The elusive function of AMH signaling in folliculogenesis
- 19.09.2025
- Commentary
- Verfasst von
- Michael W. Pankhurst
- Erschienen in
- Journal of Assisted Reproduction and Genetics | Ausgabe 10/2025
Auszug
Anti-Müllerian hormone (AMH, also previously known as Müllerian-inhibiting substance) is an ovarian regulator that can influence all stages of folliculogenesis. It is well established that AMH can inhibit primordial follicle activation [1, 2] but there is less consensus on how AMH affects the other stages of folliculogenesis. This controversy has been apparent since the very first in vitro experiments examining the effects of AMH on follicle growth. In 2001, Durlinger et al. observed that AMH could inhibit the growth-promoting effects of FSH on cultured mouse follicles [3]. In the same year, McGee et al. published an article showing that recombinant AMH actually stimulated rat follicle growth, an effect that was further improved by the addition of FSH [4]. …
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- Titel
- The elusive function of AMH signaling in folliculogenesis
- Verfasst von
-
Michael W. Pankhurst
- Publikationsdatum
- 19.09.2025
- Verlag
- Springer US
- Erschienen in
-
Journal of Assisted Reproduction and Genetics / Ausgabe 10/2025
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330 - DOI
- https://doi.org/10.1007/s10815-025-03657-5
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