The effects of acute and elective cardiac surgery on the anxiety traits of patients with Marfan syndrome

Marfan syndrome is a rare, autosomal dominant genetic disease with the prevalence of 1:3000–1:5000, affecting connective tissue [1]. The life expectancy and quality of life of patients with Marfan syndrome are mainly determined by the presence and severity of cardiovascular lesions, such as annuloaortic ectasia, aneurysm and dissection [2, 3]. Marfan syndrome implies vascular events [4], which can be life-threatening and thus result in permanent anxiety for the patients. According to the 2012 ESC/EACTS guidelines [5], depending on the diameter of the aorta, prophylactic aortic-root replacement surgery is strongly recommended for the prevention of aortic dissection and rupture in patients diagnosed with Marfan syndrome.

There are several publications regarding aortic-root reconstruction surgeries carried out in Marfan patients. Gott and colleagues [6] reported on surgery of 675 patients (30% female, 70% male) with Marfan syndrome. In this group, 30% of the patients had had earlier aortic dissection. Shimizu and colleagues [7] performed 55 cardiac surgeries between 1987 and 2010 (34% female, 66% male), from which 50% had previous aortic dissection. In 2003 Yetman and colleagues [8] examined 70 Marfan patients (49% female, 51% male). Forty-nine percent of them had family history with the disease, and sudden cardiac death occurred among 27% of the patients. In this group 8% of the patients had previous surgery.

There are only few studies in the literature regarding the psychological and psychosocial factors of patients with Marfan syndrome.

In Hungary, there are approximately 2500 patients whose treatment and environment are likely to be different from those in the above mentioned studies. Because life-saving aortic surgery itself bears great physical and mental shock and trauma for the patients, we hypothesized that the level of anxiety and depressive mood is higher in Marfan patients than in the normal patient population. Furthermore we hypothesized that patients receiving preventive surgery are more satisfied with their lives due to their beliefs that their chance for aortic dissection or rupture is mediated and their chance for survival is therefore greater. Thus the aim of the present study was to investigate these issues in a population of Hungarian Marfan patients using tests similar to those carried out by Van Tongerloo and De Paepe [9] regarding differences in the levels of anxiety, depression and life satisfaction among Marfan patients with and without cardiac surgeries and compared their results to those from normal patient population [10].

Due to the many combinations of the applied psychological tests, sample groups and the executed statistical analyzes, only the significant data are expounded below.

Using an independent samples t test, a significant difference was found on scores of trait anxiety between the Marfan population and the normal patient population (t(47) = 2.82, p < .01, Cohen’s d = .45). Average rates of high sample number tests of the Beck’s Depression Questionnaire [15] and STAI test [10], which were treated as the mean based on the mentioned source studies, were compared to the scores of Marfan syndrome patients with different surgical indications. The STAI trait anxiety scores of Marfan patients with life-saving surgery were significantly higher (p < 0.01) (Fig. 1). The average mean of Marfan syndrome patients was 48.56 (standard deviation: 5.8); STAI population mean score: 43.72, (standard deviation: 8.53; Sipos et al., 1978). There was no difference detected between Marfan and control for the BDI (p > 0.1).

A further question raised in the research was whether any difference may exist between the patient groups on the scales used. A multivariate analysis of variance (MANOVA) was applied on scale and subscale scores as dependent variables, and with Patient Group as a between-subject factor (three levels: No surgery, Prophylactic and Acute aortic surgery). A significant, medium size effect of patient groups on the Joy in Living scale (F(2,39) = 3.51, p = 0.040, η² = 0.15) was found. Pairwise comparisons revealed that patients with life-saving surgery (factor level Acute, M_Acute = 17.22, SD_Acute = 3.59) scored significantly higher on the scale than patients with no surgery (M_Nosurg = 14.00, SD_Nosurg = 3.44). There was no other effect of Patient Group in the MANOVA (all other Fs < 1.42).

Nevertheless, in other aspects of our study, significant statistical differences between the groups were not indeed expected, due to the small number of the patients involved in the recent study and many factors, which influence the applied tests (e.g. time of the diagnosis, how the patient is aware of the health condition, which other illnesses the patients have, etc.).

For most people, life-saving aortic surgery is a traumatic event, whereby they could experience the vulnerability of their lives, when they have to live in a constant, life-threatening and hardly definable distress. It can be a significant factor contributing to a permanent anxiety state, which is normally not present in healthy individuals without Marfan syndrome.

Based on the statistical analysis it can be concluded that patients suffering from Marfan syndrome and required life-saving aortic surgery due to aortic dissection experienced a greater anxiety in everyday life. This effect was unlikely to be a consequence of stress associated with cardiac surgery, as there was no significant difference between patients with prophylactic aortic surgery relative to the normal patient population.

Fusar-Poli and colleagues [18] examined 36 Marfan syndrome patients and found that the disease had a negative effect on the quality of life, was associated with increased psychological stress, and increased patient risk for the occurrence of certain psychiatric diseases. Hofman and colleagues [19] investigated nervous system and cognitive development of 30 children with Marfan syndrome. Based on their results, 50% of the children showed one or more neuropsychological deficits and symptoms similar to depression, which could be related to the serious motoric incoordination associated with Marfan syndrome. Baeza-Velasco and colleagues [20] showed that certain diseases of connective tissue (e.g. Marfan and Ehlers-Danlos syndrome) may be associated with various psychiatric symptoms, such as those of anxiety and depression.

Connective tissue disorders are a source of frustration for patients. Marfan syndrome may contribute to a sense of loss of personal efficacy due to physical disability and the need for cardiovascular intervention [21]. Furthermore, this syndrome has an autosomal dominant heritability, which results in a 50% chance of transmitting the mutant FBN1 gene to offspring; this knowledge may further augment persistent anxiety [22] about pregnancy for both patient’s own health and health of their children [23]. After diagnosis, having a lifelong, potentially disabling disease with the potential for multiple organ system involvement may intensify challenges in daily life, contributing to decreased quality of life and greater psychological distress [23]. Velvin and colleagues [23] noted that further research is required in order to better understand the potential importance of the psychosocial aspects of Marfan syndrome, as cardiac surgical intervention affects the whole life of the patient and might influence the psychological well-being of these patients as has been described here. It is necessary to inform the MFS patients about their condition after clinical diagnosis, and including consultation with a psychologist might help in processing this information in a healthier fashion. Finally, this additional support could foster better compliance and better treatment outcomes.

Our study highlights the presence of high anxiety in Marfan syndrome patients who have undergone life-saving aortic surgery, which is important for healthcare experts to note. Also deserving further consideration, in line with the findings of the research literature is that continuous anxiety has many negative effects on mental and physical health of patients [24, 25].

It would be reasonable to create a comprehensive psychological healthcare program to help Marfan patients to cope with anxiety. Since life-saving cardiac surgeries themselves are serious stress factors it is important to involve psychiatric and mental-health professionals at those institutions which perform cardiac surgery on Marfan patients [26]. Thus, both cardiovascular and psychological controls are significant in order to purposefully and effectively improve the quality of life of Marfan syndrome patients (Fig. 2). Further investigations are necessary to clearly understand the correlations revealed in this research.