Erschienen in:
07.01.2021 | Sleep Breathing Physiology and Disorders • Original Article
The impact of sleeping duration on atherosclerosis in the community: insights from the Corinthia study
verfasst von:
Evangelos Oikonomou, Panagiotis Theofilis, Georgia Vogiatzi, George Lazaros, Sotirios Tsalamandris, Vasiliki Chara Mystakidi, Athina Goliopoulou, Maria Anastasiou, Petros Fountoulakis, Christos Chasikidis, Evangelia Christoforatou, Dimitris Tousoulis
Erschienen in:
Sleep and Breathing
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Ausgabe 4/2021
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Abstract
Purpose
Sleep is an essential physiologic process whose disturbances have been regarded as a risk factor in various pathophysiologic processes, including atherosclerosis and cardiovascular disease. Although the negative influence of short sleep duration has been well-established, recent data suggest a possible harmful effect of prolonged sleeping pattern.
Methods
In the setting of the Corinthia cross-sectional study, self-reported night sleep duration was recorded in 1752 apparently healthy individuals and was classified as normal sleep duration (NSD, 7–8 h), short sleep duration (SSD, 6–7 h), very short sleep duration (VSSD, < 6 h), and long sleep duration (LSD, > 8 h). Carotid duplex ultrasonography was performed in order to measure the mean and maximum carotid intima-media thickness (cIMT) as a non-invasive marker of atherosclerosis.
Results
Subjects with LSD and VSSD had significantly higher mean cIMT (VSSD: 1.02 ± 0.45 mm, SSD: 0.95 ± 0.35, NSD: 0.96 ± 0.38 mm, LSD: 1.07 ± 0.52 mm; p < 0.001) and maximum cIMT (VSSD: 1.39 ± 0.9 mm, SSD: 1.25 ± 0.71 mm, NSD: 1.23 ± 0.76 mm, LSD: 1.41 ± 0.93 mm). Following a regression analysis adjusting for known cardiovascular risk factors, individuals with LSD and VSSD had higher mean cIMT by 0.054 mm and 0.067 mm respectively compared to those with NSD.
Conclusion
A balanced sleeping duration of 6–8 h is associated with decreased mean and maximum IMT while both very short sleep duration and long sleep duration are associated with increased carotid intima-media thickness, a marker of subclinical atherosclerosis.