The online version of this article (doi:10.1186/1475-2875-11-403) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
AJT conceived the analyses. QQ and AJT developed the study design and QQ conducted the analyses. CAG, CMM and IRF gathered and processed the malaria prevalence data. PWG, CAG and SIH undertook construction of the vivax limits and dominant vector species dataset. All authors contributed to the writing of the manuscript. All authors read and approved the final manuscript.
Many recent studies have examined the impact of urbanization on Plasmodium falciparum malaria endemicity and found a general trend of reduced transmission in urban areas. However, none has examined the effect of urbanization on Plasmodium vivax malaria, which is the most widely distributed malaria species and can also cause severe clinical syndromes in humans. In this study, a set of 10,003 community-based P. vivax parasite rate (Pv PR) surveys are used to explore the relationships between Pv PR in urban and rural settings.
The Pv PR surveys were overlaid onto a map of global urban extents to derive an urban/rural assignment. The differences in Pv PR values between urban and rural areas were then examined. Groups of Pv PR surveys inside individual city extents (urban) and surrounding areas (rural) were identified to examine the local variations in Pv PR values. Finally, the relationships of Pv PR between urban and rural areas within the ranges of 41 dominant Anopheles vectors were examined.
Significantly higher Pv PR values in rural areas were found globally. The relationship was consistent at continental scales when focusing on Africa and Asia only, but in the Americas, significantly lower values of Pv PR in rural areas were found, though the numbers of surveys were small. Moreover, except for the countries in the Americas, the same trends were found at national scales in African and Asian countries, with significantly lower values of Pv PR in urban areas. However, the patterns at city scales among 20 specific cities where sufficient data were available were less clear, with seven cities having significantly lower Pv PR values in urban areas and two cities showing significantly lower Pv PR in rural areas. The urban–rural Pv PR differences within the ranges of the dominant Anopheles vectors were generally, in agreement with the regional patterns found.
Except for the Americas, the patterns of significantly lower P. vivax transmission in urban areas have been found globally, regionally, nationally and by dominant vector species here, following trends observed previously for P. falciparum. To further understand these patterns, more epidemiological, entomological and parasitological analyses of the disease at smaller spatial scales are needed.
Additional file 1: Results of Wilcoxon Signed Rank tests on Pv PR values between GRUMP-UE defined urban (U) and rural(R) survey pairs for the dominant Anopheles vectors of human malaria. (DOCX 22 KB)12936_2012_2558_MOESM1_ESM.docx
Additional file 2: Results of Wilcoxon Signed Rank tests on Pv PR values between MODIS defined urban (U) and rural(R) survey pairs for continents, countries and the World. (DOCX 15 KB)12936_2012_2558_MOESM2_ESM.docx
Authors’ original file for figure 112936_2012_2558_MOESM3_ESM.pdf
Authors’ original file for figure 212936_2012_2558_MOESM4_ESM.pdf
Authors’ original file for figure 312936_2012_2558_MOESM5_ESM.pdf
United Nations: World urbanization prospect, the 2011 revision. 2011, New York: United Nations
Moore M, Gould P, Keary BS: Global urbanization and impact on health. Int J Hyg Envir Heal. 2003, 206: 269-278. 10.1078/1438-4639-00223. CrossRef
Robert V, Macintyre K, Keating J, Trape J-F, Duchemin J-B, Warren M, Beier JC: Malaria transmission in urban sub-Saharan Africa. AmJTrop Med Hyg. 2003, 68: 169-176.
Hay SI, Guerra CA, Tatem AJ, Atkinson PM, Snow RW: Urbanization, malaria transmission and disease burden in Africa. Nat Rev Micro. 2005, 3: 81-90. 10.1038/nrmicro1069. CrossRef
Keiser J, Utzinger J, De Castro MC, Smith TA, Tanner M, Singer BH: Urbanization in sub-Saharan Africa and implication for malaria control. Am J Trop Med Hyg. 2004, 71: 118-127. PubMed
Mendis K, Sina B, Marchesini P, Carter R: The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg. 2001, 64: 97-106. PubMed
Guerra CA, Howes RE, Patil AP, Gething PW, Van Boeckel TP, Temperley WH, Kabaria CW, Tatem AJ, Manh BH, Elyazar IRF, Baird JK, Snow RW, Hay SI: The international limits and population at risk of plasmodium vivax transmission in 2009. PLoS Negl Trop Dis. 2010, 4: e774-10.1371/journal.pntd.0000774. PubMedCentralCrossRefPubMed
Sinka M, Bangs M, Manguin S, Coetzee M, Mbogo C, Hemingway J, Patil A, Temperley W, Gething P, Kabaria C, Okara R, Van Boeckel T, Godfray HC, Harbach R, Hay S: The dominant Anopheles vectors of human malaria in Africa, Europe and the Middle East: occurrence data, distribution maps and bionomic precis. Parasit Vectors. 2010, 3: 117-10.1186/1756-3305-3-117. PubMedCentralCrossRefPubMed
Sinka M, Bangs M, Manguin S, Chareonviriyaphap T, Patil A, Temperley W, Gething P, Elyazar I, Kabaria C, Harbach R, Hay S: The dominant Anopheles vectors of human malaria in the Asia-Pacific region: occurrence data, distribution maps and bionomic precis. Parasit Vectors. 2011, 4: 89-10.1186/1756-3305-4-89. PubMedCentralCrossRefPubMed
Sinka M, Rubio-Palis Y, Manguin S, Patil A, Temperley W, Gething P, Van Boeckel T, Kabaria C, Harbach R, Hay S: The dominant Anopheles vectors of human malaria in the Americas: occurrence data, distribution maps and bionomic precis. Parasit Vectors. 2010, 3: 72-10.1186/1756-3305-3-72. PubMedCentralCrossRefPubMed
Sharma VP: Fighting malaria in India. Current sci (Bangalore). 1998, 75: 1127-
Surendran SN, Ramasamyb R: Some characteristics of the larval breeding sites of Anopheles culicifacies species B and E in Sri Lanka. J Vector Dis. 2005, 42: 39-44.
Batra CP, Mittal PK, Adak T, Subbarao SK: Efficacy of Agnique MMF monomolecular surface film against Anopheles stephensi breeding in urban habitats in India. J Am Mosquito Contr. 2006, 22: 426-432. 10.2987/8756-971X(2006)22[426:EOAMMS]2.0.CO;2. CrossRef
Biswas D, Dutta R, Ghosh S, Chatterjee K, Hati A: Breeding habits of Anopheles stephensi Liston in an area of Calcutta. Indian J Malariol. 1992, 29: 195-198. PubMed
Malaria Atlas Project: [ http://www.map.ox.ac.uk]
Danko DM: The digital chart of the world project. Photogramm Eng Rem S. 1992, 58: 1125-1128.
Hansen M, DeFries R, Townshend JRG, Sohlberg R: 1 km land cover classification derived from AVHRR. College Park. 1998, Maryland: The Global Land Cover Facility
Elvidge CD, Baugh KE, Kihn EA, Kroehl HW, Davis ER: Mapping city lights with nighttime data from the DMSP operational linescan system. Photogramm Eng Rem S. 1997, 63: 727-734.
Schneider A, Friedl MA, Potere D: A new map of global urban extent from MODIS data. Environ Res Lett. 2009, 4: 4- CrossRef
Schneider A, Friedl MA, Potere D: Monitoring urban areas globally using MODIS 500 m data: New methods and datasets based on urban ecoregions. Remote Sens Environ. 2010, 114: 1733-1746. 10.1016/j.rse.2010.03.003. CrossRef
Center for Internation Earth Science Information Network(CIESIN), Columbia University: Global rural–urban mapping project (GRUMP): urban extents. International food policy research institute (IFPRI), the world band, centro international de agricultura tropical (CIAT). 2004, Palisades, New York: CIESIN, Columbia University
Hay SI, Sinka ME, Okara RM, Kabaria CW, Mbithi PM, Tago CC, Benz D, Gething PW, Howes RE, Patil AP, Temperley WH, Bangs MJ, Chareonviriyaphap T, Elyazar IRF, Harbach RE, Hemingway J, Manguin S, Mbogo CM, Rubio-Palis Y, Godfray HCJ: Developing global maps of the dominant Anopheles vectors of human malaria. PLoS Med. 2010, 7: e1000209-10.1371/journal.pmed.1000209. PubMedCentralCrossRefPubMed
Gupta D, Bhatt R, Sharma R, Gautam A, Rajnikant AS: Intradomestic mosquito breeding sources and their management. Indian J Malariol. 1992, 29: 41-46. PubMed
Wilcoxon F: Individual comparisons by ranking methods. Biometrics. 1945, 1: 761-764.
Goncalves MJF, Alecrim WD: Non-planned urbanization as a contributing factor for malaria incidence in Manaus-Amazonas, Brazil. Rev Salud Pública. 2004, 6: 156-166. CrossRef
Sutton PC: A scale-adjusted measure of “Urban sprawl” using nighttime satellite imagery. Remote Sens Environ. 2003, 86: 353-369. 10.1016/S0034-4257(03)00078-6. CrossRef
Weiss RA, McMichael AJ: Social and environmental risk factors in the emergence of infectious diseases. Nat Med. 2004, 10: 70-76. 10.1038/nm1150. CrossRef
Patz JA, Daszak P, Tabor GM, Aguirre AA, Pearl M, Epstein J, Wolfe ND, Kilpatrick AM, Foufopoulos J, Molyneux D, Bradley DJ: Unhealthy landscapes: policy recommendations on land use change and infectious disease emergence. Environ Health Perspect. 2004, 112: 1092-1098. 10.1289/ehp.6877. PubMedCentralCrossRefPubMed
Norris DE: Mosquito-borne diseases as a consequence of land use change. Ecohealth. 2004, 1: 19-24. 10.1007/s10393-004-0008-7. CrossRef
Chinery WA: Effects of ecological changes on the malaria vectors Anopheles funestus and the Anopheles gambiae complex of mosquitoes in Accra. Ghana. J Trop Med Hyg. 1984, 87: 191-206.
Awolola TS, Oduola AO, Obansa JB, Chukwurar NJ, Unyimadu JP: Anopheles gambiae s.s. breading in polluted water bodies in urban Lagos, southwestern Nigeria. J Vector Dis. 2007, 44: 241-244.
Matthys B, Vounatsou P, Raso G, Tschannen AB, Becket EG, Gosoniu L, Cisse G, Tanner M, N’goran EK, Utzinger J: Urban farming and malaria risk factors in a medium-sized town in Côte d’Ivoire. Am J Trop Med Hyg. 2006, 75: 1223-1231. PubMed
- The effects of urbanization on global Plasmodium vivax malaria transmission
Carlos A Guerra
Catherine L Moyes
Iqbal AR F Elyazar
Peter W Gething
Simon I Hay
Andrew J Tatem
- BioMed Central
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