Background
Methods
Design
Animals
UCMS (Unpredictable Chronic Mild Stress)
MS (Maternal Separation)
‘Endogenous’ model of depression
mRNA extraction and lab protocols
Human samples
Log 2 fold change | |||||||
---|---|---|---|---|---|---|---|
Transcript | Gene name | Pr. Rsum | c57 | DBA | FVB | 129 | Pfp -Value |
1418687_at |
Arc
| 2,841.834 | -0.242 | -0.279 | -0.221 | -0.127 | <1.00E-04 |
1452453_a_at |
Camk2a
| 2,834.213 | 0.247 | 0.276 | 0.003 | 0.235 | <1.00E-04 |
1427663_a_at |
Clk4
| 4,161.448 | -0.420 | -0.025 | -0.196 | -0.289 | <1.00E-04 |
1436983_at |
Crebbp
| 1,498.852 | 0.600 | 0.156 | 0.176 | 0.566 | <1.00E-04 |
1433733_a_at |
Cry1
| 5,285.620 | 0.438 | 0.113 | 0.070 | 0.238 | <1.00E-04 |
1443805_at |
Dact3
| 4,920.751 | -0.339 | -0.097 | -0.084 | -0.292 | <1.00E-04 |
1438892_at |
Dep1
| 3,046.244 | 0.157 | 0.142 | 0.164 | 0.571 | <1.00E-04 |
1419580_at |
Dlg4
| 3,239.403 | -0.224 | -0.115 | -0.177 | -0.299 | <1.00E-04 |
1453994_at |
Eml6
| 5,673.323 | 0.164 | 0.194 | 0.104 | 0.189 | <1.00E-04 |
1430436_at |
Fam115a
| 4,086.744 | 0.425 | 0.025 | 0.069 | 0.434 | <1.00E-04 |
1418240_at |
Gbp2
| 3,167.576 | -0.183 | -0.368 | -0.335 | -0.169 | <1.00E-04 |
1417949_at |
Ilf2
| 4,243.511 | -0.431 | -0.112 | -0.115 | -0.279 | <1.00E-04 |
1415899_at |
Junb
| 3,330.616 | -0.246 | -0.300 | -0.349 | -0.232 | <1.00E-04 |
1457899_at |
Kalrn
| 4,503.738 | 0.238 | 0.169 | 0.088 | 0.408 | <1.00E-04 |
1438403_s_at |
Malat1
| 1,725.168 | -0.183 | -0.464 | -0.248 | -0.139 | <1.00E-04 |
1419568_at |
Mapk1
| 923.836 | -0.704 | -0.328 | -0.203 | -0.486 | <1.00E-04 |
1420931_at |
Mapk8
| 2,498.977 | -0.336 | -0.180 | -0.268 | -0.193 | <1.00E-04 |
1425459_at |
Mtmr2
| 4,168.453 | -0.344 | -0.198 | -0.206 | -0.236 | <1.00E-04 |
1425014_at |
Nr2c2
| 3,897.542 | 0.420 | 0.016 | 0.169 | 0.421 | <1.00E-04 |
1416505_at |
Nr4a1
| 4,665.395 | -0.234 | -0.148 | -0.225 | -0.161 | <1.00E-04 |
1458176_at |
Per3
| 4,870.404 | 0.269 | 0.168 | 0.106 | 0.222 | <1.00E-04 |
1416211_a_at |
Ptn
| 4,211.224 | -0.439 | -0.151 | -0.176 | -0.225 | <1.00E-04 |
1440001_at |
Rian
| 4,837.821 | 0.284 | 0.070 | 0.192 | 0.279 | <1.00E-04 |
1439940_at |
Slc1a2
| 2,581.498 | 0.547 | 0.079 | 0.059 | 0.441 | <1.00E-04 |
1444489_at |
Slc25a12
| 4,744.455 | 0.293 | 0.077 | 0.117 | 0.197 | <1.00E-04 |
1421924_at |
Slc2a3
| 3,356.425 | -0.435 | -0.125 | -0.202 | 0.000 | <1.00E-04 |
1421225_a_at |
Slc4a4
| 3,960.423 | 0.408 | 0.160 | 0.073 | 0.278 | <1.00E-04 |
1455876_at |
Slc4a7
| 4,614.381 | 0.313 | 0.158 | 0.209 | 0.235 | <1.00E-04 |
1457357_at |
Tlk2
| 3,989.909 | 0.288 | 0.100 | 0.059 | 0.395 | <1.00E-04 |
Statistical analysis of microarray data
Results
Gene expression profiles in ‘reactive’ depression models
Log 2 Fold Change | |||||||
---|---|---|---|---|---|---|---|
Transcript | Gene Name | Pr. Rsum | c57 | DBA | FVB | 129 | Pfp -Value |
1454655_at |
Dgkd
| 3,024.390 | 0.276 | 0.399 | 0.147 | 0.273 | <1.00E-04 |
1450392_at |
Abca1
| 3,716.966 | 0.014 | 0.208 | 0.150 | 0.319 | <1.00E-04 |
1416250_at |
Btg2
| 2,390.318 | -0.346 | -0.301 | -0.161 | -0.500 | <1.00E-04 |
1416332_at |
Cirbp
| 3,963.875 | -0.301 | -0.086 | -0.237 | -0.335 | <1.00E-04 |
1427663_a_at |
Clk4
| 3,977.651 | -0.349 | -0.215 | -0.271 | -0.127 | <1.00E-04 |
1458518_at |
Cpeb2
| 2,642.230 | -0.336 | -0.401 | -0.247 | -0.177 | <1.00E-04 |
1451977_at |
Dyrk1a
| 4,954.256 | -0.133 | -0.206 | -0.235 | -0.168 | <1.00E-04 |
1421142_s_at |
Foxp1
| 3,977.517 | -0.369 | -0.264 | -0.153 | -0.143 | <1.00E-04 |
1439717_at |
Gabrg3
| 5,191.066 | -0.174 | -0.254 | -0.169 | -0.021 | <1.00E-04 |
1422223_at |
Grin2b
| 4,777.728 | -0.220 | -0.129 | -0.225 | -0.223 | <1.00E-04 |
1438441_at |
Id4
| 3,829.228 | 0.313 | 0.324 | 0.290 | 0.046 | <1.00E-04 |
1420931_at |
Mapk8
| 2,623.666 | -0.158 | -0.373 | -0.164 | -0.333 | <1.00E-04 |
1425459_at |
Mtmr2
| 4,660.997 | -0.283 | -0.212 | -0.165 | -0.169 | <1.00E-04 |
1437660_at |
Nktr
| 5,633.677 | -0.089 | -0.008 | -0.178 | -0.226 | <1.00E-04 |
1443970_at |
Ntrk3
| 3,929.819 | 0.261 | 0.388 | 0.117 | 0.254 | <1.00E-04 |
1437213_at |
Nudt21
| 4,091.995 | 0.234 | 0.294 | 0.040 | 0.018 | <1.00E-04 |
1453750_x_at |
Pitpnc1
| 5,481.080 | -0.305 | -0.146 | -0.065 | -0.179 | <1.00E-04 |
1418015_at |
Pum2
| 3,066.939 | -0.032 | -0.362 | -0.146 | -0.438 | <1.00E-04 |
1428462_at |
Ppp2r5e
| 5,555.808 | -0.212 | -0.192 | -0.085 | -0.273 | <1.00E-04 |
1428905_at |
Rraga
| 2,709.505 | -0.266 | -0.447 | -0.169 | -0.322 | <1.00E-04 |
1421346_a_at |
Slc6a6
| 2,560.666 | -0.421 | -0.418 | -0.238 | -0.333 | <1.00E-04 |
1420867_at |
Tmed2
| 2,172.246 | -0.329 | -0.291 | -0.457 | -0.250 | <1.00E-04 |
1435770_at |
Tmx4
| 4,098.309 | -0.197 | -0.078 | -0.313 | -0.140 | <1.00E-04 |
1459737_s_at |
Ttr
| 1,229.204 | 0.678 | 0.186 | 0.074 | 0.376 | <1.00E-04 |
1420833_at |
Vamp2
| 3,820.922 | -0.133 | -0.172 | -0.256 | -0.244 | <1.00E-04 |
1450308_a_at |
Xrn1
| 2,743.074 | -0.175 | -0.373 | -0.340 | -0.306 | <1.00E-04 |
1420816_at |
Ywhag
| 1,838.774 | -0.265 | -0.294 | -0.419 | -0.362 | <1.00E-04 |
1448219_a_at |
Ywhaz
| 3,773.496 | -0.314 | -0.283 | -0.323 | -0.252 | <1.00E-04 |
Gene expression profiles in ‘endogenous’ depression models
Translating findings to humans
Probe Set ID | Gene symbol | RP/Rsum |
PFP
|
P-value |
---|---|---|---|---|
1034_at |
TIMP3
| 10.3564 | 1.0512 | 0.6398 |
1035_g_at |
TIMP3
| 10.788 | 0.9069 | 0.7097 |
1235_at |
YWHAZ
| 8.1361 | 1.8677 | 0.2436 |
2018_at |
GJA1
| 10.6102 | 0.9224 | 0.6818 |
296_at |
TUBB2A
| 8.1718 | 1.4332 | 0.2493 |
297_g_at |
TUBB2A
| 10.38 | 0.9872 | 0.6438 |
32254_at |
VAMP2
| 9.7002 | 0.0024 | 0.5228 |
32531_at |
GJA1
| 5.6354 | 0.4128 | 0.018 |
32572_at |
USP9X
| 9.6037 | 1.0556 | 0.5049 |
32761_at |
SRRM2
| 11.6727 | 0.9074 | 0.8285 |
34387_at |
LPGAT1
| 10.5963 | 0.9769 | 0.6796 |
34642_at |
YWHAZ
| 6.7492 | 0.8804 | 0.0766 |
36307_at |
ARC
| 8.5526 | 1.0273 | 0.3127 |
36760_at |
YWHAZ
| 9.8422 | 0.9712 | 0.5489 |
38211_at |
ZBTB20
| 8.6008 | 0.8204 | 0.321 |
38710_at |
OTUB1
| 9.566 | 1.145 | 0.4978 |
39331_at |
TUBB2A
| 8.2579 | 1.2097 | 0.263 |
39725_at |
RBM39
| 10.946 | 0.888 | 0.7336 |
40096_at |
ATP5A1
| 8.5727 | 0.9088 | 0.3161 |
40125_at |
CANX
| 8.2587 | 1.0086 | 0.2631 |
968_i_at |
USP9X
| 11.0827 | 0.8662 | 0.7532 |