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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Oral Health 1/2015

The evaluation of endodontic flare-ups and their relationship to various risk factors

BMC Oral Health > Ausgabe 1/2015
Emel Olga Onay, Mete Ungor, A. Canan Yazici
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

EOO conceived the study, EOO, MU carried out the study. ACY transferred all data received from clinic to SPSS and EXCEL and performed all statistical analyses. EOO, MU and ACY participated in drafting the manuscript. All authors revised and agreed on the final draft. All authors read and approved the final manuscript.



To evaluate the incidence of flare-ups and identify the risk factors including age, gender, tooth type, number of root canals, initial diagnosis, the type of irrigation regimen, treatment modality and the number of visits, in patients who received root canal treatment from January 2002 to January 2008.


Records of 1819 teeth belonging to 1410 patients treated by 1 endodontics specialist during 6-year period were kept. Patient, tooth, and treatment characteristics were evaluated and the relationships between these characteristics and flare-ups were studied. Statistical analysis was carried out by using Pearson Chi-square test, Fisher’s Exact test, and Binary Logistic regression analyses.


The incidence of flare-ups was 59 (3.2 %) out of 1819 teeth that received endodontic therapy. Pulpal necrosis without periapical pathosis was the most common indication for flare-up (6 %) (p < 0.01). Teeth undergoing multiple visits had a higher risk of developing flare-ups compared to those with single appointments (OR: 3.14, CI: 1.414–7.009, p < 0.01). There were also no statistically significant differences in the incidence of flare-ups regarding to age, gender, tooth type, number of root canals, treatment modality, and the irrigation solutions that used during the treatment.


The incidence of flare-up is minimal when teeth are treated in one visit. Absence of a periapical lesion in necrotic teeth is a significant risk factor for flare-ups.
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