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23.05.2018 | Original Article

The impact of MRI steady-state sequences as an additional assessment modality in vestibular schwannoma patients after LINAC stereotactic radiotherapy or radiosurgery

verfasst von: Julian P. Sauer, Thomas M. Kinfe, MD, Bogdan Pintea, MD, Andreas Schäfer, Prof. Dr. med. Jan P. Boström, MD

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 12/2018

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Abstract

Purpose

Data concerning the clinical usefulness of steady-state sequences (SSS) for vestibular schwannomas (VS) after linear accelerator (LINAC) stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT) are scarce. The aim of the study was to investigate whether SSS provide an additional useful follow-up (FU) tool to the established thin-layered T1 sequences with contrast enhancement.

Methods

Pre- and post-treatment SSS were identified in 45 consecutive VS patients (2012–2016) with a standardized FU protocol including SSS at 2–3 months and 6 months/yearly in our prospective database and were retrospectively re-evaluated. The SSS were used throughout for the segmentation of the cochlea and partly of the trigeminal nerve in the treatment planning. Data analysis included signal conversion in SSS and possible correlation with neuro-otological outcome and volumetric assessment after a certain time interval.

Results

The series included 42 SRS and 3 SRT patients (31 female/14 male; mean age 59.3 years, range: 25–81 years). An SSS signal conversion was observed in 20 tumors (44.4%) within a mean time of 11 months (range: 7–15 months). Mean FU time was 26 months (median of 4 FU visits) and demonstrated tumor volume shrinkage in 29 cases (64.4%) correlating with FU time (p = 0.07). The incidence rate of combined shrinkage and signal conversion (48.3%) compared to those without signal conversion (51.7%) did not differ significantly (p = 0.49). In case of an early signal conversion at the first FU, a weak statistical significance (p = 0.05) for a higher shrinkage rate of VS with signal conversion was found. Side effects in cases with signal conversion (9/20, 45%) were more frequently than without signal conversion (6/25, 24%) without reaching statistical significance (p = 0.13).

Conclusion

Our data confirmed the usefulness of SSS for anatomical segmentation of VS in LINAC-SRS/SRT treatment planning and add data supporting their potential as an adjunctive FU option in VS patients.

Schmidt RF, Boghani Z, Choudhry OJ et al (2012) Incidental vestibular schwannomas: a review of prevalence, growth rate, and management challenges. Neurosurg Focus 33:E4CrossRef

Kleijwegt M, Ho V, Visser O et al (2016) Real incidence of vestibular schwannoma? Estimations from a national registry. Otol Neurotol 37:1411–1417CrossRef

Patel J, Vasan R, van Loveren H et al (2014) The changing face of acoustic neuroma management in the USA: analysis of the 1998 and 2008 patient surveys from the acoustic neuroma association. Br J Neurosurg 28:20–24CrossRef

Stepanidis K, Kessel M, Caye-Thomasen P et al (2014) Socio-demographic distribution of vestibular schwannomas in Denmark. Acta Otolaryngol 134:551–556CrossRef

Samii M, Matthies C (1997) Management of 1000 vestibular schwannomas (acoustic neuromas): hearing function in 1000 tumor resections. Neurosurgery 40:248–260 (discussion 260–242)CrossRef

Lunsford LD, Niranjan A, Flickinger JC et al (2013) Radiosurgery of vestibular schwannomas: summary of experience in 829 cases. J Neurosurg. https://doi.org/10.3171/jns.2005.102.s_supplement.0195 CrossRefPubMed

Wolbers JG, Dallenga AH, Mendez Romero A et al (2013) What intervention is best practice for vestibular schwannomas? A systematic review of controlled studies. BMJ Open. https://doi.org/10.1136/bmjopen-2012-001345 CrossRefPubMedPubMedCentral

Golfinos JG, Hill TC, Rokosh R et al (2016) A matched cohort comparison of clinical outcomes following microsurgical resection or stereotactic radiosurgery for patients with small- and medium-sized vestibular schwannomas. J Neurosurg 125:1472–1482CrossRef

Klijn S, Verheul JB, Beute GN et al (2016) Gamma Knife radiosurgery for vestibular schwannomas: evaluation of tumor control and its predictors in a large patient cohort in The Netherlands. J Neurosurg 124:1619–1626CrossRef

10.

Persson O, Bartek J Jr., Shalom NB et al (2017) Stereotactic radiosurgery vs. fractionated radiotherapy for tumor control in vestibular schwannoma patients: a systematic review. Acta Neurochir (Wien) 159:1013–1021CrossRef

11.

Putz F, Muller J, Wimmer C et al (2017) Stereotactic radiotherapy of vestibular schwannoma: hearing preservation, vestibular function, and local control following primary and salvage radiotherapy. Strahlenther Onkol 193:200–212CrossRef

12.

Badakhshi H, Muellner S, Wiener E et al (2014) Image-guided stereotactic radiotherapy for patients with vestibular schwannoma. A clinical study. Strahlenther Onkol 190:533–537CrossRef

13.

Pollock BE (2008) Vestibular schwannoma management: an evidence-based comparison of stereotactic radiosurgery and microsurgical resection. Prog Neurol Surg 21:222–227CrossRef

14.

Combs SE, Engelhard C, Kopp C et al (2015) Long-term outcome after highly advanced single-dose or fractionated radiotherapy in patients with vestibular schwannomas—pooled results from 3 large German centers. Radiother Oncol 114:378–383CrossRef

15.

Schneider T, Chapiro J, Lin M et al (2016) 3D quantitative assessment of response to fractionated stereotactic radiotherapy and single-session stereotactic radiosurgery of vestibular schwannoma. Eur Radiol 26:849–857CrossRef

16.

Dunn IF, Bi WL, Mukundan S et al (2018) Congress of neurological surgeons systematic review and evidence-based guidelines on the role of imaging in the diagnosis and management of patients with vestibular schwannomas. Neurosurgery 82:E32–E34CrossRef

17.

Chavhan GB, Babyn PS, Jankharia BG et al (2008) Steady-state MR imaging sequences: physics, classification, and clinical applications. Radiographics 28:1147–1160CrossRef

18.

Scheffler K, Lehnhardt S (2003) Principles and applications of balanced SSFP techniques. Eur Radiol 13:2409–2418CrossRef

19.

Nitz WR (2002) Fast and ultrafast non-echo-planar MR imaging techniques. Eur Radiol 12:2866–2882PubMed

20.

Park SH, Han PK, Choi SH (2015) Physiological and functional magnetic resonance imaging using balanced steady-state free precession. Korean J Radiol 16:550–559CrossRef

21.

Koos WT, Day JD, Matula C et al (1998) Neurotopographic considerations in the microsurgical treatment of small acoustic neurinomas. J Neurosurg 88:506–512CrossRef

22.

Gurgel RK, Jackler RK, Dobie RA et al (2012) A new standardized format for reporting hearing outcome in clinical trials. Otolaryngol Head Neck Surg 147:803–807CrossRef

23.

Hayhurst C, Zadeh G (2012) Tumor pseudoprogression following radiosurgery for vestibular schwannoma. Neuro-oncology 14:87–92CrossRef

24.

Yu CP, Cheung JY, Leung S et al (2000) Sequential volume mapping for confirmation of negative growth in vestibular schwannomas treated by gamma knife radiosurgery. J Neurosurg 93(Suppl 3):82–89PubMed

25.

Henzel M, Hamm K, Sitter H et al (2009) Comparison of stereotactic radiosurgery and fractionated stereotactic radiotherapy of acoustic neurinomas according to 3‑D tumor volume shrinkage and quality of life. Strahlenther Onkol 185:567–573CrossRef

26.

Coelho DH, Tang Y, Suddarth B et al (2017) MRI surveillance of vestibular schwannomas without contrast enhancement: clinical and economic evaluation. Laryngoscope. https://doi.org/10.1002/lary.26589 CrossRefPubMed

27.

van de Langenberg R, de Bondt BJ, Nelemans PJ et al (2011) Predictors of volumetric growth and auditory deterioration in vestibular schwannomas followed in a wait and scan policy. Otol Neurotol 32:338–344CrossRef

28.

van de Langenberg R, de Bondt BJ, Nelemans PJ et al (2009) Follow-up assessment of vestibular schwannomas: volume quantification versus two-dimensional measurements. Neuroradiology 51:517–524CrossRef

29.

Kondziolka D, Lunsford LD, McLaughlin MR et al (1998) Long-term outcomes after radiosurgery for acoustic neuromas. N Engl J Med 339:1426–1433CrossRef

30.

Meijer OW, Weijmans EJ, Knol DL et al (2008) Tumor-volume changes after radiosurgery for vestibular schwannoma: implications for follow-up MR imaging protocol. AJNR Am J Neuroradiol 29:906–910CrossRef

31.

Linskey ME (2000) Stereotactic radiosurgery versus stereotactic radiotherapy for patients with vestibular schwannoma: a Leksell Gamma Knife Society 2000 debate. J Neurosurg 93(Suppl 3):90–95PubMed

32.

del Valle R, Perez M, Ortiz J et al (2005) Stereotactic noninvasive volume measurement compared with geometric measurement for indications and evaluation of gamma knife treatment. J Neurosurg. https://doi.org/10.3171/jns.2005.102.s_supplement.0140 CrossRefPubMed

33.

Luppino FS, Grooters E, de Bruine FT et al (2006) Volumetrical measurements in vestibular schwannoma, the influence of slice thickness and patient’s repositioning. Otol Neurotol 27:962–968CrossRef

34.

Jacob JT, Pollock BE, Carlson ML et al (2015) Stereotactic radiosurgery in the management of vestibular schwannoma and glomus jugulare: indications, techniques, and results. Otolaryngol Clin North Am 48:515–526CrossRef

35.

Nakamura H, Jokura H, Takahashi K et al (2000) Serial follow-up MR imaging after gamma knife radiosurgery for vestibular schwannoma. AJNR Am J Neuroradiol 21:1540–1546PubMed

36.

Park CK, Kim DC, Park SH et al (2006) Microhemorrhage, a possible mechanism for cyst formation in vestibular schwannomas. J Neurosurg 105:576–580CrossRef

Titel: The impact of MRI steady-state sequences as an additional assessment modality in vestibular schwannoma patients after LINAC stereotactic radiotherapy or radiosurgery
verfasst von: Julian P. Sauer
Thomas M. Kinfe, MD
Bogdan Pintea, MD
Andreas Schäfer
Prof. Dr. med. Jan P. Boström, MD
Publikationsdatum: 23.05.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Strahlentherapie und Onkologie / Ausgabe 12/2018
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-018-1317-z

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The impact of MRI steady-state sequences as an additional assessment modality in vestibular schwannoma patients after LINAC stereotactic radiotherapy or radiosurgery

Abstract

Purpose

Methods

Results

Conclusion

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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