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01.09.2018 | Original Research

The Feelings About genomiC Testing Results (FACToR) Questionnaire: Development and Preliminary Validation

verfasst von: Meng Li, Caroline S. Bennette, Laura M. Amendola, M. Ragan Hart, Patrick Heagerty, Bryan Comstock, Peter Tarczy-Hornoch, Stephanie M. Fullerton, Dean A. Regier, Wylie Burke, Susan B. Trinidad, Gail P. Jarvik, David L. Veenstra, Donald L. Patrick

Erschienen in: Journal of Genetic Counseling

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Abstract

The purpose of this study was to develop a brief instrument, the Feelings About genomiC Testing Results (FACToR), to measure the psychosocial impact of returning genomic findings to patients in research and clinical practice. To create the FACToR, we modified and augmented the Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire based on findings from a literature review, two focus groups (N = 12), and cognitive interviews (N = 6). We evaluated data from 122 participants referred for evaluation for inherited colorectal cancer or polyposis from the New EXome Technology in (NEXT) Medicine Study, an RCT of exome sequencing versus usual care. We assessed floor and ceiling effects of each item, conducted principal component analysis to identify subscales, and evaluated each subscale’s internal consistency, test-retest reliability, and construct validity. After excluding items that were ambiguous or demonstrated floor or ceiling effects, 12 items forming four distinct subscales were retained for further analysis: negative emotions, positive feelings, uncertainty, and privacy concerns. All four showed good internal consistency (0.66–0.78) and test-retest reliability (0.65–0.91). The positive feelings and the uncertainty subscales demonstrated known-group validity. The 12-item FACToR with four subscales shows promising psychometric properties on preliminary evaluation in a limited sample and needs to be evaluated in other populations.

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Titel: The Feelings About genomiC Testing Results (FACToR) Questionnaire: Development and Preliminary Validation
verfasst von: Meng Li
Caroline S. Bennette
Laura M. Amendola
M. Ragan Hart
Patrick Heagerty
Bryan Comstock
Peter Tarczy-Hornoch
Stephanie M. Fullerton
Dean A. Regier
Wylie Burke
Susan B. Trinidad
Gail P. Jarvik
David L. Veenstra
Donald L. Patrick
Publikationsdatum: 01.09.2018
Verlag: Springer US
Erschienen in: Journal of Genetic Counseling
Print ISSN: 1059-7700
Elektronische ISSN: 1573-3599
DOI: https://doi.org/10.1007/s10897-018-0286-9

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The Feelings About genomiC Testing Results (FACToR) Questionnaire: Development and Preliminary Validation

Abstract

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Neu im Fachgebiet Gynäkologie und Geburtshilfe

Manche Gestagene können das Risiko für Meningeome erhöhen

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Chronische Schmerzen nach Op. oft mit neuropathischer Komponente

Das Ende der vollständigen axillären Lymphknotendissektion

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