The online version of this article (doi:10.1186/1475-2875-11-285) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
MM was the reference clinician attending the patient, performed the bone marrow biopsy, and reviewed the manuscript. CS performed the cytological analyses and reviewed the manuscript. FC performed pathological analyses, including immunochemistry of the bone marrow biopsy and reviewed the manuscript. EF and PB performed parasitological and pathological analyses and wrote the manuscript. All authors read and approved the final manuscript.
Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear.
The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria.
A majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces.
These observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.
Dearnley MK, Yeoman JA, Hanssen E, Kenny S, Turnbull L, Whitchurch CB, Tilley L, Dixon MW: Origin, composition, organization and function of the inner membrane complex of Plasmodium falciparum gametocytes. J Cell Sci. 2012, 10.1242/jcs.099002.
Tibúrcio M, Niang M, Deplaine G, Perrot S, Bischoff E, Ndour A, Silvestrini F, Khattab A, Milon G, David P, Hardeman M, Vernick KD, Sauerwein RW, Preiser PR, Mercereau-Puijalon O, Buffet P, Alano P, Lavazec C: A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages. Blood. 2012, 10.1182/blood-2012-03-414557.
- The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?
- BioMed Central
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