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Erschienen in:

14.08.2023 | Original Article

The impact of sleeve gastrectomy on polycystic ovarian syndrome: a single-center 1-year cohort study

verfasst von: Nasser Malekpour Alamdari, Gholam Hossein Monavar Sadegh, Yeganeh Farsi, Sara Besharat, Seyed Hossein Hajimirzaie, Maryam Abbasi

Erschienen in: Irish Journal of Medical Science (1971 -) | Ausgabe 2/2024

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Abstract

Background and aim

Obesity is one of the risk factors for polycystic ovarian syndrome (PCOS), and weight loss is the mainstay of treatment. This study investigates the effects of sleeve gastrectomy on clinical and paraclinical signs and symptoms of PCOS patients referred to a tertiary hospital.

Methods

Female patients with a definite diagnosis of PCOS and body mass index (BMI) > 40 kg/m2 who were candidates for sleeve gastrectomy were enrolled in this cohort study and followed for 1 year postoperatively. Clinical signs and symptoms of PCOS, sonographic examination, and laboratory hormonal assessments were assessed preoperatively and 1 year following surgery.

Results

Fifty patients enrolled in the study. The mean age of patients was 31.69 ± 9.54 years. The mean BMI before and after the surgery was 44.28 ± 3.03 and 29.37 ± 2.41 kg/m2, respectively. Oligomenorrhea was improved in 66% of patients. According to the sonographic criteria, PCOS was improved in 74% of patients. After a year post-operation, while the mean serum levels of the follicular stimulating hormone (FSH), testosterone, and dehydroepiandrostenedione have improved significantly in all patients (p < 0.001 in all), the significant decrease in serum luteinizing hormone (LH), LH/ FSH ratio, and estrogen was only noted in patients with improved clinical response (p < 0.05, p < 0.001, and p < 0.001 respectively).

Conclusion

Weight loss and improvements in hyperandrogenism following sleeve gastrectomy result in clinical and paraclinical improvement of PCOS signs and symptoms, including oligomenorrhea and ovulation induction.
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Metadaten
Titel
The impact of sleeve gastrectomy on polycystic ovarian syndrome: a single-center 1-year cohort study
verfasst von
Nasser Malekpour Alamdari
Gholam Hossein Monavar Sadegh
Yeganeh Farsi
Sara Besharat
Seyed Hossein Hajimirzaie
Maryam Abbasi
Publikationsdatum
14.08.2023
Verlag
Springer International Publishing
Erschienen in
Irish Journal of Medical Science (1971 -) / Ausgabe 2/2024
Print ISSN: 0021-1265
Elektronische ISSN: 1863-4362
DOI
https://doi.org/10.1007/s11845-023-03488-2

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