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Current Oncology Reports

Erschienen in:

01.08.2020 | Sarcomas (SR Patel, Section Editor)

The Evolving Role of Radiation Therapy in Patients with Metastatic Soft Tissue Sarcoma

verfasst von: Ahsan Farooqi, Devarati Mitra, B. Ashleigh Guadagnolo, Andrew J. Bishop

Erschienen in: Current Oncology Reports | Ausgabe 8/2020

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Abstract

Purpose of Review

The management of metastatic disease is evolving. As systemic therapies continue to improve, there is increasing recognition that local therapy to distant sites of disease impacts outcomes among many histologies, including sarcoma. Various local therapy strategies exist, but radiation therapy (RT) is particularly critical as it provides a non-invasive, yet locally ablative strategy for metastatic management.

Recent Findings

Various delivery techniques including stereotactic body radiation therapy (SBRT) or hypofractionated RT can escalate the biologic dose while avoiding normal tissues in order to reduce tumor burden, provide durable local control, palliate symptoms, potentially prevent further seeding of metastatic lesions, and potentially prolong survival.

Summary

This review summarizes the current state of the literature on the important role of RT for the treatment of metastatic sarcoma organized by the site of metastatic disease. Particularly for patients presenting with oligometastatic or oligoprogressive disease, consolidative RT is an important local therapy strategy to be considered in a multidisciplinary setting.

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Titel: The Evolving Role of Radiation Therapy in Patients with Metastatic Soft Tissue Sarcoma
verfasst von: Ahsan Farooqi
Devarati Mitra
B. Ashleigh Guadagnolo
Andrew J. Bishop
Publikationsdatum: 01.08.2020
Verlag: Springer US
Erschienen in: Current Oncology Reports / Ausgabe 8/2020
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-020-00936-5

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