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Erschienen in: Neurological Sciences 10/2020

24.04.2020 | Original Article

The impact of freezing of gait on functional dependency in Parkinson’s disease with regard to motor phenotype

verfasst von: Diego Santos-García, Teres de Deus-Fonticoba, Ester Suárez Castro, Ángel M Aneiros Díaz, María J Feal-Painceiras, Jose M Paz-González, Carlos García-Sancho, Silvia Jesús, Pablo Mir, Lluís Planellas, Juan García-Caldentey, Nuria Caballol, Inés Legarda, Jorge Hernández-Vara, Isabel González-Aramburu, María A Ávila-Rivera, María J Catalán, Víctor Nogueira, María Álvarez-Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Pilar Sánchez-Alonso, María G Alonso-Losada, Nuria López-Ariztegui, Pablo Martinez-Martin, on behalf of the COPPADIS Study Group

Erschienen in: Neurological Sciences | Ausgabe 10/2020

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Abstract

Background and objective

Freezing of gait (FOG) is a disabling symptom more frequent in Parkinson’s disease (PD) patients with postural instability gait difficulty (PIGD) phenotype. The aim of this study was to determine the prevalence of self-reported FOG in a large group of PD patients as well as assess its relationship with functional dependency with regard to motor phenotype.

Methods

The data correspond to the baseline evaluation of the COPPADIS-2015 study. Patients with FOG were identified as those with a score of 1 or greater on item-3 of the freezing of gait questionnaire (FOG-Q). Functional dependency was defined as a Schwab and England (S&E) ADL scale score less than 80%. PIGD and non-PIGD (tremor dominant + indeterminate) groups were considered regarding to motor phenotype.

Results

Among the 689 PD patients (62.6 ± 8.9 years old, 59.8% males), 240 reported FOG (34.8%), whereas 63 presented functional dependency (9.1%). A total of 22.1% of patients with FOG presented functional dependency vs. only 2.2% of those without FOG (p < 0.0001). FOG was related to functional dependency (OR = 3.470; 95%CI 1.411–8.530; p = 0.007) after adjustment to age, gender, disease duration, daily equivalent levodopa dose, comorbidity (number of non-antiparkinsonian drugs/day), motor status (UPDRS-III), PIGD phenotype, motor complications (UPDRS-IV), NMS burden (NMSS total score), cognition (PD-CRS), and mood (BDI-II). However, according to motor phenotype, FOG was related to functional dependency only in PIGD patients (OR = 7.163; 95%CI 1.206–42.564; p = 0.030).

Conclusions

Self-reported FOG is associated with functional dependency in PIGD but not in non-PIGD motor phenotype patients.
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Metadaten
Titel
The impact of freezing of gait on functional dependency in Parkinson’s disease with regard to motor phenotype
verfasst von
Diego Santos-García
Teres de Deus-Fonticoba
Ester Suárez Castro
Ángel M Aneiros Díaz
María J Feal-Painceiras
Jose M Paz-González
Carlos García-Sancho
Silvia Jesús
Pablo Mir
Lluís Planellas
Juan García-Caldentey
Nuria Caballol
Inés Legarda
Jorge Hernández-Vara
Isabel González-Aramburu
María A Ávila-Rivera
María J Catalán
Víctor Nogueira
María Álvarez-Sauco
Lydia Vela
Sonia Escalante
Esther Cubo
Pilar Sánchez-Alonso
María G Alonso-Losada
Nuria López-Ariztegui
Pablo Martinez-Martin
on behalf of the COPPADIS Study Group
Publikationsdatum
24.04.2020
Verlag
Springer International Publishing
Erschienen in
Neurological Sciences / Ausgabe 10/2020
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-020-04404-7

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