Communicated by Michael Lindinger.
The online version of this article (doi:10.1007/s00421-014-2854-5) contains supplementary material, which is available to authorized users.
Studies utilizing beta-hydroxy-beta-methylbutyrate (HMB) supplementation in trained populations are limited. No long-term studies utilizing HMB free acid (HMB-FA) have been conducted. Therefore, we investigated the effects of 12 weeks of HMB-FA supplementation on skeletal muscle hypertrophy, body composition, strength, and power in trained individuals. We also determined the effects of HMB-FA on muscle damage and performance during an overreaching cycle.
A three-phase double-blind, placebo- and diet-controlled randomized intervention study was conducted. Phase 1 was an 8-week-periodized resistance-training program; Phase 2 was a 2-week overreaching cycle; and Phase 3 was a 2-week taper. Muscle mass, strength, and power were examined at weeks 0, 4, 8, and 12 to assess the chronic effects of HMB-FA; and assessment of these, as well as cortisol, testosterone, and creatine kinase (CK) was performed at weeks 9 and 10 of the overreaching cycle.
HMB-FA resulted in increased total strength (bench press, squat, and deadlift combined) over the 12-week training (77.1 ± 18.4 vs. 25.3 ± 22.0 kg, p < 0.001); a greater increase in vertical jump power (991 ± 168 vs. 630 ± 167 W, p < 0.001); and increased lean body mass gain (7.4 ± 4.2 vs. 2.1 ± 6.1 kg, p < 0.001) in HMB-FA- and placebo-supplemented groups, respectively. During the overreaching cycle, HMB-FA attenuated increases in CK (−6 ± 91 vs. 277 ± 229 IU/l, p < 0.001) and cortisol (−0.2 ± 2.9 vs. 4.5 ± 1.7 μg/dl, p < 0.003) in the HMB-FA- and placebo-supplemented groups, respectively.
These results suggest that HMB-FA enhances hypertrophy, strength, and power following chronic resistance training, and prevents decrements in performance following the overreaching.
Bruckbauer A, Zemel MB, Thorpe T, Akula MR, Stuckey AC, Osborne D, Martin EB, Kennel S, Wall JS (2012) Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond) 9:77 CrossRef
Hoffman JR, Cooper J, Wendell M, Im J, Kang J (2004) Effects of beta-hydroxy beta-methylbutyrate on power performance and indices of muscle damage and stress during high-intensity training. J Strength Cond Res 18(4):747–752 PubMed
Hunga W, Liub T-H, Chenc C-Y, Chang C-K (2010) Effect of [beta]-hydroxy-[beta]-methylbutyrate supplementation during energy restriction in female judo athletes. J Exerc Sci Fit 8:50–53 CrossRef
Laurent CM, Green JM, Bishop PA, Sjokvist J, Schumacker RE, Curtner-Smith M (2011) A practical approach to monitoring recovery: development of a perceived recovery status scale. J Strength Con Res 25:620–628 CrossRef
Lowery RP, Duncan NM, Loenneke JP, Sikorski EM, Naimo MA, Brown LE, Wilson FG, Wilson JM (2012) The effects of potentiating stimuli intensity under varying rest periods on vertical jump performance and power. J Strength Con Res 26:3320–3325 CrossRef
Monteiro AG, Aoki MS, Evangelista AL, Alveno DA, Monteiro GA, Picarro Ida C, Ugrinowitsch C (2009) Nonlinear periodization maximizes strength gains in split resistance training routines. J Strength Con Res 23:1321–1326 CrossRef
Nissen S, Sharp R, Ray M, Rathmacher JA, Rice D, Fuller JC Jr, Connelly AS, Abumrad N (1996) Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training. J Appl Physiol 81:2095–2104 PubMed
Robbins DW, Docherty D (2005) Effect of loading on enhancement of power performance over three consecutive trials. J Strength Con Res 19:898–902
Sikorski EM, Wilson JM, Lowery RP, Joy JM, Laurant CM, S MCW, Hesson D, Naimo MA, Averbuch B, Gilchrist P (2013) Changes in perceived recovery status scale following high-volume muscle damaging resistance exercise. J Strength Con Res 27:2079–2085
Slater G, Jenkins D, Logan P, Lee H, Vukovich M, Rathmacher JA, Hahn AG (2001) Beta-hydroxy-beta-methylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained men. Int J Sport Nutr Exerc Metab 11:384–396 PubMed
Smith JC, Fry AC, Weiss LW, Li Y, Kinzey SJ (2001) The effects of high-intensity exercise on a 10-second sprint cycle test. J Strength Con Res 15:344–348
Stancliffe RA, Zemel MB (2012) Role of β-hydroxy-β-methylbutyrate (HMB) in leucine stimulation of muscle mitochondrial biogenesis. FASEB J 26:251–256
Thomson JS, Watson PE, Rowlands DS (2009) Effects of nine weeks of beta-hydroxy-beta- methylbutyrate supplementation on strength and body composition in resistance trained men. J Strength Con Res 23:827–835 CrossRef
Turner A (2011) The science and practice of periodization: a brief review. Strength Cond J 33:34–46
van Someren KA, Edwards AJ, Howatson G (2005) Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man. Int J Sport Nutr Exerc Metab 15:413–424 PubMed
Wilkinson DJ, Hossain T, Hill DS, Phillips BE, Crossland H, Williams J, Loughna P, Churchward-Venne TA, Breen L, Phillips SM, Etheridge T, Rathmacher JA, Smith K, Szewczyk NJ, Atherton PJ (2013) Effects of Leucine and its metabolite, beta-hydroxy-beta-methylbutyrate (HMB) on human skeletal muscle protein metabolism. J Physiol 591:2911–2923 PubMedCentralPubMed
Wilson GJ, Wilson JM, Manninen AH (2008) Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: a review. J Nutr Metab (Lond) 5:1 CrossRef
Wilson JM, Duncan NM, Marin PJ, Brown LE, Loenneke JP, Wilson SM, Jo E, Lowery RP, Ugrinowitsch C (2012) Meta-analysis of post activation potentiation and power: effects of conditioning activity, volume, gender, rest periods, and training status. J Strength Con Res 27:854–859 CrossRef
Wilson JM, Fitschen PJ, Campbell B, Wilson GJ, Zanchi N, Taylor L, Wilborn C, Kalman DS, Stout JR, Hoffman JR, Ziegenfuss TN, Lopez HL, Kreider RB, Smith-Ryan AE, Antonio J (2013a) International society of sports nutrition position stand: beta-hydroxy-beta-methylbutyrate (HMB). J Int Soc Sports Nutr 10:6 PubMedCentralPubMedCrossRef
Wilson JM, Lowery RP, Joy JM, Walters JA, Baier SM, Fuller JC, Stout JR, Norton LE, Sikorski EM, Wilson SM, Duncan NM, Zanchi NE, Rathmacher J (2013b) Beta-hydroxy-beta-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men. Br J Nutr 110:538–544 PubMedCrossRef
- The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: a randomized, double-blind, placebo-controlled study
Jacob M. Wilson
Ryan P. Lowery
Jordan M. Joy
J. C. Andersen
Stephanie M. C. Wilson
Jeffrey R. Stout
John C. Fuller
Shawn M. Baier
Marshall A. Naimo
- Springer Berlin Heidelberg