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Erschienen in: World Journal of Urology 11/2020

29.11.2019 | Original Article

The fate of urological systematic reviews registered in PROSPERO

verfasst von: Sari Khaleel, Brent Cleveland, Arveen Kalapara, Niranjan Sathianathen, Priyamvadha Balaji, Philipp Dahm

Erschienen in: World Journal of Urology | Ausgabe 11/2020

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Abstract

Purpose

To identify urologic systematic reviews (SRs) registered to PROSPERO that resulted in a publication, and to evaluate their methodological quality and concordance with their stated a priori protocols.

Methods

We searched PubMed to identify urologic SR protocols registered in PROSPERO that resulted in a publication and assessed their methodological quality and protocols in relation to their stated a priori protocols in PROSPERO.

Results

Of the 576 urologic SR protocols registered in PROSPERO up to December 2017, 201 (34.9%) resulted in a full SR publication, but only 40 (17.7%) updated their registration record accordingly. Publications were spread over 100 different journals, with a median time-to-publication of 29 months (95% CI 25.0–33.0). The most common topic by far was prostate cancer (59.7%), followed by voiding issues (15.3%), and renal transplantation (15.3%). Only little over half the reviews (52.74%) explicitly stated primary outcome(s) that matched the primary outcome of their corresponding PROSPERO protocol. Notable methodologic deviations from registered protocols included planned restriction on study design (33%), heterogeneity analysis (42%) and planned risk of bias analysis (65.2%).

Conclusion

SR authors in urology are increasingly using PROSPERO to register their titles, but our findings indicate that registration alone is not a guarantor of a high-quality SR product. There appears to be a critical need to raise the bar for review authors registering protocols in PROSPERO, with an emphasis on transparency in their publication status updates as well as deviations from their a priori protocols.
Literatur
Metadaten
Titel
The fate of urological systematic reviews registered in PROSPERO
verfasst von
Sari Khaleel
Brent Cleveland
Arveen Kalapara
Niranjan Sathianathen
Priyamvadha Balaji
Philipp Dahm
Publikationsdatum
29.11.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
World Journal of Urology / Ausgabe 11/2020
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-019-03032-x

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