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04.12.2018 | Urology - Original Paper

The effects of oxytocin on penile tissues in experimental priapism model in rats

verfasst von: Engin Kolukcu, Sahin Kilic, Bekir Suha Parlaktas, Fikret Erdemir, Velid Unsal, Dogan Atılgan, Nihat Uluocak

Erschienen in: International Urology and Nephrology | Ausgabe 2/2019

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Abstract

Purpose

This study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia–reperfusion injury developed after priapism.

Methods

Forty Wistar Albino strain male rats were divided into four groups. The control group (n = 10) was not intervened. In Group 2, a rat model of priapism was constructed and maintained for 1 h. In Group 3, reperfusion was ensured for 30 min following priapism. Rats in Group 4 rats were given oxytocin 30 min before the induction of reperfusion following priapism. All rats were penectomized, and adequate amounts of blood sample were drawn. Inflammation, vasocongestion, desquamation, and edema in penile tissue were scored between 0 and 3 points (0: normal, 1: mild, 2: moderate, 3: severe) to evaluate the severity of tissue damage. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the levels of malondialdehyde (MDA), and nitric oxide (NO) in blood samples were determined spectrophotometrically.

Results

In histopathological examination, statistically significant positive changes were detected in vasocongestion, inflammation, desquamation, and edema scores in Group 4 than in Group 2 and Group 3 (p < 0.001). Biochemical test results revealed that NO levels were significantly lower in Group 4 than in Group 3 (p < 0.001). Serum GSH-Px activities in Group 4 significantly increased when compared with the other groups 2 and 3 (p = 0.002, p = 0.001, respectively). There was no statistical difference among the groups regarding SOD activities and MDA levels (p > 0.05).

Conclusions

Oxytocin protected against priapism-induced ischemia–reperfusion injury developed in cavernosal tissue as observed based on histopathological and biochemical evidence. Although this is an experimental study, oxytocin can be thought as an alternative drug in the treatment of priapism.

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Titel: The effects of oxytocin on penile tissues in experimental priapism model in rats
verfasst von: Engin Kolukcu
Sahin Kilic
Bekir Suha Parlaktas
Fikret Erdemir
Velid Unsal
Dogan Atılgan
Nihat Uluocak
Publikationsdatum: 04.12.2018
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 2/2019
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-018-2046-z

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The effects of oxytocin on penile tissues in experimental priapism model in rats

Abstract

Purpose

Methods

Results

Conclusions

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