The Effects of Resveratrol Supplementation on Endothelial Function and Blood Pressures Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- 01.08.2019
- Review article
- Verfasst von
- Maryam Akbari
- Omid Reza Tamtaji
- Kamran B. Lankarani
- Reza Tabrizi
- Ehsan Dadgostar
- Fariba Kolahdooz
- Mehri Jamilian
- Hamed Mirzaei
- Zatollah Asemi
- Erschienen in
- High Blood Pressure & Cardiovascular Prevention | Ausgabe 4/2019
Abstract
Introduction
There are current trials investigating the effect of resveratrol supplementation on endothelial function and blood pressures among patients with metabolic syndrome (MetS); however, the findings are controversial.
Aim
This systematic review and meta-analysis of randomized controlled trials (RCTs) were carried out to summarize the effects of resveratrol supplementation on endothelial activation and blood pressures among patients with MetS and related disorders.
Methods
We searched systematically online databases including: PubMed-Medline, Embase, ISI Web of Science and Cochrane Central Register of Controlled Trials until October, 2018. Two independent authors extracted data and assessed the quality of included articles. Data were pooled using the fixed- or random-effects model and considered as standardized mean difference (SMD) with 95% confidence intervals (95% CI).
Results
Out of 831 electronic citations, 28 RCTs (with 33 findings reported) were included in the meta-analyses. The findings showed that resveratrol intervention significantly increased flow-mediated dilatation (FMD) levels (SMD 1.77; 95% CI 0.25, 3.29; P = 0.02; I2: 96.5). However, resveratrol supplements did not affect systolic blood pressure (SBP) (SMD − 0.27; 95% CI − 0.57, 0.03; P = 0.07; I2: 88.9) and diastolic blood pressure (DBP) (SMD − 0.21; 95% CI − 0.52, 0.11; P = 0.19; I2: 89.8).
Conclusions
Resveratrol supplementation significantly increased FMD among patients with MetS and related disorders, but did not affect SBP and DBP. Additional prospective studies are needed to investigate the effect of resveratrol supplementation on endothelial function and blood pressures, using higher-dose of resveratrol with longer durations.
Anzeige
- Titel
- The Effects of Resveratrol Supplementation on Endothelial Function and Blood Pressures Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Verfasst von
-
Maryam Akbari
Omid Reza Tamtaji
Kamran B. Lankarani
Reza Tabrizi
Ehsan Dadgostar
Fariba Kolahdooz
Mehri Jamilian
Hamed Mirzaei
Zatollah Asemi
- Publikationsdatum
- 01.08.2019
- Verlag
- Springer International Publishing
- Erschienen in
-
High Blood Pressure & Cardiovascular Prevention / Ausgabe 4/2019
Print ISSN: 1120-9879
Elektronische ISSN: 1179-1985 - DOI
- https://doi.org/10.1007/s40292-019-00324-6
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.