Background
Renal support in 2027: addressing CRRT’s current limitations
Adoption of precision CRRT
Dosing of CRRT
Timing of CRRT initiation
Management of fluid overload
Antibiotic dosing during CRRT
• Estimation of pharmacokinetic parameters, including variability | |
• Comparison of pharmacokinetic parameters with those of typical patients with normal kidney function (literature or sponsor data) or the appropriate reference population | |
• Quantification of the impact of changes in the prescribed Q
e
on the pharmacokinetic parameters of interest, and interpolation for flow rates not evaluated in this study | |
• Assessment of whether dosage adjustment is warranted in CRRT recipients | |
• If dosage adjustment is warranted, derivation of specific dosing recommendations for the studied conditions |
Anticoagulation
Quality metrics
Theme | Measures |
---|---|
Dose prescription | High vs low dose |
Dose delivery | Percentage of prescribed dose delivered |
Anticoagulation selection | Heparin vs citrate vs none |
Anticoagulation monitoring | PTT monitoring, citrate monitoring |
Anticoagulation complications | Bleeding, hypocalcemia, incidence of HIT |
Treatment interruption | Number of interruptions and duration of interruptions; time to establish new circuit |
Catheter-related issues | Infections, bleeding, obstruction/thrombosis |
Circuit-related issues | Hiter clotting, pressure alarming |