Background
Methods
Setting
Patients
Baseline measurements
Clinical measurements
Questionnaires
Interventions and treatment targets
Outcomes and data collection
Statistical analyses
Results
Baseline characteristics
Characteristics | Measures |
---|---|
Female, n (%) | 70 (63) |
Age, years, mean (SD) | 59 (10) |
Higher education, n (%) | 28 (25) |
Married or co-habiting, n (%) | 86 (77) |
Working, n (%) | 53 (48) |
BMI, kg/m2, mean (SD) | 29.3 (4.8) |
Physical activity (FIT-index), mean (SD) | 37 (19) |
Diabetes mellitus, n (%) | 9 (8) |
Insulin treatment, n (%) | 2 (2) |
Lipid lowering medication, n (%) | 22 (20) |
Any continuous medication other than diabetes, n(%) | 47 (42) |
Smoking, n (%) | 20 (18) |
eGFR < 60 ml/min/1,73m2, n (%) | 5 (5) |
Proteinuria, n (%) | 1 (1) |
10-year SCORE risk, n (%) | |
Low | 21 (20) |
Moderate | 66 (62) |
High | 17 (16) |
Very high | 2 (2) |
Outcomes
Outcome | At baseline mean (SD) | Change at 12 months mean (95% CI) | P-value |
---|---|---|---|
Office SBP, mmHg | 173 (20) | − 22 (− 27 to − 18) | < 0.001 |
Office DBP, mmHg | 102 (12) | − 13 (− 15 to − 10) | < 0.001 |
Home SBP, mmHg | 153 (13) | − 15 (− 18 to − 11) | < 0.001 |
Home DBP, mmHg | 92 (7) | − 10 (− 12 to − 8) | < 0.001 |
EQ-5D | 0.872 (0.153) | − 0.045 (− 0.076 to − 0.015) | 0.004 |
EQ-5D VAS | 77 (14) | 1 (− 1 to 3) | 0.32 |
Weight, kg | 84.1 (17.2) | 0.0 (0.7 to 0.7) | 0.94 |
Waist circumference, cm | 101 (16) | − 1 (− 3 to 1) | 0.21 |
Total cholesterol, mmol/l | 5.36 (1.11) | − 0.37 (− 0.56 to − 0.19) | < 0.001 |
LDL cholesterol, mmol/l | 3.15 (1.01) | − 0.32 (− 0.51 to − 0.13) | < 0.001 |
HDL cholesterol, mmol/l | 1.61 (0.45) | − 0.04 (− 0.08 to 0.01) | 0.069 |
Triglycerides, mmol/l | 1.37 (0.98) | − 0.01 (− 0.13 to 0.10) | 0.82 |
Fasting glucose, mmol/l | 5.87(0.85) | − 0.07 (− 0.23 to 0.10) | 0.40 |
Alcohol use, AUDIT-C score | 3.3 (2.6) | − 0.2 (− 0.5 to − 0.0) | 0.048 |
Physical activity, FIT index | 38 (19) | 2 (–1 to 5) | 0.10 |
Outcome | r (95% CI) | |
---|---|---|
Crude | Adjusted* | |
Weight, kg | 0.08 (− 0.11 to 0.27) | 0.06 (− 0.13 to 0.25) |
Waist, cm | − 0.07 (− 0.25 to 0.13) | − 0.13 (− 0.32 to 0.06) |
Physical activity, FIT index | 0.05 (− 0.14 to 0.23) | 0.08 (− 0.11 to 0.26) |
AUDIT-C score | 0.02 (− 0.17 to 0.21) | − 0.01 (− 0.20 to 0.18) |
Total cholesterol, mmol/l | − 0.05 (− 0.24 to 0.15) | 0.01 (− 0.18 to 0.21) |
LDL cholesterol, mmol/l | − 0.05 (− 0.25 to 0.15) | 0.01 (− 0.19 to 0.21) |
HDL cholesterol, mmol/l | 0.10 (− 0.10 to 0.29) | 0.16 (− 0.04 to 0.35) |
Triglycerides, mmol/l | − 0.03 (− 0.23 to 0.17) | − 0.07 (− 0.27 to 0.13) |
Fasting glucose, mmol/l | − 0.09 (− 0.29 to 0.11) | − 0.12 (− 0.31 to 0.08) |
Office BP, mmHg | ||
SBP | − 0.13 (− 0.32 to 0.06) | − 0.02 (− 0.21 to 0.17) |
DBP | − 0.13 (− 0.31 to 0.06) | − 0.11 (− 0.29 to 0.08) |