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12.09.2019 | Original Article

The impact of physiological noise on hemodynamic-derived estimates of directed functional connectivity

verfasst von: F. Konrad Schumacher, Carmen Steinborn, Cornelius Weiller, Björn O. Schelter, Matthias Reinhard, Christoph P. Kaller

Erschienen in: Brain Structure and Function | Ausgabe 9/2019

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Abstract

Measuring the strength of directed functional interactions between brain regions is fundamental to understand neural networks. Functional near-infrared spectroscopy (fNIRS) is a suitable method to map directed interactions between brain regions but is based on the neurovascular coupling. It, thus, relies on vasomotor reactivity and is potentially biased by non-neural physiological noise. To investigate the impact of physiological noise on fNIRS-based estimates of directed functional connectivity within the rostro-caudal hierarchical organization of the prefrontal cortex (PFC), we systematically assessed the effects of pathological perturbations of vasomotor reactivity and of externally triggered arterial blood pressure (aBP) fluctuations. Fifteen patients with unilateral stenosis of the internal carotid artery (ICA) underwent multi-channel fNIRS during rest and during metronomic breathing, inducing aBP oscillations at 0.1 Hz. Comparisons between the healthy and pathological hemispheres served as quasi-experimental manipulation of the neurovascular system’s capability for vasomotor reactivity. Comparisons between rest and breathing served as experimental manipulation of two different levels of physiological noise that were expected to differ between healthy and pathological hemispheres. In the hemisphere affected by ICA stenosis, the rostro-caudal hierarchical organization of the PFC was compromised reflecting the pathological effect on the vascular and neural level. Breathing-induced aBP oscillations biased the magnitude of directed interactions in the PFC, but could be adjusted using either the aBP time series (intra-individual approach) or the aBP-induced fNIRS signal variance (inter-individual approach). Multi-channel fNIRS, hence, provides a sound basis for analyses of directed functional connectivity as potential bias due to physiological noise can be effectively controlled for.

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Titel: The impact of physiological noise on hemodynamic-derived estimates of directed functional connectivity
verfasst von: F. Konrad Schumacher
Carmen Steinborn
Cornelius Weiller
Björn O. Schelter
Matthias Reinhard
Christoph P. Kaller
Publikationsdatum: 12.09.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 9/2019
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-019-01954-1

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The impact of physiological noise on hemodynamic-derived estimates of directed functional connectivity

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