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Erschienen in: Current Oral Health Reports 1/2020

14.01.2020 | Host Parasite Interactions in Periodontal Disease (C Genco and D Kinane, Section Editors)

The Gastrointestinal Microbiome in Chronic Renal Diseases

verfasst von: Mark A. Bryniarski, Sarah E. M. Hoffman, Rabi Yacoub

Erschienen in: Current Oral Health Reports | Ausgabe 1/2020

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Abstract

Purpose of Review

The relationship between microorganisms within the gastrointestinal tract and the renal function of the host is reciprocal. The objective of the current review is therefore twofold. First, we aim to demonstrate the emerging role of gastrointestinal microbiome dysbiosis in the pathogenesis and progression of chronic kidney disease. Second, we highlight specific mechanisms as to how microbiome dysbiosis is provoked in chronic kidney disease.

Recent Findings

Current work has shown that microbiome dysbiosis can directly and indirectly influence renal physiology and contribute to the onset and development of chronic kidney disease, such as by stimulating hypertension. It is also becoming evident that the composition and function of both the intestinal and oral microbiomes are adversely impacted by chronic kidney disease, which can further exacerbate dysbiosis.

Summary

This review discusses the current knowledge on the associations between the gastrointestinal microbiome and renal health, to which Dr. Robert Genco has contributed substantially. As we mourn his loss, we celebrate his lifelong dedication to the advancement of research at the University at Buffalo and the microbiome research community worldwide.
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Metadaten
Titel
The Gastrointestinal Microbiome in Chronic Renal Diseases
verfasst von
Mark A. Bryniarski
Sarah E. M. Hoffman
Rabi Yacoub
Publikationsdatum
14.01.2020
Verlag
Springer International Publishing
Erschienen in
Current Oral Health Reports / Ausgabe 1/2020
Elektronische ISSN: 2196-3002
DOI
https://doi.org/10.1007/s40496-020-00258-2

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