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05.06.2018 | Brief Communication

The impact of axial spondyloarthritis on quality of life (QoL): a comparison with the impact of moderate to end-stage chronic kidney disease on QoL

Zeitschrift:
Quality of Life Research
Autoren:
Yu Heng Kwan, Warren Fong, Priscilla How, Hwee-Lin Wee, Ying Ying Leung, Jie Kie Phang, Nai Lee Lui, Chuen Seng Tan, Rahul Malhotra, Truls Østbye, Julian Thumboo

Abstract

Purpose

The purpose of the study was to assess the impact of axial spondyloarthritis (axSpA) on patients’ quality of life (QoL) compared to patients with moderate to end-stage chronic kidney disease (CKD).

Methods

We conducted secondary analysis of QoL data obtained from patients with axSpA and CKD from 2011 to 2014. QoL was assessed using the SF-36 version 2 and KDQoL-SF for patients with axSpA and CKD, respectively. Patients with CKD were subcategorized to CKD-pre-dialysis, hemodialysis (CKD-HD) and peritoneal dialysis (CKD-PD). Linear regression was used to compare QoL between patients with axSpA and CKD after adjusting for age, gender, ethnicity, education level, and marital status.

Results

A total of 765 patients (mean age 54.6, 63.0% males, 69.0% Chinese) were analyzed, of which 188 (24.5%) had axSpA. Patients with axSpA had poorer SF-36 bodily pain (BP) scores (axSpA: reference; CKD-pre-dialysis β: 11.04, p < 0.001; CKD-HD β: 9.52, p < 0.001; CKD-PD β: 10.35, p < 0.001) and higher general health scores (axSpA: reference; CKD-pre-dialysis β: − 7.87, p < 0.001; CKD-HD β: − 7.14, p < 0.001, CKD-PD β: − 7.25, p < 0.001) as compared to patients with CKD. Generally, patients with axSpA had poorer SF-36 scores than patients with CKD-pre-dialysis and similar SF-36 scores compared to patients with CKD-HD or CKD-PD.

Conclusions

The burden of axSpA on QoL is not trivial and is comparable to patients with CKD-HD or CKD-PD.

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Zusatzmaterial
Supplementary material 1 (DOCX 28 KB)
11136_2018_1900_MOESM1_ESM.docx
Literatur
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