The Impact of Pretreatment PET/CT Nodal Status on Esophageal Squamous Cell Carcinoma After Neoadjuvant Chemoradiation
- 15.04.2020
- Original Scientific Report
Erschienen in:
- Verfasst von
- Jian-Xun Chen
- Ting-Yu Lu
- Hsin-Yuan Fang
- Yu-Sen Lin
- Jang-Ming Lee
- Erschienen in
- World Journal of Surgery | Ausgabe 7/2020
Abstract
Background
For advanced esophageal cancer, the clinical significance of pretreatment nodal status (cN) as determined by different examinations remains unclear.
Patients and methods
Patients with esophageal squamous cell carcinoma who underwent neoadjuvant chemoradiation and surgery were analyzed in this study. Pretreatment cN status assessed by CT, EUS, and PET/CT and clinicopathological features were used to evaluate tumor recurrence and long-term survival.
Results
Two hundred and twenty-two patients were identified in this study. Pretreatment PET/CT cN0 [odds ratio (OR) cN0 versus cN+, 5.316, p < 0.001] and pretreatment CT cN0 (OR 1.957, p = 0.032) both independently predicted ypN0. Pretreatment PET/CT cN0 was also associated with a lower recurrence rate and longer survival across the entire study group. Among patients with ypN0, pretreatment PET/CT cN+ indicated poor disease-free survival [hazard ratio (HR) 2.777, p = 0.001] and overall survival (HR 2.211, p = 0.034) compared with pretreatment PET/CT cN0, which predicted a favorable prognosis.
Conclusions
Data from the current study suggest that pretreatment lymph node status as assessed by PET/CT is strongly correlated with survival outcomes after neoadjuvant chemoradiation and surgery in patients with esophageal squamous cell carcinoma. ypN0 patients can achieve better survival outcomes when pretreatment cN0 is assessed by PET/CT.
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- Titel
- The Impact of Pretreatment PET/CT Nodal Status on Esophageal Squamous Cell Carcinoma After Neoadjuvant Chemoradiation
- Verfasst von
-
Jian-Xun Chen
Ting-Yu Lu
Hsin-Yuan Fang
Yu-Sen Lin
Jang-Ming Lee
- Publikationsdatum
- 15.04.2020
- Verlag
- Springer International Publishing
- Erschienen in
-
World Journal of Surgery / Ausgabe 7/2020
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323 - DOI
- https://doi.org/10.1007/s00268-020-05481-7
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