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Documenta Ophthalmologica
Erschienen in: Documenta Ophthalmologica 1/2010

01.08.2010 | REVIEW ARTICLE

The electroretinogram: a useful tool for evaluating age-related macular disease?

verfasst von: Emma J. Berrow, Hannah E. Bartlett, Frank Eperjesi, Jonathan M. Gibson

Erschienen in: Documenta Ophthalmologica | Ausgabe 1/2010

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Abstract

With an ageing population, the number of age-related macular disease (ARMD) cases will inevitably rise. This gives greater impetus for the need to identify the disease earlier and assess treatments to slow disease progression. Differing electroretinogram (ERG) modalities have been reviewed in relation to the objective assessment of retinal function in ARMD and for monitoring the effectiveness of clinical interventions. Conflicting results have been found with regard to the efficacy of ERG findings in the investigation of ARMD in previous years. The newer multifocal ERG paradigm provides spatial topographical information about retinal function in ARMD. It has shown promising results in monitoring effectiveness of clinical interventions and studies are continuing in this area. Better knowledge of retinal function in ARMD may lead to enhanced treatments at each phase of the disease.
Literatur
1.
Klein R, Klein BEK, Tomany SC, Meuer SM, Huang GH (2002) Ten-year incidence and progression of age-related maculopathy. Ophthalmology 109:1767–1779CrossRefPubMed
2.
Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, Davis MD, de Jong PTVM, Klaver CCW, Klein BEK, Klein R, Mitchell P, Sarks JP, Sarks SH, Soubrane G, Taylor HR, Vingerling JR (1995) An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol 39:367–374CrossRefPubMed
3.
Kaur C, Foulds WS, Ling EA (2008) Blood-retinal barrier in hypoxic ischaemic conditions: basic concepts, clinical features and management. Prog Retin Eye Res 27:622–647CrossRefPubMed
4.
Moore DJ (1995) Age-related variation in the hydraulic conductivity of bruch’s membrane. Invest Ophthalmol Vis Sci 36:1290–1297PubMed
5.
Zarbin M (2004) Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol 122:598–614CrossRefPubMed
6.
Feigl B, Lovie-Kitchin J, Brown B (2005) Objective functional assessment of age-related maculopathy: a special application for the multifocal electroretinogram. Clin Exp Optom 88:304–312CrossRefPubMed
7.
Heckenlively JR, Arden GB (2006) Principles and practical of clinical electrophysiology of vision, 2nd edn. MIT press, Cambridge, MA
8.
Grunwald JE, Metelitsina TI, DuPont JC, Ying GS, Maguire MG (2005) Reduced foveolar choroidal blood flow in eyes with increasing AMD severity. Invest Ophthalmol Vis Sci 46:1033–1038CrossRefPubMed
9.
Jackson GR, McGwin JG, Phillips JM, Klein R, Owsley C (2006) Impact of aging and age-related maculopathy on inactivation of the a-wave of the rod-mediated electroretinogram. Vision Res 46:1422–1431CrossRefPubMed
10.
Walter P, Widder RA, Luke C, Konigsfeld P, Brunner R (1999) Electrophysiological abnormalities in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 237:962–968CrossRefPubMed
11.
Marcus M, Merin S, Wolf M, Feinsod M (1983) Electrophysiologic tests in assessment of senile macular degeneration. Ann Ophthalmol 15:235–238PubMed
12.
Holopigian K, Seiple W, Greenstein V, Kim D, Carr RE (1997) Relative effects of aging and age-related macular degeneration on peripheral visual function. Optom Vis Sci 74:152–159CrossRefPubMed
13.
Birch DG, Anderson JL (1992) Standardized full-field electroretinography—normal values and their variation with age. Arch Ophthalmol 110:1571–1576PubMed
14.
Scullica L, Falsini B (2001) Diagnosis and classification of macular degenerations: an approach based on retinal function testing. Doc Ophthalmol 102:237–250CrossRefPubMed
15.
Hogg RE, Chakravarthy U (2006) Visual function and dysfunction in early and late age-related maculopathy. Prog Retin Eye Res 25:249–276CrossRefPubMed
16.
Bach MHM (2006) The origin of the pattern electroretinogram. In: Heckenlively JR, Arden GB (eds) Principles and practical of clinical electrophysiology of vision, MIT Press, Cambridge, MA, pp 185–196
17.
Holder GE (2001) Pattern electroretinography (PERG) and an integrated approach to visual pathway diagnosis. Prog Retin Eye Res 20:531–561CrossRefPubMed
18.
Trick GL (2003) Beyond visual acuity: new and complementary tests of visual function. Neurol Clin of N Am 21:363–386
19.
Mackay AM, Brown MC, Hagan RP, Fisher AC, Grierson I, Harding SP (2007) Deficits in the electroretinogram in neovascular age-related macular degeneration and changes during photodynamic therapy. Doc Ophthalmol 115:69–76CrossRefPubMed
20.
Neveu MM, Tufail A, Dowler JG, Holder GE (2006) A comparison of pattern and multifocal electroretinography in the evaluation of age-related macular degeneration and its treatment with photodynamic therapy. Doc Ophthalmol 113:71–81CrossRefPubMed
21.
Oner A, Karakucuk S, Mirza E, Erkilic K (2005) The changes of pattern electroretinography at the early stage of photodynamic therapy. Doc Ophthalmol 111:107–112CrossRefPubMed
22.
Arden GB, Bankes JL (1966) Foveal electroretinogram as a clinical test. Br J Ophthalmol 50:740CrossRefPubMed
23.
Birch DG, Fish GE (1988) Focal cone electroretinograms—aging and macular disease. Doc Ophthalmol 69:211–220CrossRefPubMed
24.
Bankes JL (1967) The foveal electroretinogram. Trans Ophthalmol Soc U K 87:249–262PubMed
25.
Seiple WH, Siegel IM, Carr RE, Mayron C (1986) Evaluating macular function using the focal erg. Invest Ophthalmol Vis Sci 27:1123–1130PubMed
26.
Sandberg MA, Miller S, Gaudio AR (1993) Foveal cone ergs in fellow eyes of patients with unilateral neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 34:3477–3480PubMed
27.
Remulla JFC, Gaudio AR, Miller S, Sandberg MA (1995) Foveal electroretinograms and choroidal perfusion characteristics in fellow eyes of patients with unilateral neovascular age-related macular degeneration. Br J of Ophthalmol 79:558–561CrossRef
28.
Falsini B, Serrao S, Fadda A, Iarossi G, Porrello G, Cocco F, Merendino E (1999) Focal electroretinograms and fundus appearance in nonexudative age-related macular degeneration—quantitative relationship between retinal morphology and function. Graefes Arch Clin Exp Ophthalmol 237:193–200CrossRefPubMed
29.
Falsini B, Piccardi M, Iarossi G, Fadda A, Merendino E, Valentini P (2003) Influence of short-term antioxidant supplementation on macular function in age-related maculopathy. A pilot study including electrophysiologic assessment. Ophthalmology 110:51–60CrossRefPubMed
30.
Binns AM, Margrain TH (2007) Evaluating retinal function in age-related maculopathy with the erg photostress test. Invest Ophthalmol Vis Sci 48:2806–2813CrossRefPubMed
31.
Sutter EE, Tran D (1992) The field topography of erg components in man. 1. The photopic luminance response. Vision Res 32:433–446CrossRefPubMed
32.
Sutter EE (1991) The fast m-transform—a fast computation of cross-correlations with binary m-sequences. SIAM J Comput 20:686–694CrossRef
33.
Palmowski AM, Sutter EE, Bearse MA, Fung W (1999) Multifocal electroretinography (mf-erg) in age-related macular degeneration. Ophthalmologe 96:166–173CrossRefPubMed
34.
Lai TYY, Chan WM, Lai RYK, Ngai JWS, Li HT, Lam DSC (2007) The clinical applications of multifocal electroretinography: a systematic review. Surv Ophthalmol 52:61–96CrossRefPubMed
35.
Hood DC (2000) Assessing retinal function with the multifocal technique. Prog Retin Eye Res 19:607–646CrossRefPubMed
36.
Sutter EE (2001) Imaging visual function with the multifocal m-sequence technique. Vision Res 41:1241–1255CrossRefPubMed
37.
Sutter E (2000) The interpretation of multifocal binary kernels. Doc Ophthalmol 100:49–75CrossRef
38.
Gerth C (2009) The role of the erg in the diagnosis and treatment of age-related macular degeneration. Doc Ophthalmol 118:63–68CrossRefPubMed
39.
Parisi VM, Perillo LM, Tedeschi MM, Scassa CM, Gallinaro GB, Capaldo NB, Varano MM (2007) Macular function in eyes with early age-related macular degeneration with or without contralateral late age-related macular degeneration. Retin 27:879–890CrossRef
40.
Gerth C, Hauser D, Delahunt PB, Morse LS, Werner JS (2003) Assessment of multifocal electroretinogram abnormalities and their relation to morphologic characteristics in patients with large drusen. Arch Ophthalmol 121:1404–1414CrossRefPubMed
41.
Feigl B (2007) Age-related maculopathy in the light of ischaemia. Clin Exp Optom 90:263–271CrossRefPubMed
42.
Lai TYY, Chan W-M, Lam DSC (2004) Transient reduction in retinal function revealed by multifocal electroretinogram after photodynamic therapy. Am J Ophthalmol 137:826–833CrossRefPubMed
43.
Kretschmann U, Seeliger M, Ruether K, Usui T, Zrenner E (1998) Spatial cone activity distribution in diseases of the posterior pole determined by multifocal electroretinography. Vision Res 38:3817–3828CrossRefPubMed
44.
Huang S, Wu D, Jiang F, Ma J, Wu L, Liang J, Luo G (2000) The multifocal electroretinogram in age-related maculopathies. Doc Ophthalmol 101:115–124CrossRefPubMed
45.
Heinemann-Vernaleken B, Palmowski AM, Allgayer R, Ruprecht KW (2001) Comparison of different high resolution multifocal electroretinogram recordings in patients with age-related maculopathy. Graefes Arch Clin Exp Ophthalmol 239:556–561CrossRefPubMed
46.
Li J, Tso MOM, Lam TT (2001) Reduced amplitude and delayed latency in foveal response of multifocal electroretinogram in early age related macular degeneration. Br J Ophthalmol 85:287–290CrossRefPubMed
47.
Chen CZ, Wu LZ, Wu DZ, Huang SZ, Wen F, Luo GW, Long SX (2004) The local cone and rod system function in early age-related macular degeneration. Doc Ophthalmol 109:1–8PubMed
48.
Feigl B, Brown B, Lovie-Kitchin J, Swann P (2006) Postreceptoral adaptation abnormalities in early age-related maculopathy. Vis Neurosci 23:863–870CrossRefPubMed
49.
Feigl B, Brown B, Lovie-Kitchin J, Swann P (2004) Cone-mediated multifocal electroretinogram in early age-related maculopathy and its relationships with subjective macular function tests. Curr Eye Res 29:327–336CrossRefPubMed
50.
Feigl B, Brown B, Lovie-Kitchin J, Swann P (2006) The rod-mediated multifocal electroretinogram in aging and in early age-related maculopathy. Curr Eye Res 31:635–644CrossRefPubMed
51.
Feigl B, Brown B, Lovie-Kitchin J, Swann P (2005) Adaptation responses in early age-related maculopathy. Invest Ophthalmol Vis Sci 46:4722–4727CrossRefPubMed
52.
Feigl B, Brown B, Love-Kitchin J, Swann P (2005) Cone- and rod-mediated multifocal electroretinogram in early age-related maculopathy. Eye 19:431–441CrossRefPubMed
53.
Feigl B, Brown B, Lovie-Kitchin J, Swann P (2005) Monitoring retinal function in early age-related maculopathy: visual performance after 1 year. Eye 19:1169–1177CrossRefPubMed
54.
Parisi V, Tedeschi M, Gallinaro G, Varano M, Saviano S, Piermarocchi S (2008) Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after 1 year. Ophthalmology 115:324–333 e322
55.
Karanjia R, Eng KT, Gale J, Sharma S, ten Hove MW (2008) Electrophysiological effects of intravitreal avastin (bevacizumab) in the treatment of exudative age-related macular degeneration. Br J Ophthalmol 92:1248–1252CrossRefPubMed
56.
Jiang LB, Jin CJ, Wen F, Huang SZ, Wu DZ, Wu LZ (2003) The changes of multifocal electroretinography in the early stage of photodynamic therapy for choroidal neovascularization. Doc Ophthalmol 107:165–170CrossRefPubMed
57.
Palmowski AM, Allgayer R, Heinemann-Vernaleken B, Ruprecht KW (2002) Influence of photodynamic therapy in choroidal neovascularization on focal retinal function assessed with the multifocal electroretinogram and perimetry. Ophthalmology 109:1788–1792CrossRefPubMed
58.
Mackay AM, Brown MC, Grierson I, Harding SP (2008) Multifocal electroretinography as a predictor of maintenance of vision after photodynamic therapy for neovascular age-related macular degeneration. Doc Ophthalmol 116:13–18CrossRefPubMed
59.
Feigl B (2009) Age-related maculopathy—linking aetiology and pathophysiological changes to the ischaemia hypothesis. Prog Retin Eye Res 28:63–86CrossRefPubMed
60.
Nabeshima T, Tazawa Y, Mita M, Sano M (2002) Effects of aging on the first and second-order kernels of multifocal electroretinogram. Jpn J Ophthalmol 46:261–269CrossRefPubMed
61.
Mohidin N, Yap MKH, Jacobs RJ (1999) Influence of age on the multifocal electroretinography. Ophthalmic Physiol Optics 19:481–488CrossRef
62.
Seiple W, Vajaranant TS, Szlyk JP, Clemens C, Holopigian K, Paliga J, Badawi D, Carr RE (2003) Multifocal electroretinography as a function of age: the importance of normative values for older adults. Invest Ophthalmol Vis Sci 44:1783–1792CrossRefPubMed
63.
Hood DC, Bach M, Brigell M, Keating D, Kondo M, Lyons JS, Palmowski-Wolfe AM (2008) ISCEV guidelines for clinical multifocal electroretinography (2007 edition). Doc Ophthalmol 116:1–11CrossRefPubMed
64.
Hood DC, Wladis EJ, Shady S, Holopigian K, Li J, Seiple W (1998) Multifocal rod electroretinograms. Invest Ophthalmol Vis Sci 39:1152–1162PubMed
65.
Feigl B, Stewart IB, Brown B, Zele AJ (2008) Local neuroretinal function during acute hypoxia in healthy older people. Invest Ophthalmol Vis Sci 49:807–813CrossRefPubMed
66.
Feigl B, Stewart I, Brown B (2007) Experimental hypoxia in human eyes: implications for ischaemic disease. Clin Neurophysiol 118:887–895CrossRefPubMed
67.
Feigl B, Brown B, Lovie-Kitchin J, Swann P (2007) Functional loss in early age-related maculopathy: the ischaemia postreceptoral hypothesis. Eye 21:689–696CrossRefPubMed
68.
Gerth C, Delahunt PB, Alam S, Morse LS, Werner JS (2006) Cone-mediated multifocal electroretinogram in age-related macular degeneration—progression over a long-term follow-up. Arch Ophthalmol 124:345–352CrossRefPubMed
69.
Parisi V, Perillo L, Tedeschi M, Scassa C, Gallinaro G, Capaldo N, Varano M (2007) Macular function in eyes with early age-related macular degeneration with or without contralateral late age-related macular degeneration. Retin-J Retin Vitreous Dis 27:879–890
70.
Husain D, Kramer M, Kenny AG, Michaud N, Flotte TJ, Gragoudas ES, Miller JW (1999) Effects of photodynamic therapy using verteporfin on experimental choroidal neovascularization and normal retina and choroid up to 7 weeks after treatment. Invest Ophthalmol Vis Sci 40:2322–2331PubMed
71.
Rüther KB K, Schwartz R, Hassenstein A, Richard G (2003) Testing central retinal function with multifocal electroretinography before and after photodynamic therapy. Ophthalmologe 100:459–464
72.
Catala-Mora J, Castany-Aregall M, Berniell-Trota JA, Arias-Barquet L, Roca-Linares G, Jurgens-Mestre I (2005) Multifocal electroretinogram and age-related macular degeneration. Arch Soc Esp Oftalmol 80:395–404CrossRefPubMed
73.
Moschos MM, Panayotidis D, Theodossiadis G, Moschos M (2004) Assessment of macular function by multifocal electroretinogram in age-related macular degeneration before and after photodynamic therapy. J Fr Ophthamol 27:1001–1006CrossRef
74.
Feigl B, Brown B, Lovie-Kitchin J, Lee L (2005) Dynamics of retinal function after multiple photodynamic therapies in age-related macular degeneration: a report of cases. Doc Ophthalmol 111:135–148CrossRefPubMed
75.
Moschos MM, Brouzas D, Apostolopoulos M, Koutsandrea C, Loukianou E, Moschos M (2007) Intravitreal use of bevacizumab (avastin) for choroidal neovascularization due to ARMD: a preliminary multifocal-ERG and OCT study. Doc Ophthalmol 114:37–44CrossRefPubMed
76.
Maturi RK, Bleau LA, Wilson DL (2006) Electrophysiologic findings after intravitreal bevacizumab (avastin) treatment. Retin-J Retin Vitreous Dis 26:270–274
77.
Feigl B, Greaves A, Brown B (2007) Functional outcomes after multiple treatments with ranibizumab in neovascular age-related macular degeneration beyond visual acuity. Clin Ophthalmol 1:167–175PubMed
78.
Parravano M, Oddone F, Tedeschi M, Lomoriello DS, Chiaravalloti A, Ripandelli G, Varano M (2009) Retinal functional changes measured by microperimetry in neovascular age-related macular degeneration patients treated with ranibizumab. Retin-J Retin Vitreous Dis 29:329–334
Metadaten
Titel
The electroretinogram: a useful tool for evaluating age-related macular disease?
verfasst von
Emma J. Berrow
Hannah E. Bartlett
Frank Eperjesi
Jonathan M. Gibson
Publikationsdatum
01.08.2010
Verlag
Springer-Verlag
Erschienen in
Documenta Ophthalmologica / Ausgabe 1/2010
Print ISSN: 0012-4486
Elektronische ISSN: 1573-2622
DOI
https://doi.org/10.1007/s10633-010-9226-1

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