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Erschienen in: Tumor Biology 12/2014

01.12.2014 | Review

The impact of hepatitis B virus x protein and microRNAs in hepatocellular carcinoma: a comprehensive analysis

verfasst von: Li Lin, Xiaomao Yin, Xiumei Hu, Qian Wang, Lei Zheng

Erschienen in: Tumor Biology | Ausgabe 12/2014

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Abstract

microRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs, approximately 22 nucleotides (nts) in length, widely found in animals, plants, and viruses. Mature miRNAs control gene expression at a post-transcriptional level through blocking protein translation or inducing mRNA degradation. Many recent studies have shown that hepatitis B virus x protein (HBx), a viral protein with a crucial role in hepatogenesis, is associated with the regulation of miRNAs. This interaction impacts fundamental tumor processes, such as cell proliferation, differentiation, and apoptosis. In this review, we summarized the recent literature on the roles of HBx-regulated miRNAs in the pathogenesis of hepatocellular carcinoma.
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Metadaten
Titel
The impact of hepatitis B virus x protein and microRNAs in hepatocellular carcinoma: a comprehensive analysis
verfasst von
Li Lin
Xiaomao Yin
Xiumei Hu
Qian Wang
Lei Zheng
Publikationsdatum
01.12.2014
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 12/2014
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-014-2658-6

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