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29.06.2016 | Original Article | Ausgabe 7/2016

Pediatric Cardiology 7/2016

The Impact of Concomitant Left Ventricular Non-compaction with Congenital Heart Disease on Perioperative Outcomes

Zeitschrift:
Pediatric Cardiology > Ausgabe 7/2016
Autoren:
Preeti Ramachandran, Jessica G. Woo, Thomas D. Ryan, Roosevelt Bryant, Haleh C. Heydarian, John L. Jefferies, Jeffrey A. Towbin, Angela Lorts
Wichtige Hinweise
Dr. Jeffrey A. Towbin and Dr. John L. Jefferies are funded by the NIH-NHLBI Pediatric Cardiomyopathy Registry (PCMR; 2RO1 HL53392-06A1 and 1R01 HL109090-01).

Abstract

Left ventricular non-compaction (LVNC) is a heterogeneous myocardial disorder characterized by prominent trabeculations and inter-trabecular recesses which may occur in association with congenital heart disease (CHD). To date, few studies have been performed to assess whether the concomitant diagnosis of LVNC affects the outcomes of CHD surgery. A retrospective review of patients with LVNC with CHD (LVNC-CHD), 0–5 years of age, was conducted. Patients with CHD without LVNC (CHD-only) and 0–5 years of age with similar diagnosis distribution were selected for comparison. Perioperative data, including CHD diagnosis, operative course, and postoperative complications were collected and compared between groups. LVNC-CHD was diagnosed in 26 children. Of the 26 with LVNC-CHD, 20 underwent surgery and these patients were compared with 276 CHD-only controls. Median total length of stay in the hospital was 12.5 days (IQR 5.5–63 days) in LVNC-CHD compared to 5 days (IQR 3–10 days) in CHD-only (p < 0.005). Postoperative death, cardiac arrest, or need for ECMO or transplantation occurred in 6/20 (30 %) of the LVNC-CHD patients compared to 3/276 (1 %) of the CHD-only group (p < 0.0001). LVNC-CHD patients had significantly longer hospital length of stay and higher perioperative complications compared to CHD-only patients without myocardial abnormalities. Pediatric cardiac care teams should be cognizant of the possibility of the increased perioperative risk associated with concomitant LVNC. Future prospective studies are warranted.

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