Skip to main content

01.06.2014 | Gynecologic Endocrinology and Reproductive Medicine | Ausgabe 6/2014

Archives of Gynecology and Obstetrics 6/2014

The hysteroscopy and histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients

Archives of Gynecology and Obstetrics > Ausgabe 6/2014
Rui Yang, Xiaoguo Du, Ying Wang, Xueling Song, Yan Yang, Jie Qiao
Wichtige Hinweise
R. Yang and X. Du were joint first authors of this article.


To study the consistency of hysteroscopy findings and histological chronic endometritis (CE) in recurrent implantation failure (RIF) cases, and to compare their values in indicating antibiotic treatment.


Sixty RIF cases (January 2009–January 2010) and 202 consecutive RIF cases (May 2010–April 2012) in Peking University Third Hospital reproductive medical center were studied. 60 RIF patients’ endometrial samples redid section and CD38/CD138 immunohistochemical stain for CE screening. In 202 RIF cases, the presence of hyperemia, mucosal edema, and micropolyps under hysteroscopy were considered CE diagnostic parameters. Antibiotic was offered to part of the patients. The patients’ clinical outcomes were analyzed by statistical methods.


In 202 RIF cases, the hysteroscopy CE rate was 66.3 %, while histological CE rate was 43.6 %. The sensitivity and specificity of hysteroscopy were 35.2 and 67.5 %. In histological CE patients, 68 cases underwent regular antibiotic treatment and 20 did not. Two groups had similar clinical pregnancy rates (35.3 vs. 30.0 %), embryo implantation rates (18.9 vs. 20.4 %) and ongoing pregnancy rates (29.4 vs. 25.0 %). In hysteroscopy CE patients, the implantation rate (18.6 vs. 4.9 %) and ongoing pregnancy rate (29.3 vs. 7.4 %) significantly increased (P < 0.05) with antibiotic treatment, and higher intrauterine pregnancy rate in treatment group (29.3 vs. 11.1 %). In reviewing the chosen 60 RIF cases, the histological CE rates were similar in both pregnancy and non-pregnancy group after subsequent embryo transfer.


CE occurs frequently in RIF patients; hysteroscopy has more diagnostic and treatment value for them.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf

Weitere Produktempfehlungen anzeigen
Über diesen Artikel

Weitere Artikel der Ausgabe 6/2014

Archives of Gynecology and Obstetrics 6/2014 Zur Ausgabe

Gynecologic Endocrinology and Reproductive Medicine

Hormonal and functional biomarkers in ovarian response

  1. Sie können e.Med Gynäkologie & Urologie 14 Tage kostenlos testen (keine Print-Zeitschrift enthalten). Der Test läuft automatisch und formlos aus. Es kann nur einmal getestet werden.

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Gynäkologie und bleiben Sie gut informiert – ganz bequem per eMail.