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Erschienen in:

16.07.2021 | Review Article

The Function and Therapeutic Potential of Circular RNA in Cardiovascular Diseases

verfasst von: Kai Wang, Xiang-Qian Gao, Tao Wang, Lu-Yu Zhou

Erschienen in: Cardiovascular Drugs and Therapy | Ausgabe 1/2023

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Abstract

Circular RNA (circRNA) has a closed-loop structure, and its 3’ and 5’ ends are directly covalently connected by reverse splicing, which is more stable than linear RNA. CircRNAs usually possess microRNA (miRNA) binding sites, which can bind miRNAs and inhibit miRNA function. Many studies have shown that circRNAs are involved in the processes of cell senescence, proliferation and apoptosis and a series of signalling pathways, playing an important role in the prevention and treatment of diseases. CircRNAs are potential biological diagnostic markers and therapeutic targets for cardiovascular diseases (CVDs). To identify biomarkers and potential effective therapeutic targets without toxicity for heart disease, we summarize the biogenesis, biology, characterization and functions of circRNAs in CVDs, hoping that this information will shed new light on the prevention and treatment of CVDs.

Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, et al. Circular rnas are a large class of animal rnas with regulatory potency. Nature. 2013;495(7441):333–8.CrossRef

Sanger HL, Klotz G, Riesner D, Gross HJ, Kleinschmidt AK. Viroids are single-stranded covalently closed circular rna molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci U S A. 1976;73(11):3852–6.CrossRef

Hsu MT, Coca-Prados M. Electron microscopic evidence for the circular form of rna in the cytoplasm of eukaryotic cells. Nature. 1979;280(5720):339–40.CrossRef

Capel B, Swain A, Nicolis S, Hacker A, Walter M, Koopman P, et al. Circular transcripts of the testis-determining gene sry in adult mouse testis. Cell. 1993;73(5):1019–30.CrossRef

Cocquerelle C, Mascrez B, Hétuin D, Bailleul B. Mis-splicing yields circular rna molecules. FASEB J. 1993;7(1):155–60.CrossRef

Chen X, Han P, Zhou T, Guo X, Song X, Li Y. Circrnadb: a comprehensive database for human circular rnas with protein-coding annotations. Sci Rep. 2016;6:34985.CrossRef

Abdelmohsen K, Panda A, Munk R, Grammatikakis I, Dudekula D, De S, et al. Identification of hur target circular rnas uncovers suppression of pabpn1 translation by circpabpn1. RNA Biol. 2017;14(3):361–9.CrossRef

Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, et al. Circrna biogenesis competes with pre-mrna splicing. Mol Cell. 2014;56(1):55–66.CrossRef

Ying C, Guohai Y, Ye Z, et al. High glucose-induced circhipk3 downregulation mediates endothelial cell injury. Biochem Biophys Res Commun. 2018;507(1–4):362–8.

10.

Lu D, Thum T. Rna-based diagnostic and therapeutic strategies for cardiovascular disease. Nat Rev Cardiol. 2019;16(11):661–74.CrossRef

11.

Zhang TR, Huang WQ. Angiogenic circular rnas: a new landscape in cardiovascular diseases. Microvasc Res. 2020;129:103983.CrossRef

12.

Chen I, Chen CY, Chuang TJ. Biogenesis, identification, and function of exonic circular rnas. Wiley Interdiscip Rev RNA. 2015;6(5):563–79.CrossRef

13.

Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, et al. Exon-intron circular rnas regulate transcription in the nucleus. Nat Struct Mol Biol. 2015;22(3):256–64.CrossRef

14.

Kelly SGC, Cook PR, Papantonis A. Exon skipping is correlated with exon circularization. J Mol Biol. 2015;427(15):2414–7.CrossRef

15.

Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, et al. Circular intronic long noncoding rnas. Mol Cell. 2013;51(6):792–806.CrossRef

16.

Vo J, Cieslik M, Zhang Y, Shukla S, Xiao L, Zhang Y, et al. The landscape of circular rna in cancer. Cell. 2019;176(4):869-81.e13.CrossRef

17.

Suzuki H, Tsukahara T. A view of pre-mrna splicing from rnase r resistant rnas. Int J Mol Sci. 2014;15(6):9331–42.CrossRef

18.

Du W, Yang W, Chen Y, Wu Z, Foster F, Yang Z, et al. Foxo3 circular rna promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J. 2017;38(18):1402–12.

19.

Cai J, Chen Z, Wang J, Wang J, Chen X, Liang L, et al. Circhectd1 facilitates glutaminolysis to promote gastric cancer progression by targeting mir-1256 and activating β-catenin/c-myc signaling. Cell Death Dis. 2019;10(8):576.CrossRef

20.

Qu S, Liu Z, Yang X, Zhou J, Yu H, Zhang R, et al. The emerging functions and roles of circular rnas in cancer. Cancer Lett. 2018;414:301–9.CrossRef

21.

Wen G, Zhou T, Gu W. The potential of using blood circular rna as liquid biopsy biomarker for human diseases. Protein Cell. 2020.

22.

Huang A, Zheng H, Wu Z, Chen M, Huang Y. Circular rna-protein interactions: functions, mechanisms, and identification. Theranostics. 2020;10(8):3503–17.CrossRef

23.

Hansen T, Wiklund E, Bramsen J, Villadsen S, Statham A, Clark S, et al. Mirna-dependent gene silencing involving ago2-mediated cleavage of a circular antisense rna. EMBO J. 2011;30(21):4414–22.CrossRef

24.

Park O, Ha H, Lee Y, Boo S, Kwon D, Song H, et al. Endoribonucleolytic cleavage of ma-containing rnas by rnase p/mrp complex. Mol Cell. 2019;74(3):494-507.e8.CrossRef

25.

Fischer J, Busa V, Shao Y, Leung A. Structure-mediated rna decay by upf1 and g3bp1. Mol Cell. 2020;78(1):70-84.e6.CrossRef

26.

Jia R, Xiao M, Li Z, Shan G, Huang C. Defining an evolutionarily conserved role of gw182 in circular rna degradation. Cell Discov. 2019;5:45.CrossRef

27.

Liu C, Li X, Nan F, Jiang S, Gao X, Guo S, et al. Structure and degradation of circular rnas regulate pkr activation in innate immunity. Cell. 2019;177(4):865-80.e21.CrossRef

28.

Liang D, Tatomer DC, Luo Z, Wu H, Yang L, Chen L-L, et al. The output of protein-coding genes shifts to circular rnas when the pre-mrna processing machinery is limiting. Mol Cell. 2017;68(5):940-54.e3.CrossRef

29.

Beermann J, Piccoli M, Viereck J, Thum T. Non-coding rnas in development and disease: background, mechanisms, and therapeutic approaches. Physiol Rev. 2016;96(4):1297–325.CrossRef

30.

Ebert MS, Neilson JR, Sharp PA. Microrna sponges: competitive inhibitors of small rnas in mammalian cells. Nat Methods. 2007;4(9):721–6.CrossRef

31.

Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP. A coding-independent function of gene and pseudogene mrnas regulates tumour biology. Nature. 2010;465(7301):1033–8.CrossRef

32.

Zhao F, Chen T, Jiang N. Cdr1as/mir-7/ckap4 axis contributes to the pathogenesis of abdominal aortic aneurysm by regulating the proliferation and apoptosis of primary vascular smooth muscle cells. Exp Ther Med. 2020;19(6):3760–6.

33.

Piwecka M, Glazar P, Hernandez-Miranda LR, Memczak S, Wolf SA, Rybak-Wolf A, et al. Loss of a mammalian circular rna locus causes mirna deregulation and affects brain function. Science. 2017;357(6357):eaam8526.CrossRef

34.

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, et al. Natural rna circles function as efficient microrna sponges. Nature. 2013;495(7441):384–8.CrossRef

35.

Quan H, Chen Q, Wang K, Wang Q, Lu M, Zhang Y, et al. Exendin-4 reversed the pc12 cell damage induced by circrna cdr1as/mir-671/gsk3β signaling pathway. J Mol Neurosci. 2020;71(4):778–89.CrossRef

36.

Dang R, Liu F, Li Y. Circular rna hsa_circ_0010729 regulates vascular endothelial cell proliferation and apoptosis by targeting the mir-186/hif-1α axis. Biochem Biophys Res Commun. 2017;490(2):104–10.CrossRef

37.

Zhuang J, Li T, Hu X, Ning M, Gao W, Lang Y, et al. Circ_chfr expedites cell growth, migration and inflammation in ox-ldl-treated human vascular smooth muscle cells via the mir-214-3p/wnt3/β-catenin pathway. Eur Rev Med Pharmacol Sci. 2020;24(6):3282–92.

38.

Bressin A, Schulte-Sasse R, Figini D, Urdaneta EC, Beckmann BM, Marsico A. Tripepsvm: de novo prediction of rna-binding proteins based on short amino acid motifs. Nucleic Acids Res. 2019;47(9):4406–17. CrossRef

39.

Zang J, Lu D, Xu A. The interaction of circrnas and rna binding proteins: an important part of circrna maintenance and function. J Neurosci Res. 2020;98(1):87–97.CrossRef

40.

Ma S, Kong S, Wang F, Ju S. Circrnas: biogenesis, functions, and role in drug-resistant tumours. Mol Cancer. 2020;19(1):119.CrossRef

41.

Zeng Y, Du W, Wu Y, Yang Z, Awan F, Li X, et al. A circular rna binds to and activates akt phosphorylation and nuclear localization reducing apoptosis and enhancing cardiac repair. Theranostics. 2017;7(16):3842–55.CrossRef

42.

Conn S, Pillman K, Toubia J, Conn V, Salmanidis M, Phillips C, et al. The rna binding protein quaking regulates formation of circrnas. Cell. 2015;160(6):1125–34.CrossRef

43.

Holdt L, Stahringer A, Sass K, Pichler G, Kulak N, Wilfert W, et al. Circular non-coding rna anril modulates ribosomal rna maturation and atherosclerosis in humans. Nat Commun. 2016;7:12429.CrossRef

44.

Abe N, Matsumoto K, Nishihara M, Nakano Y, Shibata A, Maruyama H, et al. Rolling circle translation of circular rna in living human cells. Sci Rep. 2015;5:16435.CrossRef

45.

Santer L, Bär C, Thum T. Circular rnas: a novel class of functional rna molecules with a therapeutic perspective. Mol Ther. 2019;27(8):1350–63.CrossRef

46.

Lei M, Zheng G, Ning Q, Zheng J, Dong D. Translation and functional roles of circular rnas in human cancer. Mol Cancer. 2020;19(1):30.CrossRef

47.

Pamudurti N, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, et al. Translation of circrnas. Mol Cell. 2017;66(1):9-21.e7.CrossRef

48.

Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, et al. Circ-znf609 is a circular rna that can be translated and functions in myogenesis. Mol Cell. 2017;66(1):22-37.e9.CrossRef

49.

van Heesch S, Witte F, Schneider-Lunitz V, Schulz J, Adami E, Faber A, et al. The translational landscape of the human heart. Cell. 2019;178(1):242-60.e29.CrossRef

50.

Liu J, Liu T, Wang X, He A. Circles reshaping the rna world: from waste to treasure. Mol Cancer. 2017;16(1):58.CrossRef

51.

McAloon C, Boylan L, Hamborg T, Stallard N, Osman F, Lim P, et al. The changing face of cardiovascular disease 2000–2012: an analysis of the world health organisation global health estimates data. Int J Cardiol. 2016;224:256–64.CrossRef

52.

Members WG, Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, et al. Heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation. 2016;133(4):e38.

53.

Geng HH, Rui L, Su YM, Jie X, Min P, Cai XX, et al. The circular rna cdr1as promotes myocardial infarction by mediating the regulation of mir-7a on its target genes expression. Plos One. 2016;11(3):e0151753.CrossRef

54.

Wang K, Gan T-Y, Li N, Liu C-Y, Zhou L-Y, Gao J-N, et al. Circular rna mediates cardiomyocyte death via mirna-dependent upregulation of mtp18 expression. Cell Death Differ. 2017;24(6):1111–20.CrossRef

55.

Lidong Cai, Baozhen Qi, Xiaoyu Wu, et al. Circular rna ttc3 regulates cardiac function after myocardial infarction by sponging mir-15b. J Mol Cell Cardiol. 2019;130:10–22.CrossRef

56.

Huang S, Li X, Zheng H, Si X, Li B, Wei G, et al. Loss of super-enhancer-regulated circrna nfix induces cardiac regeneration after myocardial infarction in adult mice. Circulation. 2019;139(25):2857–76.CrossRef

57.

Li M, Ding W, Tariq MA, Chang W, Zhang X, Xu W, et al. A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting mir-133a-3p. Theranostics. 2018;8(21):5855–69.CrossRef

58.

Zhou L-Y, Zhai M, Huang Y, Sheng Xu, An T, Wang Y-H, et al. The circular rna acr attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the pink1/fam65b pathway. Cell Death Differ. 2018;26(7):1299–315.CrossRef

59.

Li Y, Ren S, Xia J, Wei Y, Xi Y. Eif4a3-induced circ-bnip3 aggravated hypoxia-induced injury of h9c2 cells by targeting mir-27a-3p/bnip3. Mol Ther Nucleic Acids. 2020;19:533–45.CrossRef

60.

Salgado-Somoza A, Zhang L, Vausort M, Devaux Y. The circular rna micra for risk stratification after myocardial infarction. International journal of cardiology. Heart Vasc. 2017;17:33–6.CrossRef

61.

Bai X, Niu R, Liu J, Pan X, Wang F, Yang W, et al. Roles of noncoding rnas in the initiation and progression of myocardial ischemia-reperfusion injury. Epigenomics. 2021;13(9):715–43.CrossRef

62.

Song Y, Zhao L, Wang B, Sun J, Hu J, Zhu X, et al. The circular rna tlk1 exacerbates myocardial ischemia/reperfusion injury via targeting mir-214/ripk1 through tnf signaling pathway. Free Radical Biol Med. 2020;155:69–80.CrossRef

63.

Chen L, Luo W, Zhang W, Chu H, Wang J, Dai X, et al. Circdlpag4/hectd1 mediates ischaemia/reperfusion injury in endothelial cells via er stress. RNA Biol. 2020;17(2):240–53.CrossRef

64.

Xiao Y, Oumarou DB, Wang S, Liu Y. Circular rna involved in the protective effect of Malva sylvestris l. On myocardial ischemic/re-perfused injury. Front Pharmacol. 2020;11:520486.CrossRef

65.

Altesha M, Ni T, Khan A, Liu K, Zheng X. Circular rna in cardiovascular disease. J Cell Physiol. 2019;234(5):5588–600.CrossRef

66.

Zhang CL, Long TY, Bi SS, Sheikh SA, Li F. Circpan3 ameliorates myocardial ischaemia/reperfusion injury by targeting mir-421/pink1 axis-mediated autophagy suppression. Lab Invest. 2021;101(1):89–103.CrossRef

67.

Wang K, Long B, Liu F, Wang J, Liu C, Zhao B, et al. A circular rna protects the heart from pathological hypertrophy and heart failure by targeting mir-223. Eur Heart J. 2016;37(33):2602–11.CrossRef

68.

Lim T, Aliwarga E, Luu T, Li Y, Ng S, Annadoray L, et al. Targeting the highly abundant circular rna circslc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy. Cardiovasc Res. 2019;115(14):1998–2007.CrossRef

69.

Zhang Y, Chen B. Silencing circ_0062389 alleviates cardiomyocyte apoptosis in heart failure rats via modulating tgf-β1/smad3 signaling pathway. Gene. 2021;766:145154.CrossRef

70.

Han J, Zhang L, Hu L, Yu H, Xu F, Yang B, et al. Circular rna-expression profiling reveals a potential role of hsa_circ_0097435 in heart failure via sponging multiple micrornas. Front Genet. 2020;11:212.CrossRef

71.

Deng Y, Wang J, Xie G, Zeng X, Li H. Circ-hipk3 strengthens the effects of adrenaline in heart failure by mir-17-3p - adcy6 axis. Int J Biol Sci. 2019;15(11):2484–96.CrossRef

72.

Zaiou M. Circular rnas as potential biomarkers and therapeutic targets for metabolic diseases. Adv Exp Med Biol. 2019;1134:177–91.CrossRef

73.

Zaiou M. Circular rnas in hypertension: challenges and clinical promise. Hypertens Res. 2019;42(11):1653–63.CrossRef

74.

Zhang S, Chen X, Li C, Li X, Liu C, Liu B, et al. Identification and characterization of circular rnas as a new class of putative biomarkers in diabetes retinopathy. Invest Ophthalmol Vis Sci. 2017;58(14):6500–9.CrossRef

75.

Zhou B, Yu J. A novel identified circular rna, circrna_010567, promotes myocardial fibrosis via suppressing mir-141 by targeting tgf-β1. Biochem Biophys Res Commun. 2017;487(4):769–75.CrossRef

76.

Yang F, Li A, Qin Y, Che H, Wang Y, Lv J, et al. A novel circular rna mediates pyroptosis of diabetic cardiomyopathy by functioning as a competing endogenous rna. Mol Ther Nucleic Acids. 2019;17:636–43.CrossRef

77.

Bazan HA, Hatfield SA, Brug A, Brooks AJ, Lightell DJ Jr, Woods TC. Carotid plaque rupture is accompanied by an increase in the ratio of serum circr-284 to mir-221 levels. Circ-Cardiovasc Genet. 2017;10(4):e001720.CrossRef

78.

Ernst C, Odom DT, Kutter C. The emergence of pirnas against transposon invasion to preserve mammalian genome integrity. Nat Commun. 2017;8(1):1411.CrossRef

79.

Li C, Ma L, Yu B. Circular rna hsa_circ_0003575 regulates oxldl induced vascular endothelial cells proliferation and angiogenesis. Biomed Pharmacother. 2017;95:1514–9.CrossRef

80.

Kang S, Sohn E, Lee S. Hydrogen sulfide as a potential alternative for the treatment of myocardial fibrosis. Oxid Med Cell Longev. 2020;2020:4105382.CrossRef

81.

Tang C, Zhang M, Huang L, Hu Z, Zhu J, Xiao Z, et al. Circrna_000203 enhances the expression of fibrosis-associated genes by derepressing targets of mir-26b-5p, col1a2 and ctgf, in cardiac fibroblasts. Sci Rep. 2017;7:40342.CrossRef

82.

Zhu Y, Pan W, Yang T, Meng X, Jiang Z, Tao L, et al. Upregulation of circular rna circnfib attenuates cardiac fibrosis by sponging mir-433. Front Genet. 2019;10:564. CrossRef

83.

Ni H, Li W, Zhuge Y, Xu S, Wang Y, Chen Y, et al. Inhibition of circhipk3 prevents angiotensin ii-induced cardiac fibrosis by sponging mir-29b-3p. Int J Cardiol. 2019;292:188–96. CrossRef

84.

Wang K, Dong Y, Liu J, Qian L, Wang T, Gao X, et al. Effects of redox in regulating and treatment of metabolic and inflammatory cardiovascular diseases. Oxid Med Cell Longev. 2020;2020:5860356.CrossRef

85.

Costa M, Cortez-Dias N, Gabriel A, de Sousa J, Fiúza M, Gallego J, et al. Circrna-mirna cross-talk in the transition from paroxysmal to permanent atrial fibrillation. Int J Cardiol. 2019;290:134–7.CrossRef

86.

Jiang S, Guo C, Zhang W, Che W, Zhang J, Zhuang S, et al. The integrative regulatory network of circrna, microrna, and mrna in atrial fibrillation. Front Genet. 2019;10:526.CrossRef

87.

Hu X, Chen L, Wu S, Xu K, Jiang W, Qin M, et al. Integrative analysis reveals key circular rna in atrial fibrillation. Front Genet. 2019;10:108.CrossRef

88.

Liu T, Zhang G, Wang Y, Rao M, Zhang Y, Guo A, et al. Identification of circular rna-microrna-messenger rna regulatory network in atrial fibrillation by integrated analysis. Biomed Res Int. 2020;2020:8037273.

89.

Zhang P, Sun J, Li W. Genome-wide profiling reveals atrial fibrillation-related circular rnas in atrial appendages. Gene. 2020;728:144286.CrossRef

90.

Huang Y, Tang C, Du J, Jin H. Endogenous sulfur dioxide: a new member of gasotransmitter family in the cardiovascular system. Oxid Med Cell Longev. 2016;2016:8961951.CrossRef

91.

Heagerty A, Heerkens E, Izzard A. Small artery structure and function in hypertension. J Cell Mol Med. 2010;14(5):1037–43.

92.

Yin L, Yao J, Deng G, Wang X, Cai W, Shen J. Identification of candidate lncrnas and circrnas regulating wnt3/β-catenin signaling in essential hypertension. Aging. 2020;12(9):8261–88.CrossRef

93.

Wu N, Jin L, Cai J. Profiling and bioinformatics analyses reveal differential circular rna expression in hypertensive patients. Clin Exp Hypertens. 2017;39(5):454–9.CrossRef

94.

Bao X, He X, Zheng S, Sun J, Luo Y, Tan R, et al. Up-regulation of circular rna hsa_circ_0037909 promotes essential hypertension. J Clin Lab Anal. 2019;33(4):e22853.CrossRef

95.

Liu L, Gu T, Bao X, Zheng S, Zhao J, Zhang L. Microarray profiling of circular rna identifies hsa_circ_0126991 as a potential risk factor for essential hypertension. Cytogenet Genome Res. 2019;157(4):203–12.CrossRef

96.

Prestes P, Maier M, Woods B, Charchar F. A guide to the short, long and circular rnas in hypertension and cardiovascular disease. Int J Mol Sci. 2020;21(10):3666.CrossRef

97.

Wang J, Sun H, Zhou Y, Huang K, Que J, Peng Y, et al. Circular rna microarray expression profile in 3,4-benzopyrene/angiotensin ii-induced abdominal aortic aneurysm in mice. J Cell Biochem. 2019;120(6):10484–94.CrossRef

98.

Wilmink A, Quick C. Epidemiology and potential for prevention of abdominal aortic aneurysm. Br J Surg. 1998;85(2):155–62.CrossRef

99.

Golledge J, Moxon J, Singh T, Bown M, Mani K, Wanhainen A. Lack of an effective drug therapy for abdominal aortic aneurysm. J Intern Med. 2020;288(1):6–22.CrossRef

100.

Yang R, Wang Z, Meng G, Hua L. Circular rna ccdc66 facilitates abdominal aortic aneurysm through the overexpression of ccdc66. Cell Biochem Funct. 2020;38(7):830–8.CrossRef

101.

Yue J, Zhu T, Yang J, Si Y, Xu X, Fang Y, et al. Circcbfb-mediated mir-28–5p facilitates abdominal aortic aneurysm via lypd3 and gria4. Life Sci. 2020;253:117533.CrossRef

102.

Zheng C, Niu H, Li M, Zhang H, Yang Z, Tian L, et al. Cyclic rna hsa-circ-000595 regulates apoptosis of aortic smooth muscle cells. Mol Med Rep. 2015;12(5):6656–62.CrossRef

103.

Chen J, Cui L, Yuan J, Zhang Y, Sang H. Circular rna wdr77 target fgf-2 to regulate vascular smooth muscle cells proliferation and migration by sponging mir-124. Biochem Biophys Res Commun. 2017;494:126–32.CrossRef

104.

Mao Y, Wang J, Guo X, Bi Y, Wang C. Circ-satb2 upregulates stim1 expression and regulates vascular smooth muscle cell proliferation and differentiation through mir-939. Biochem Biophys Res Commun. 2018;505(1):119–25.CrossRef

105.

Zhou M, Shi Z, Cai L, Li X, Ding Y, Xie T, et al. Circular rna expression profile and its potential regulative role in human abdominal aortic aneurysm. BMC Cardiovasc Disord. 2020;20(1):70.CrossRef

106.

Salgado-Somoza A, Zhang L, Vausort M, Devaux Y. The circular rna micra for risk stratification after myocardial infarction. Int J Cardiol Heart Vasc. 2017;17:33–6.

107.

Vausort M, Salgado-Somoza A, Zhang L, Leszek P, Devaux Y. Myocardial infarction-associated circular rna predicting left ventricular dysfunction. J Am Coll Cardiol. 2016;68(11):1247–8.CrossRef

108.

Zhao Z, Li X, Gao C, Jian D, Hao P, Rao L, et al. Peripheral blood circular rna hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease. Sci Rep. 2017;7:39918.CrossRef

109.

Yang Y, Yu T, Jiang S, Zhang Y, Li M, Tang N, et al. Mirnas as potential therapeutic targets and diagnostic biomarkers for cardiovascular disease with a particular focus on wo2010091204. Expert Opin Ther Pat. 2017;27(9):1021–9.CrossRef

110.

Bao X, Zheng S, Mao S, Gu T, Liu S, Sun J, et al. A potential risk factor of essential hypertension in case-control study: circular rna hsa_circ_0037911. Biochem Biophys Res Commun. 2018;498(4):789–94.CrossRef

111.

Garikipati V, Verma S, Cheng Z, Liang D, Truongcao M, Cimini M, et al. Circular rna circfndc3b modulates cardiac repair after myocardial infarction via fus/vegf-a axis. Nat Commun. 2019;10(1):4317.CrossRef

112.

Shen L, Hu Y, Lou J, Yin S, Wang W, Wang Y, et al. Circrna-0044073 is upregulated in atherosclerosis and increases the proliferation and invasion of cells by targeting mir-107. Mol Med Rep. 2019;19(5):3923–32.

113.

Yang L, Yang F, Zhao H, Wang M, Zhang Y. Circular rna circchfr facilitates the proliferation and migration of vascular smooth muscle via mir-370/foxo1/cyclin d1 pathway. Mol Ther Nucleic Acids. 2019;16:434–41.CrossRef

114.

Zhang Y, Chen Y, Yao H, Lie Z, Chen G, Tan H, et al. Elevated serum circ_0068481 levels as a potential diagnostic and prognostic indicator in idiopathic pulmonary arterial hypertension. Pulm Circ. 2019;9(4):2045894019888416.CrossRef

115.

Zheng S, Gu T, Bao X, Sun J, Zhao J, Zhang T, et al. Circular rna hsa_circ_0014243 may serve as a diagnostic biomarker for essential hypertension. Exp Ther Med. 2019;17(3):1728–36.

116.

Liu Y, Yang Y, Wang Z, Fu X, Chu X, Li Y, et al. Insights into the regulatory role of circrna in angiogenesis and clinical implications. Atherosclerosis. 2020;298:14–26.CrossRef

117.

Fan X, Weng X, Zhao Y, Chen W, Gan T, Xu D. Circular rnas in cardiovascular disease: an overview. Biomed Res Int. 2017;2017:5135781.CrossRef

118.

Odqvist M, Andersson P, Tygesen H, Eggers K, Holzmann M. High-sensitivity troponins and outcomes after myocardial infarction. J Am Coll Cardiol. 2018;71(23):2616–24.CrossRef

119.

McDonald K, Troughton R, Dahlström U, Dargie H, Krum H, van der Meer P, et al. Daily home bnp monitoring in heart failure for prediction of impending clinical deterioration: results from the home hf study. Eur J Heart Fail. 2018;20(3):474–80.CrossRef

120.

Gaggin H, Januzzi J. Biomarkers and diagnostics in heart failure. Biochem Biophys Acta. 2013;1832(12):2442–50.

121.

Marciniak A, Nawrocka Rutkowska J, Brodowska A, Wiśniewska B, Starczewski A. Cardiovascular system diseases in patients with polycystic ovary syndrome - the role of inflammation process in this pathology and possibility of early diagnosis and prevention. Ann Agric Environ Med. 2016;23(4):537–41.CrossRef

122.

Olson J. D-dimer: an overview of hemostasis and fibrinolysis, assays, and clinical applications. Adv Clin Chem. 2015;69:1–46.CrossRef

123.

Shan C, Zhang Y, Hao X, Gao J, Chen X, Wang K. Biogenesis, functions and clinical significance of circrnas in gastric cancer. Mol Cancer. 2019;18(1):136.CrossRef

124.

Boeckel J, Jaé N, Heumüller A, Chen W, Boon R, Stellos K, et al. Identification and characterization of hypoxia-regulated endothelial circular rna. Circ Res. 2015;117(10):884–90.CrossRef

125.

Yang J, Cheng M, Gu B, Wang J, Yan S, Xu D. Circrna_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via mir-6089/akt1/nf-κb axis. Cell Death Dis. 2020;11(10):833.CrossRef

126.

Fan CY, Lei XJ, Fang ZQ, Jiang QH, Wu FX. Circr2disease: a manually curated database for experimentally supported circular rnas associated with various diseases. Database (Oxford). 2018;2018:bay044.

127.

Yang Q, Du WW, Wu N, Yang W, Awan FM, Fang L, et al. A circular rna promotes tumorigenesis by inducing c-myc nuclear translocation. Cell Death Differ. 2018;24(9):1609–20.CrossRef

128.

Xia S, Feng J, Lei L, Hu J, Xia L, Wang J, et al. Comprehensive characterization of tissue-specific circular rnas in the human and mouse genomes. Brief Bioinform. 2017;18(6):984–92.

129.

Li S, Li Y, Chen B, Zhao J, Yu S, Tang Y, et al. Exorbase: a database of circrna, lncrna and mrna in human blood exosomes. Nucleic Acids Res. 2018;46(D1):D106–12.CrossRef

130.

Tang Z, Li ZX, Zhao J, Qian F, Feng C, Li Y, et al. Trcirc: a resource for transcriptional regulation information of circrnas. Brief Bioinform. 2019;20(6):2327–33.CrossRef

131.

Meng XW, Hu DH, Zhang PJ, Chen Q, Chen M. Circfunbase: a database for functional circular rnas. Database (Oxford). 2019;2019:6.

132.

Dudekula DB, Panda AC, Grammatikakis I, De S, Abdelmohsen K, Gorospe M. Circinteractome: a web tool for exploring circular rnas and their interacting proteins and micrornas. RNA Biol. 2016;13(1):34–42.CrossRef

133.

Zhao S, Li S, Liu W, Wang Y, Li X, Zhu S, et al. Circular rna signature in lung adenocarcinoma: a mioncocirc database-based study and literature review. Front Oncol. 2020;10:523342.CrossRef

134.

Ghosal S, Das S, Sen R, Basak P, Chakrabarti J. Circ2traits: a comprehensive database for circular rna potentially associated with disease and traits. Front Genet. 2013;4:283.CrossRef

135.

Wu S, Liu H, Huang P, Chang I, Lee C, Yang C, et al. Circlncrnanet: an integrated web-based resource for mapping functional networks of long or circular forms of noncoding rnas. GigaScience. 2018;7(1):1–10.

136.

Liu M, Wang Q, Shen J, Yang BB, Ding X. Circbank: a comprehensive database for circrna with standard nomenclature. RNA Biol. 2019;16(7):899–905. CrossRef

137.

Liu YC, Li JR, Sun CH, Andrews E, Chao RF, Lin FM, et al. Circnet: a database of circular rnas derived from transcriptome sequencing data. Nucleic Acids Res. 2016;44(D1):D209–15.CrossRef

138.

Wu W, Ji P, Zhao F. Circatlas: An integrated resource of one million highly accurate circular rnas from 1070 vertebrate transcriptomes. Genome Biol. 2020;21(1):101.CrossRef

139.

Zheng L, Li J, Wu J, Sun W, Liu S, Wang Z, et al. Deepbase v2.0: identification, expression, evolution and function of small rnas, lncrnas and circular rnas from deep-sequencing data. Nucleic Acids Res. 2016;44(D1):D196-202.CrossRef

140.

Zhong S, Wang J, Zhang Q, Xu H, Feng J. Circprimer: a software for annotating circrnas and determining the specificity of circrna primers. BMC Bioinformatics. 2018;19(1):292.CrossRef

141.

Dong R, Ma X, Li G, Yang L. Circpedia v2: an updated database for comprehensive circular rna annotation and expression comparison. Genomics Proteomics Bioinformatics. 2018;16(4):226–33.CrossRef

Titel: The Function and Therapeutic Potential of Circular RNA in Cardiovascular Diseases
verfasst von: Kai Wang
Xiang-Qian Gao
Tao Wang
Lu-Yu Zhou
Publikationsdatum: 16.07.2021
Verlag: Springer US
Erschienen in: Cardiovascular Drugs and Therapy / Ausgabe 1/2023
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI: https://doi.org/10.1007/s10557-021-07228-5

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