindfulness-based treatment for IBS: effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations. J Behav Med. 2012;35:591–602.CrossRefPubMed
36.
Zurück zum Zitat Labelle LE, Campbell TS, Carlson LE. Mindfulness-based stress reduction in oncology: evaluating mindfulness and rumination as mediators of change in depressive symptoms. Mindfulness. 2010;1:28–40.CrossRef Labelle LE, Campbell TS, Carlson LE. Mindfulness-based stress reduction in oncology: evaluating mindfulness and rumination as mediators of change in depressive symptoms. Mindfulness. 2010;1:28–40.CrossRef
Metadaten
Titel
The effectiveness of mindfulness meditation in relief of symptoms of depression and quality of life in patients with gastroesophageal reflux disease
verfasst von
Suhas Chandran
Rajesh Raman
M. Kishor
H. P. Nandeesh
Publikationsdatum
13.03.2019
Verlag
Springer India
Erschienen in
Indian Journal of Gastroenterology / Ausgabe 1/2019
Print ISSN: 0254-8860
Elektronische ISSN: 0975-0711
DOI
https://doi.org/10.1007/s12664-019-00940-z

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