The online version of this article (doi:10.1186/1129-2377-15-23) contains supplementary material, which is available to authorized users.
Bulent Turan, Zeynep Osar Siva contributed equally to this work.
The authors declare that they have no competing interests.
BT: Supervised the statistical analyses and interpreted the data; contributed to writing and revising the manuscript. ZOS, DU: Involved in conception and design of the study, acquisition of the data, and writing the manuscript. DK: Organized the laboratory investigations, contributed to writing the laboratory Methods and Results sections. FE: Involved in organizing the patients’ appointments, performed BMI calculations. SS, BG, AS: Were involved in revising the manuscript for important intellectual content, contributed to study conception and design, and acquisition of data. All authors read and approved the final manuscript.
Comorbidity of migraine with anxiety and depression may play a role in the link between migraine and obesity. We examined the moderating and mediating roles of ghrelin in the relationship between depression (and anxiety) and body weight in newly diagnosed migraineurs.
Participants were 63 newly diagnosed migraine patients (using the ICHD-II criteria) and 42 healthy volunteers. Body mass index (BMI) was calculated by measuring height and weight. Ghrelin was assessed at fasting. Depression was assessed with the Hamilton Depression scale, and anxiety with the Hamilton Anxiety scale.
The data did not support the mediating role of ghrelin in the relationship between depression (or anxiety) and BMI for either the migraine or the control group. The interaction between ghrelin and depression as well as anxiety was significant for the migraine group, but not for the control group. Depressed (or anxious) migraineurs had a positive association between ghrelin and BMI, whereas for the non-depressed (or non-anxious) migraineurs this association was negative.
Depression and anxiety moderated the effect of ghrelin on BMI for migraineurs. Management of anxiety and depression might be regarded as part of migraine treatment.
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- The impact of depression and ghrelin on body weight in migraineurs
Zeynep Osar Siva
- Springer Milan
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