The First Human Application of an F-18-Labeled Tryptophan Analog for PET Imaging of Cancer
- 27.11.2023
- Brief Article
Erschienen in:
- Verfasst von
- Otto Muzik
- Anthony F. Shields
- Geoffrey R. Barger
- Huailei Jiang
- Parthasarathi Chamiraju
- Csaba Juhász
- Erschienen in
- Molecular Imaging and Biology | Ausgabe 1/2024
Abstract
Purpose
Preclinical studies showed the tryptophan analog PET radiotracer 1-(2-18F-fluoroethyl)-L-tryptophan (18F-FETrp) to accumulate in various tumors, including gliomas, and being metabolized via the immunosuppressive kynurenine pathway. In this first-in-human study, we tested the use 18F-FETrp-PET in patients with neuroendocrine and brain tumors.
Procedures
We applied dynamic brain imaging in patients with gliomas (n = 2) and multi-pass 3D whole-body PET scans in patients with neuroendocrine tumors (n =4). Semiquantitative analysis of organ and tumor tracer uptake was performed using standardized uptake values (SUVs). In addition, organ dosimetry was performed based on extracted time–activity curves and the OLINDA software.
Results
Neuroendocrine tumors showed an early peak (10-min post-injection) followed by washout. Both gliomas showed prolonged 18F-FETrp accumulation plateauing around 40 min and showing heterogeneous uptake including non-enhancing tumor regions. Biodistribution showed moderate liver uptake and fast clearance of radioactivity into the urinary bladder; the estimated effective doses were similar to other 18F-labeled radioligands.
Conclusions
The study provides proof-of-principle data for the safety and potential clinical value of 18F-FETrp-PET for molecular imaging of human gliomas.
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- Titel
- The First Human Application of an F-18-Labeled Tryptophan Analog for PET Imaging of Cancer
- Verfasst von
-
Otto Muzik
Anthony F. Shields
Geoffrey R. Barger
Huailei Jiang
Parthasarathi Chamiraju
Csaba Juhász
- Publikationsdatum
- 27.11.2023
- Verlag
- Springer International Publishing
- Erschienen in
-
Molecular Imaging and Biology / Ausgabe 1/2024
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002 - DOI
- https://doi.org/10.1007/s11307-023-01877-8
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