The Impact of Non-bone Metastatic Cancer on Musculoskeletal Health
- 22.04.2024
- REVIEW
- Verfasst von
-
Fabiola Galiana-Melendez
Fabiola Galiana-Melendez
- Department of Anatomy, Cell Biology & Physiology, 46202, Indianapolis, USA
-
Joshua R. Huot
Korrespondierender Autor Joshua R. Huot
- Department of Anatomy, Cell Biology & Physiology, 46202, Indianapolis, USA
- Indiana Center for Musculoskeletal Health, Indianapolis, USA
- Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, USA
- Department of Kinesiology, School of Health and Human Sciences, Indiana University Purdue University Indianapolis, Indianapolis, USA
- Erschienen in
- Current Osteoporosis Reports | Ausgabe 3/2024
Abstract
Purpose of Review
The purpose of this review is to discuss the musculoskeletal consequences of cancer, including those that occur in the absence of bone metastases.
Recent Findings
Cancer patients frequently develop cachexia, a debilitating condition reflected by weight loss and skeletal muscle wasting. The negative effects that tumors exert on bone health represents a growing interest amongst cachexia researchers. Recent clinical and pre-clinical evidence demonstrates cancer-induced bone loss, even in the absence of skeletal metastases. Together with muscle wasting, losses in bone demonstrates the impact of cancer on the musculoskeletal system. Identifying therapeutic targets that comprehensively protect musculoskeletal health is essential to improve the quality of life in cancer patients and survivors.
Summary
IL-6, RANKL, PTHrP, sclerostin, and TGF-β superfamily members represent potential targets to counteract cachexia. However, more research is needed to determine the efficacy of these targets in protecting both skeletal muscle and bone.
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- Titel
- The Impact of Non-bone Metastatic Cancer on Musculoskeletal Health
- Verfasst von
-
Fabiola Galiana-Melendez
Joshua R. Huot
- Publikationsdatum
- 22.04.2024
- Verlag
- Springer US
- Erschienen in
-
Current Osteoporosis Reports / Ausgabe 3/2024
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241 - DOI
- https://doi.org/10.1007/s11914-024-00872-4
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