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26.10.2015 | Original Article

The effects of diet- and RYGB-induced weight loss on insulin sensitivity in obese patients with and without type 2 diabetes

verfasst von: Merethe Hansen, Michael Taulo Lund, Anne Line Kjærholm Jørgensen, Marie Kroman Palsøe, Gerrit van Hall, Jørn Wulff Helge, Flemming Dela

Erschienen in: Acta Diabetologica | Ausgabe 3/2016

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Abstract

Aims

The impact of diet-induced weight loss and weight loss due to RYGB in patients with (T2DM, N = 16) and without (OB, N = 27) type 2 diabetes was studied.

Methods

At inclusion (A), after diet-induced weight loss (B), 4 months post-surgery (C) and 18 months post-surgery (D) body composition, hepatic glucose production (HGP), insulin-mediated glucose uptake (GIR), respiratory exchange ratio, hepatic insulin sensitivity and clearance were determined. GLUT4, intramuscular triglycerides (IMTG) and glycogen content were measured in skeletal muscle.

Results

Weight loss was 35–40 kg, and approximately one-third of the total improvement in GIR in T2DM was observed after the diet-induced weight loss of only ~6 kg (B). Insulin clearance, visceral fat and fasting plasma insulin also improved significantly after the diet (P < 0.05). Throughout the study, HGP, GLUT4 and glycogen content did not change significantly, but IMTG decreased significantly consistent with significant increases in GIR. Metabolic flexibility and hepatic insulin sensitivity improved after RYGB.

Conclusions

Metabolic improvements of RYGB are present already after the diet-induced weight loss prior to surgery. GLUT4 content in skeletal muscle cannot and IMTG content can only partly explain increases in GIR after RYGB.

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Titel: The effects of diet- and RYGB-induced weight loss on insulin sensitivity in obese patients with and without type 2 diabetes
verfasst von: Merethe Hansen
Michael Taulo Lund
Anne Line Kjærholm Jørgensen
Marie Kroman Palsøe
Gerrit van Hall
Jørn Wulff Helge
Flemming Dela
Publikationsdatum: 26.10.2015
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 3/2016
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-015-0812-2

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The effects of diet- and RYGB-induced weight loss on insulin sensitivity in obese patients with and without type 2 diabetes

Abstract

Aims

Methods

Results

Conclusions

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Parodontalbehandlung verbessert Prognose bei Katheterablation

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Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Aims

Methods

Results

Conclusions

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