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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 2/2015

01.04.2015 | Skeletal Development (E Schanipani and E Zelzer, Section Editors)

The Immunological Contribution to Heterotopic Ossification Disorders

verfasst von: Michael R. Convente, Haitao Wang, Robert J. Pignolo, Frederick S. Kaplan, Eileen M. Shore

Erschienen in: Current Osteoporosis Reports | Ausgabe 2/2015

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Abstract

The formation of bone outside the endogenous skeleton is a significant clinical event, rendering affected individuals with immobility and a diminished quality of life. This bone, termed heterotopic ossification (HO), can appear in patients following invasive surgeries and traumatic injuries, as well as progressively manifest in several congenital disorders. A unifying feature of both genetic and nongenetic episodes of HO is immune system involvement at the early stages of disease. Activation of the immune system sets the stage for the downstream anabolic events that eventually result in ectopic bone formation, rendering the immune system a particularly appealing site of early therapeutic intervention for optimal management of disease. In this review, we will discuss the immunological contributions to HO disorders, with specific focus on contributing cell types, signaling pathways, relevant in vivo animal models, and potential therapeutic targets.
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Metadaten
Titel
The Immunological Contribution to Heterotopic Ossification Disorders
verfasst von
Michael R. Convente
Haitao Wang
Robert J. Pignolo
Frederick S. Kaplan
Eileen M. Shore
Publikationsdatum
01.04.2015
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 2/2015
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-015-0258-z

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