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Erschienen in: Pediatric Cardiology 6/2015

01.08.2015 | Original Article

The Effects of Hemodynamic Alterations on Lung Volumes in Fetuses with Tetralogy of Fallot: An MRI Study

verfasst von: Vanessa Berger-Kulemann, Rudolf Berger, Elisabeth Mlczoch, Daniel Sternal, Mariella Mailath-Pokorny, Nilouparak Hachemian, Daniela Prayer, Michael Weber, Ulrike Salzer-Muhar

Erschienen in: Pediatric Cardiology | Ausgabe 6/2015

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Abstract

This study assessed whether the presence of tetralogy of Fallot (TOF) affects fetal lung development and whether these fetuses are at risk of pulmonary hypoplasia (PH). Furthermore, we investigated whether the degree of the concomitant pulmonary valve (PV) stenosis or a stenosis in the branch pulmonary arteries correlates with the fetal lung volume. Lung volumetry was performed in 16 fetuses with TOF who underwent MRI between gestational weeks 21 and 35 and in 22 controls. Fetal biometric data and the diameters of the PVs were evaluated by ultrasound. PV and branch pulmonary artery diameters were standardized (z-scores), and fetal lung volume/fetal body weight (FLV/FBW) ratios (ml/g) were calculated. The mean FLV/FBW ratio (0.031 ± 0.009 ml/g) in the TOF group was statistically significantly lower than in the control group (0.041 ± 0.009 ml/g; P = 0.003). None of the fetuses with TOF met the criterion for PH. FLV did not correlate with the degree of PV stenosis, but rather with the presence of a significant stenosis in at least one branch pulmonary artery. The presence of TOF moderately affects fetal lung growth, which is apparently not dependent on the degree of the PV stenosis. However, only an additional stenosis in at least one branch pulmonary artery was associated with a small FLV, but not with PH. Thus, reduced pulmonary blood flow may be offset by additional factors, such as the ability to establish a sufficient collateral system and to alter structural vascular size and, thus, pulmonary vascular resistance.
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Metadaten
Titel
The Effects of Hemodynamic Alterations on Lung Volumes in Fetuses with Tetralogy of Fallot: An MRI Study
verfasst von
Vanessa Berger-Kulemann
Rudolf Berger
Elisabeth Mlczoch
Daniel Sternal
Mariella Mailath-Pokorny
Nilouparak Hachemian
Daniela Prayer
Michael Weber
Ulrike Salzer-Muhar
Publikationsdatum
01.08.2015
Verlag
Springer US
Erschienen in
Pediatric Cardiology / Ausgabe 6/2015
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI
https://doi.org/10.1007/s00246-015-1159-8

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