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Erschienen in: Brain Structure and Function 1/2017

18.04.2016 | Original Article

The extracellular matrix glycoprotein tenascin-C and matrix metalloproteinases modify cerebellar structural plasticity by exposure to an enriched environment

verfasst von: Vera Stamenkovic, Stefan Stamenkovic, Tomasz Jaworski, Maciej Gawlak, Milos Jovanovic, Igor Jakovcevski, Grzegorz M. Wilczynski, Leszek Kaczmarek, Melitta Schachner, Lidija Radenovic, Pavle R. Andjus

Erschienen in: Brain Structure and Function | Ausgabe 1/2017

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Abstract

The importance of the extracellular matrix (ECM) glycoprotein tenascin-C (TnC) and the ECM degrading enzymes, matrix metalloproteinases (MMPs) -2 and -9, in cerebellar histogenesis is well established. This study aimed to examine whether there is a functional relationship between these molecules in regulating structural plasticity of the lateral deep cerebellar nucleus. To this end, starting from postnatal day 21, TnC- or MMP-9-deficient mice were exposed to an enriched environment (EE). We show that 8 weeks of exposure to EE leads to reduced lectin-based staining of perineuronal nets (PNNs), reduction in the size of GABAergic and increase in the number and size of glutamatergic synaptic terminals in wild-type mice. Conversely, TnC-deficient mice showed reduced staining of PNNs compared to wild-type mice maintained under standard conditions, and exposure to EE did not further reduce, but even slightly increased PNN staining. EE did not affect the densities of the two types of synaptic terminals in TnC-deficient mice, while the size of inhibitory, but not excitatory synaptic terminals was increased. In the time frame of 4–8 weeks, MMP-9, but not MMP-2, was observed to influence PNN remodeling and cerebellar synaptic plasticity as revealed by measurement of MMP-9 activity and colocalization with PNNs and synaptic markers. These findings were supported by observations on MMP-9-deficient mice. The present study suggests that TnC contributes to the regulation of structural plasticity in the cerebellum and that interactions between TnC and MMP-9 are likely to be important for these processes to occur.
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Metadaten
Titel
The extracellular matrix glycoprotein tenascin-C and matrix metalloproteinases modify cerebellar structural plasticity by exposure to an enriched environment
verfasst von
Vera Stamenkovic
Stefan Stamenkovic
Tomasz Jaworski
Maciej Gawlak
Milos Jovanovic
Igor Jakovcevski
Grzegorz M. Wilczynski
Leszek Kaczmarek
Melitta Schachner
Lidija Radenovic
Pavle R. Andjus
Publikationsdatum
18.04.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Brain Structure and Function / Ausgabe 1/2017
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-016-1224-y

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