Background
Gastric cancer constitutes a major health problem worldwide and is the second most common cause of cancer death [
1]. Surgical resection is the main treatment for gastric cancer. Several studies have pointed out that old and young patients carry potential differences in surgery [
2,
3]. Older gastric-cancer patients who undergo gastrointestinal surgery may encounter more adverse postoperative outcomes than younger patients [
4]. Thus, the need exists to assess the risk of gastrointestinal surgery, especially in older gastric cancer patients.
The prevalence of frailty increases with aging [
5]. Frailty is defined as a clinically recognisable state of older adults with increased vulnerability, resulting from age-associated decline in physiological reserve and function across multiple organ systems [
5,
6]. Frailty assessment may be a very useful tool for preoperative risk assessment in gastric cancer patients. By assessing frailty, patients can be assigned to undergo either a more tailored individual approach or a standard treatment [
5]. Sarcopenia is a syndrome characterised by progressive and generalised loss of skeletal muscle mass and strength [
7] and is an important geriatric syndrome closely related to frailty syndrome [
8‐
10]. Increasing evidence shows that frailty or sarcopenia is related to the risk of adverse postoperative outcomes, including morbidity, institutionalisation, prolonged length of hospitalisation, and mortality [
2,
9,
11]. Therefore, assessment of frailty and sarcopenia is necessary for older gastric-cancer patients potentially undergoing surgery [
5,
12‐
14].
However, studies concerning the benefit of assessing frailty and sarcopenia in older patients with gastric cancer undergoing gastric surgery are scarce, and the conclusions are inconsistent [
2,
9,
11,
15]. Therefore, we conducted this systematic review and meta-analysis aiming to examine the impact of frailty or sarcopenia on postoperative outcomes in older patients undergoing elective gastrectomy surgery.
Methods
Search strategy
We searched the following electronic databases: (1) MEDLINE (Ovid, 1946 to August 24, 2016); (2) EMBASE (Ovid, 1974 to August 24, 2016). We used medical subject headings (MeSH) or equivalent and text word terms for MEDLINE and adaptations of the search strategy for EMBASE. We also searched the PubMed web version on August 24, 2016 (
https://www.ncbi.nlm.nih.gov/pubmed/), and Google website (
www.google.com) for unpublished studies on June 1, 2017. As mentioned in the methodology specified under the PRISMA guidelines (
www.prisma-statement.org), two researchers (YJS and JHZ), in collaboration with a medical librarian, performed a systematic search. The following keywords were used for the search: gastric cancer, aged, frailty, sarcopenia, geriatric assessment, postoperative complications and postoperative outcomes. The search string is included in detail in the Additional file
1. We tailored searches to individual databases. The search was completed on August 24, 2016, and animal restriction was applied. In addition, the reference lists of the selected articles were also reviewed to identify relevant articles.
Study selection
Studies were eligible if they reported postoperative outcomes in older patients with gastric cancer in relation to frailty or sarcopenia profile. We included both retrospective and prospective cohort studies, which described clinical trials in which patients, with an average age of 60 years and older, underwent elective gastric surgery for gastric cancer and were categorised into frail or sarcopenic and non-frail or non-sarcopenic groups. In addition, the criteria used to categorise the patients into frail or sarcopenic groups had to be clearly reported, and frailty or sarcopenia had to be determined in a clinical setting. Studies were excluded if they did not examine postoperative outcomes or surgical complications such as wound infection, anastomotic leakage or mortality as endpoints.
The titles and abstracts of the articles were screened by two investigators (YJS and JHZ). Whenever an article was considered relevant, we reviewed the full text. Finally, to identify potentially eligible studies, we also reviewed all the references in lists of the included studies. We resolved disagreements by discussion to reach a consensus with a third review author (BRD).
Data charting
One reviewer (YJS) extracted the following data from the included studies: first author, study population, study design, sample size, age of the participants (mean age and standard deviation, if reported), year of publication, country and period of enrolment and inclusion and exclusion criteria of the study. Another reviewer (JHZ) independently double-checked this process. We extracted data regarding the targeted endpoints of this review: criteria and prevalence of frailty and sarcopenia and postoperative outcomes in relation to frailty and sarcopenia groups. If the data in the original manuscript was insufficient, the corresponding author was contacted for additional information.
Critical appraisal
Reviewers YJS and JHZ independently assessed the methodological quality of the included studies by the Methodological Index for Non-Randomized Studies (MINORS). For non-comparative studies, this instrument consists of the following eight items: (1) a clearly stated aim, (2) inclusion of consecutive patients, (3) prospective collection of data, (4) endpoints appropriate to the aim of the study, (5) unbiased assessment of the study endpoint, (6) follow-up period appropriate to the aim of the study, (7) loss to follow-up less than 5% and (8) prospective calculation of the study size. If the information is not reported, an item is scored 0 points; if the information is reported but inadequate, it scores 1 point; if the information is reported and adequate, it scores 2 points. The ideal score is 16 for non-comparative studies. During a consensus meeting, disagreement among the reviewers was discussed with a third reviewer (BRD).
Statistical analysis
If there was no available data to extract and pool, we described the outcomes in our review. The summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) of the included studies were used as measures to assess the association of sarcopenia with postoperative complications. We measured heterogeneity by using the chi2 test with significance set at P < 0.1. The I2 is also computed; it is a quantitative measure of inconsistency across studies. The following is a rough guide to interpretation of I2: 0% to 30% might not be important; 30% to 60% may represent moderate heterogeneity; 60% to 75% may represent substantial heterogeneity; 75% to 100% represents considerable heterogeneity. Clinically, there is heterogeneity because of the different evaluation methods of sarcopenia and follow-up time. In consideration of the presence of clinical heterogeneity, we used the random-effects model to synthesise all data, regardless of heterogeneity between the pooled studies in statistical order to obtain more conservative results. Publication bias was assessed by visually inspecting the funnel plots and Egger’s and Begg’s tests (P < 0.10). Subgroup analysis was conducted according to different designs of included studies. Sensitivity analysis was performed by omitting each study or included studies with lower quality. The STATA version 11.0 (Stata Corp, College Station, TX, USA) was used to perform all of the analyses. If a P value was <0.05, it was statistically significant unless otherwise specified.
Discussion
To the best of our knowledge, this is the first meta-analysis to explore systematically the impact of frailty and sarcopenia in predicting outcomes among older patients undergoing gastrectomy surgery. Although only one included study focused on frailty and gastrectomy surgery in this review, frailty was still a statistically significant factor for predicting surgical mortality in the older patient (OR 3.96, 95% CI 1.12–14.09). There was also a significant relationship between sarcopenia and postoperative complications (OR 3.12, 95% CI: 2.23–4.37) in older people. Our study indicated that assessing frailty and sarcopenia is important among older patients undergoing gastrectomy surgery.
The prevalence of sarcopenia ranged from 5% to 13% for older people aged 60 to 70 years and ranged from 11% to 50% for people aged 80 and older [
27,
28]. The prevalence of sarcopenia among patients with gastric cancer has been reported to be as high as 38% [
9]. In this systematic review, the prevalence of sarcopenia ranged from 12.5% [
23] to 57.7% [
15]. The difference in this prevalence can be explained by patients with gastric cancer being at a particularly high risk of sarcopenia and the different diagnostic criteria used in different studies. Even though these criteria had been established long ago, uniform criteria are still not established. Thus, different cut-off points for muscle mass and muscle strength were used in different studies (Table
3). In the present study, the EWGSOP and AWGS algorithm, hand grip strength (kg) and skeletal muscle mass were considered suitable methods for the diagnosis of sarcopenia. This may be for reasons of clinical heterogeneity.
Previous studies showed that the state of frailty and sarcopenia in the preoperative period were related to the occurrence of adverse postoperative outcomes, including morbidity, mortality, institutionalisation and prolonged length of hospitalisation [
2,
9,
11]. Recently, Doris Wagner and colleagues [
9] performed a systematic review regarding the role of frailty and sarcopenia in predicting outcomes among patients undergoing gastrointestinal surgery. However, this review included not only gastrectomy surgery, but also gastroesophageal surgery, colorectal surgery and hepatopancreaticobiliary surgery. Because of the high level of heterogeneity, the authors did not do meta-analysis. Furthermore, they limited their search date to January 2000 to March 2015 and only considered studies published in English. Therefore, our systematic review and meta-analysis focuses on gastrectomy surgery to reduce some of the clinical heterogeneity, giving us an opportunity to conduct the meta-analysis in this review. To the best of our knowledge, there was no systematic review that reported the role of sarcopenia in predicting morbidity and mortality of patients undergoing gastric surgery. Another systematic review conducted by Kathleen Fagard and colleagues [
29] suggested that frailty is associated with a greater risk of postoperative adverse outcomes in patients with colorectal cancer. Our study found frailty had a predictive capacity for in-hospital mortality [
20] and serious adverse events [
20], but not for 6-month mortality and length of stay [
20]. Sarcopenia is associated with mortality [
21], postoperative complications [
19,
21‐
24], hospital costs [
23], postoperative hospital stay [
23], overall survival [
24] and disease-free survival [
24].
Our results must be interpreted with caution due to the following limitations. First, although we conducted subgroup and sensitivity analyses according to the design and quality of the included studies, we did not perform the subgroup analyses according to the different sarcopenia criteria. All these factors may cause heterogeneity. Second, even frailty and sarcopenia are common in the elderly, the included criteria of our review was based on the average age of 60 years or more. However, two included studies might have included some participants younger than 60 years, which may cause some bias. Third, whether our results can be applied to Western populations remains unknown because all the included studies were from Asian countries. Fourth, none of the included studies reported quality of life as a primary outcome. Therefore, future studies should focus on more patient-centred outcomes such as quality of life. Fifth, only one study focused on the frailty assessment in predicting postoperative complications in gastric cancer surgery. However, frailty is a very important geriatric syndrome in older people. Therefore, future studies focusing on frailty and postoperative complications in gastric cancer are needed.
Conclusion
Sarcopenia and frailty seem to have a significant impact on the occurrence of adverse postoperative outcomes. Thus, it is important to define whether a patient with gastric cancer has sarcopenia and is frail in the perioperative period. Further well-designed, prospective, cohort studies focusing on frailty and quality of life with sufficient samples are needed.
Acknowledgments
We would like to thank Valerie Tanner, Saint Louis University Geriatrics Division, in St. Louis, USA, for her editing and English review expertise of the manuscript. We also want to thank Yang Ying for her contribution in the preparation of the manuscript.