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Journal of Neuro-Oncology

Erschienen in:

06.04.2017 | Topic Review

The evolving role for re-irradiation in the management of recurrent grade 4 glioma

verfasst von: Steven P. Howard, Andra Krauze, Mike D. Chan, Christina Tsien, Wolfgang A. Tomé

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2017

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Abstract

Although significant gains have been realized in the management of grade 4 glioma, the majority of these patients will ultimately suffer local recurrence within the prior field of treatment. Clearly, novel local treatment strategies are required to improve patient outcomes. Concerns of toxicity have limited enthusiasm for the utilization of re-irradiation as a treatment option. However, using modern imaging technology and precision radiotherapy delivery techniques re-irradiation has proven a feasible option achieving both a palliative benefit and prolongation of survival with low toxicity rates. The evolution of re-irradiation as a treatment modality for recurrent grade 4 glioma is reviewed. In addition, potential targeted radiosensitizers to be used in conjunction with re-irradiation are also discussed.

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Titel: The evolving role for re-irradiation in the management of recurrent grade 4 glioma
verfasst von: Steven P. Howard
Andra Krauze
Mike D. Chan
Christina Tsien
Wolfgang A. Tomé
Publikationsdatum: 06.04.2017
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 3/2017
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-017-2392-1

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