04.03.2020 | Original Article
The epidemiology of NAFLD in Mainland China with analysis by adjusted gross regional domestic product: a meta-analysis
verfasst von:
Yuankai Wu, Qi Zheng, Biyao Zou, Yee Hui Yeo, Xiaohe Li, Jie Li, Xiaoyu Xie, Yuemin Feng, Christopher Donald Stave, Qiang Zhu, Ramsey Cheung, Mindie H. Nguyen
Erschienen in:
Hepatology International
|
Ausgabe 2/2020
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Abstract
Background
Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease worldwide. This study aimed to estimate the prevalence, incidence, and outcome of NAFLD in the large and diverse population of Mainland China.
Methods
PubMed, Embase, and the Cochrane Library databases were searched to identify published studies with NAFLD epidemiology data in adult participants (≥ 18 years old) from Mainland China. Random effects models were used to determine pooled estimates.
Results
We screened 1,328 studies and included 167 eligible studies (participant n = 1,486,635): 149 studies (n = 1,350,819) for prevalence, 18 studies (n = 147,316) for incidence, 7 studies (n = 5446) for evolution of hepatic steatosis, and 2 studies (n = 647) for mortality analysis. The NAFLD prevalence of the overall populations was 29.88%, with higher rates in males, increasing age and increasing gross regional domestic product (GRDP) per capita (all p ≤ 0.010). The prevalence was the highest in North China (36.41%; higher in Uyghur and Hui Chinese 40.86% and 34.36% vs 28.11% in Han Chinese), higher in diabetics (51.83% vs. 30.76% in non-diabetics) and in obese participants (66.21% vs. 11.72% in lean). The NAFLD incidence was 56.7 (95% CI 47.4–66.8) per 1000 person-years, higher in males and with higher GRDP per capita. The overall mortality was 7.3 (3.3–12.7) per 1000 person-years.
Conclusions
The overall prevalence of NAFLD in Mainland China is about 30%. The highest prevalences were found among regions with higher income, North China, the non-Han ethnic minorities, diabetics, and the obese. China’s NAFLD prevalence is on par with Western countries.