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Inflammation Research
Erschienen in: Inflammation Research 2/2018

03.11.2017 | Commentary

The gestational power of mast cells in the injured tissue

verfasst von: Maria-Angeles Aller, Natalia Arias, Vicente Martínez, Patri Vergara, Jaime Arias

Erschienen in: Inflammation Research | Ausgabe 2/2018

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Abstract

The inflammatory response expressed after wound healing would be the recapitulation of systemic extra-embryonic functions, which would focus on the interstitium of the injured tissue. In the injured tissue, mast cells, provided for a great functional heterogeneity, could play the leading role in the re-expression of extra-embryonic functions, i.e., coelomic–amniotic and trophoblastic–vitelline. Moreover, mast cells would favor the production of a gastrulation-like process, which in certain tissues and organs would induce the regeneration of the injured tissue. Therefore, the engraftment of mesenchymal stem cells and mast cells, both with an extra-embryonic regenerative phenotype, would achieve a blastema, from the repaired and regenerated injured tissue, rather than by fibrosis, which is commonly made through wound-healing.
Literatur
1.
2.
Harper D, Young A, McNaught CE. The physiology of wound healing. Surgery (Oxford) 2014;32:445–50.CrossRef
3.
Portou MJ, Baker D, Abraham D, Tsui J. The innate immune system, toll-like receptors and dermal wound healing: a review. Vascul Pharmacol. 2015;71:31–6.CrossRefPubMed
4.
Aller MA, Arias JI, Arraez-Aybar LA, Gilsanz C, Arias J. Wound healing reaction: a switch from gestation to senescence. World J Exp Med. 2014;4:16–26.CrossRefPubMedPubMedCentral
5.
Childs DR, Murthy AS. Overview of wound healing and management. Surg Clin N Am. 2017;97:189–207.CrossRefPubMed
6.
Frykberg RG, Banks J. Challenges in the treatment of chronic wounds. Adv Wound Care. 2015;4(9):560–76.CrossRef
7.
Sorci G, Faivre B. Inflammation and oxidative stress in vertebrate host–parasite systems. Philos Trans R Soc Lond B Biol Sci. 2009;364:71–83.CrossRefPubMed
8.
9.
Nathan C. Points of control in inflammation. Nature 2002;420:848–52.CrossRef
10.
Libby P. Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr Rev. 2007;65(12Pt2):S140–6.CrossRefPubMed
11.
12.
13.
Straub RH, Schradin C. Chronic inflammatory systemic diseases. An evolutionary trade-off between acutely beneficial but chronically harmful programs. Evol Med Public Health. 2016;2016:37–51.PubMedPubMedCentral
14.
Bangi E. Drosophila at the intersection of infection, inflammation and cancer. Front Cell Infect Microbiol. 2013;3:1–6.CrossRef
15.
Wang L, Kounatidis I, Ligoxygakis P. Drosophila as a model to study the role of blood cells in inflammation, innate immunity and cancer. Front Cell Infect Microbiol. 2014;3:1–17.CrossRef
16.
17.
Campos-Ramos G. Inflammation as an animal development phenomenon. Clin Dev Immunol. 2012;2012:983203.
18.
Aller MA, Arias N, Fuentes-Julian S, Blazquez-Martinez A, Argudo S, De Miguel MP, Arias JL, Arias J. Coupling inflammation with evo-devo. Med Hypotheses. 2012;78:721–31.CrossRefPubMed
19.
Aller MA, Arias JI, Prieto J, Gilsanz C, Arias A, Yang H, Arias J. Surgical inflammatory stress: the embryo takes hold of the reins again. Theor Biol Med Model. 2013;10:6.CrossRefPubMedPubMedCentral
20.
Moon TC, Befus AD, Kulka M. Mast cell mediators: their differential release and the secretory pathways involved. Front Immunol. 2014;5:1–18.CrossRef
21.
Krystel-Whittemore M, Dileepan KN, Wood JG. Mast cell: a multi-functional master cell. Front Immunol. 2016;6:1–12.CrossRef
22.
Arodz T, Bonchev D, Diegelmann RF. A network approach to wound healing. Adv Wound Care. 2013;2:499–509.CrossRef
23.
Kalkhof S, Förster Y, Schmidt J, Schulz MC, Baumann S, Weibflog A, Gao W, Hempel U, Eckelt U, Rammelt S, Von Bergen M. Proteomics and metabolomics for in situ monitoring of wound healing. Bio Med Res Int. 2014;2014:1–12.CrossRef
24.
Takemoto CM, Lee Y-N, Jegga AG, Zablocki D, Brandal S, Shahlaee A, Huang S, Ye Y, Gowrisankar S, Huynh J, McDevitt MA. Mast cell transcriptional networks. Blood Cells Mol Dis. 2008;41:82–90.CrossRefPubMedPubMedCentral
25.
Clark RAF. Basics of cutaneous wound repair. J Demartol Surg Oncol. 1993;19:693–706.CrossRef
26.
Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanism. J Invest Dermatol. 2007;127:514–25.CrossRefPubMed
27.
28.
29.
Rose LF, Chan RK. The burn wound microenviroment. Adv Wound Care 2016;5:106–12.CrossRef
30.
Aller MA, Arias JI, Nava MP, Arias J. Post-traumatic inflammation is a complex response based in the pathological expression of the nervous, immune and endocrine functional systems. Exp Biol Med 2004;229:170–81.CrossRef
31.
Rohen JW, Lütjen-Drecoll E. Funktionelle embryologie Schattauer GmbH. Stuttgart Germany 2006;1–162.
32.
Crivellato E, Ribatti D. The mast cell: an evolutionary perspective. Biol Rev 2010;85:347–60.CrossRefPubMed
33.
Singh J, Shah R, Singh D. Targeting mast cells: uncovering prolific therapeutic role in myriad diseases. Int Immunopharmacol. 2016;40:362–84.CrossRefPubMed
34.
Wernersson S, Pejler G. Mast cell secretory granules: armed for battle. Nature Rev Immunol. 2014;14:478–94.CrossRef
35.
Aller MA, Arias JI, Prieto I, Gilsanz C, Arias JL, Yang H, Arias J. Phases of the acute inflammatory response to the injury. In: Arias J, Aller MA, Arias JI, editors. Surgical inflammation, chap. 4. USA: Bentham Science; 2013. pp. 99–128.CrossRef
36.
Aller MA, Arias JI, Giner M, Losada M, Cruz A, Alonso-Pozas A, Arias J. Oxygen-related inflammatory wound phenotypes. In: Middleton JE, editors. Wound healing: process, phases and promoting, Chap. 2. Huntington: Nova Sciences; 2011. pp. 1–26.
37.
Uberti MG, Pierpont YN, Ko F, Wright TE, Smith CA, Cruse CW, Robson MC, Payne WG. Amnion-derived cellular cytokine solution (ACCS) promotes migration of keratinocytes and fibroblasts. Ann Plast Surg. 2010;64:632–5.PubMed
38.
Dovaiher J, Succar J, Lancerotto L, Gurish MF, Orgill DP, Hamilton MJ, Krillis SA, Stevens RL. Development of mast cells and importance of their tryphase and chymasa serine proteases in inflammation and wound healing. Adv Immunol. 2014;122:211–52.CrossRef
39.
Wong VW, Gurtner CG, Longaker MT. Woung healing: a paradigm for regeneration. Mayo Clin Proc. 2013;88:1022–31.CrossRefPubMed
40.
Aller MA, Blanco-Rivero J, Arias JI, Balfagon G, Arias J. The wound-healing response and upregulated embryonic mechanisms: brothers-in-arms forever. Exper Dermatol. 2012;21:497–503.CrossRef
41.
Ehninger A, Trumpp A. The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move. Int J Exp Med. 2011;208:421–8.CrossRef
42.
Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340:448–54.CrossRefPubMed
43.
Siegel N, Rosner M, Hanneder M, Freilinger A, Hengstschläger M. Human amniotic fluid stem cells: a new perspective. Amino Acids. 2008;35:291–3.CrossRefPubMed
44.
Fraser ST, Baron MH. Embryonic fates for extraembryonic lineages: new perspectives. J Cell Biochem. 2009;107:586–91.CrossRefPubMed
45.
Ueno H, Weisman IL. The origin and fate of yolk sac hematopoiesis: application of chimera analysis to developmental studies. Int J Dev Biol. 2010;54:1019–31.CrossRefPubMed
46.
Antonucci I, Provenzano M, Rodrigues M, Pantalone A, Salini V, Ballerini P, Borlongan CV, Stuppia L. Amniotic fluid stem cells: a novel source for modeling of human genetic diseases. Int J Mol Sci. 2016;17:E607.CrossRefPubMed
47.
48.
Nurden AT. Platelets, inflammation and tissue regeneration. Tromb Haemost. 2011;105(Suppl 1):S13–33.CrossRef
49.
Yoshida S, Wada Y. Transfer of maternal cholesterol to embryo and fetus in pregnant mice. J Lipid Res. 2005;46:2168–74.CrossRefPubMed
50.
Miller WL, Bose HS. Early steps in steroidogenesis: Intracellular cholesterol trafficking. J Lipid Res. 2011;5:2111–35.CrossRef
51.
Gilliver SC. Sex steroids as inflammatory regulators. J Steroid Biochem Mol Biol. 2010;120:105–15.CrossRefPubMed
52.
53.
Melo RCN, D’Avila H, Wan H-C, Bozza PT, Dvorak AM, Weller PF. Lipid bodies in inflammatory cells: structure, function and current imaging techniques. J Histochem Cytochem. 2011;59:540–6.CrossRefPubMedPubMedCentral
54.
Ghesquiere B, Wong BW, Kuchnio A, Carmeliet P. Metabolism of stromal and immune cells in health and disease. Nature 2014;511:167–76.CrossRefPubMed
55.
56.
57.
Csaba G. Mast cell, the peculiar member of the immune system: a homeostatic aspect. Acta Microbiol Immunol Hung. 2015;63:207–31.CrossRef
58.
Yokoyama H. Initiation of limb regeneration: the critical step for regenerative capacity. Dev Growth Differ. 2008;50:13–22.CrossRefPubMed
59.
Khodadi E, Shahrabi S, Shahjahani M, Azandeh S, Saki N. Role of stem cell factor in the placental niche. Cell Tissue Res. 2016;366:523–31.CrossRefPubMed
60.
Balaji S, Watson CL, Ranjan R, King A, Bollyky PL, Keswani SG. Chemokine involvement in fetal and adult wound healing. Adv Wound Care. 2015;4:660–71.CrossRef
61.
Latchana N, Peck JR, Whitson B, Black SM. Preservation solutions for cardiac and pulmonary donor grafts: a review of the current literature. J Thorac Dis. 2014;6:1143–9.PubMedPubMedCentral
62.
Latchana N, Peck JR, Whitson BA, Henry ML, Elkhammas EA, Black SM. Preservation solutions used during abdominal transplantation: current status and outcomes. World J Transpl. 2015;5:154–64.CrossRef
63.
Nazari M, Ni NC, Lüdke A, Li SH, Guo J, Weisel RD, Li RK. Mast cell promote proliferation and migration and inhibit differentiation of mesenchymal stem cells through PDGF. J Mol Cell Cardiol. 2016;94:32–42.CrossRefPubMed
64.
Wulff BC, Parent AE, Meleski MA, DiPietro LA, Schrementi ME, Wilgus TA. Mast cells contribute to scar formation during fetal wound healing. J Invest Dermatol. 2012;132:458–65.CrossRefPubMed
65.
Wilgus TA, Wulff BC. The importance of mast cells in dermal scarring. Adv Wound Care. 2014;3:356–65.CrossRef
66.
Douaiher J, Succar J, Lancerotto L, Gurish MF, Orgill DP, Hamilton MJ, Krilis SA, Stevens RL. Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing. Adv Immunol. 2014;122:211–52.CrossRefPubMedPubMedCentral
67.
Sriram G, Bigliardi PL, Bigliardi-Qi M. Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro. Eur J Cell Biology. 2015;94:483–512.CrossRef
68.
Flor J. Salamander regeneration as a model for developing novel regenerative and anticancer therapies. J Cancer. 2014;5:715–9.CrossRef
69.
Redd MJ, Cooper L, Wood W, Stramer B, Martin P. Wound healing and inflammation: embryos reveal the way to perfect repair. Phil Trans R Soc Lond B. 2004;339:777–84.CrossRef
70.
Motegi S-I, Ishikawa O. Mesenchymal stem cells: The roles and functions in cutaneous wound healing and tumor growth. J Dermatol Sci. 2016;1811:30721–6.
71.
Otero-Viñas M, Falanga V. Mesenchymal stem cells in chronic wounds: the spectrum from basic to advanced therapy. Adv Wound Care. 2016;5:149–63.CrossRef
72.
Theoharides TC, Kempuraj D, Tagen M, Vasiadi M, Centrulo CL. Human umbilical cord blood-derived mast cells. A unique model for the study of neuro-immuno-endocrine interactions. Stem Cell Rev. 2006;6:143–54.
Metadaten
Titel
The gestational power of mast cells in the injured tissue
verfasst von
Maria-Angeles Aller
Natalia Arias
Vicente Martínez
Patri Vergara
Jaime Arias
Publikationsdatum
03.11.2017
Verlag
Springer International Publishing
Erschienen in
Inflammation Research / Ausgabe 2/2018
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-017-1108-5

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