Background
Methods
Patients
Statistical analysis
Results
Characteristics of colorectal cancer patients
Characteristic | Diabetes (%) | Non-diabetes (%) | P value |
---|---|---|---|
N = 283 (23.6%) | N = 914 (76.4%) | ||
Age (mean ± SD) | 67.63 ± 10.55 | 63.11 ± 13.45 | < 0.001 |
Gender | |||
Male/Female | 157 (55.5)/126 (45) | 516 (56.5)/398 (43.5) | 0.772 |
Tumor size | |||
≥5 cm/<5 cm | 116 (41)/167 (59) | 404 (44.2)/510 (55.8) | 0.315 |
Tumor location | |||
Colon/Rectum | 199 (70.3)/84 (29.7) | 629 (68.8)/285 (31.2) | 0.633 |
Histological type | |||
Well/Moderately/Poorly | 23 (8.1)/230 (81.3)/30 (10.6) | 68(7.4)/747(81.8)/99(10.8) | 0.582 |
AJCCa Stage | |||
I/II/III/IV | 52(18.3)/109(38.5)/85(30)/37(13.2) | 155(17)/316(34.6)/280(30.6)/163(17.8) | 0.396 |
Tumor depth | |||
T1/T2/T3/T4 | 20(7.0)/43(15.2)/210(74.2)/10(3.6) | 61(6.7)/136(14.9)/652(71.3)/67(7.1) | 0.305 |
Lympho Nodes metastases | |||
N0/N1/N2 | 171(60.4)/76(26.9)/36(12.7) | 523(57.2)/233(25.5)/158(17.3) | 0.322 |
Vascular invasion | |||
Yes/No | 95 (33.6)/188 (66.4) | 614 (67.2)/300 (32.8) | 0.764 |
Perineurial invasion | |||
Yes/No | 102 (36)/181 (64) | 344 (37.6)/570 (62.4) | 0.689 |
Serum Albumin level | |||
<3.5 gm/dl/≥3.5 gm/dl | 127 (44.9)/156 (55.1) | 349 (38.2)/565 (61.8) | 0.018 |
Pre-op Serum CEAb level | |||
≥5 ng/ml/<5 ng/ml | 160 (56.6)/123 (43.5) | 400 (43.8)/514 (56.2) | < 0.001 |
Post-op Serum CEAb level | |||
≥5 ng/ml/<5 ng/ml | 93 (32.9)/190 (67.1) | 245 (26.8)/669 (73.2) | 0.024 |
Cardiac disease | |||
Yes/No | 173 (61.1)/110 (38.9) | 311 (34)/603 (66) | < 0.001 |
Pulmonary disease | |||
Yes/No | 4 (1.4)/279 (98.6) | 12 (1.3)/902 (98.7) | 0.898 |
Renal disease | |||
Yes/No | 15 (5.3)/268 (94.7) | 40 (4.4)/874 (95.6) | 0.517 |
Second Primary Cancer | |||
Yes/No | 27 (9.5)/256 (90.5) | 55 (6)/859 (94) | 0.040 |
Chemotherapy | |||
Yes/No | 185 (65.4)/98 (35.6) | 607 (66.4)/307 (33.6) | 0.756 |
Body Mass Index (mean ± SD) | 24.36 ± 3.65 | 23.29 ± 3.75 | < 0.001 |
Impact on overall survival (OS) and cancer-specific survival (CSS)
Parameters | Number | Univariate analysis Hazard ratio (95% CI) | P value | Multivariate analysis Hazard ratio (95% CI) | P value |
---|---|---|---|---|---|
DM (yes/no) | 283/914 | 1.02(0.81-1.27) | .888 | 0.94(0.71-1.24) | 0.642 |
Age (≥65/<65)years | 632/565 | 1.33(1.09-1.62) | .004 | 1.36(1.05-1.76) | 0.021 |
Sex (Male/Female) | 674/523 | 1.13(0.93-1.37) | .221 | 1.09(0.85-1.40) | 0.491 |
Location (Rectum/Colon) | 369/828 | 0.89(0.65-1.00) | .048 | 0.80(0.61-1.05) | 0.114 |
Tumor size (≥5/<5)cm | 518/679 | 1.47(1.21-1.78) | < .001 | 1.12(0.87-1.44) | 0.368 |
BMIa (<22/≥22) kg/M2 | 394/803 | 1.39(1.13-1.70) | .001 | 1.14(0.88-1.48) | 0.311 |
Albumin (<3.5/≥3.5)gm/dl | 476/721 | 1.83(1.48-2.25) | < .001 | 1.32(1.02-1.70) | 0.037 |
Histology (PD/MD + WDb) | 135/1062 | 1.93(1.48-2.52) | < .001 | 1.45(1.04-2.02) | 0.030 |
AJCCc stage (III&IV/I&II) | 565/632 | 3.36(2.73-4.14) | < .001 | 1.32(1.02-1.70) | 0.037 |
Pre-op CEAd (≥5/<5) ng/ml | 559/638 | 2.86(2.31-3.53) | < .001 | 1.26(0.93-1.70) | 0.143 |
Post-op CEAd (≥5/<5) ng/ml | 338/859 | 5.30(4.30-6.54) | < .001 | 3.61(2.80-4.64) | < 0.001 |
Vascular invasion (yes/no) | 395/802 | 2.79(2.28-3.41) | < .001 | 1.58(1.22-2.05) | < 0.001 |
Perineurial invasion (yes/no) | 447/750 | 2.27(1.86-2.78) | < .001 | 1.79(1.39-2.30) | < 0.001 |
Parameters | Number | Univariate analysis Hazard ratio (95% CI) | P value | Multivariate analysis Hazard ratio (95% CI) | P value |
---|---|---|---|---|---|
DM (yes/no) | 283/912 | 0.91(0.72-1.17) | .463 | 0.83(0.61-1.23) | 0.234 |
Age (≥65/<65)years | 632/565 | 1.19(0.97-1.46) | .092 | 1.27(0.97-1.67) | 0.083 |
Sex (Male/Female) | 674/523 | 1.08(0.88-1.32) | .467 | 1.05(0.81-1.37) | 0.692 |
Location (Rectum/Colon) | 369/828 | 0.81(0.64-1.00) | .058 | 0.82(0.62-1.09) | 0.176 |
Tumor size (≥5/<5)cm | 518/679 | 1.42(1.15-1.74) | < .001 | 1.13(0.86-1.47) | 0.384 |
BMIa (<22/≥22) kg/M2 | 394/803 | 1.43(1.16-1.77) | < .001 | 1.16(0.88-1.51) | 0.301 |
Albumin (<3.5/≥3.5)gm/dl | 476/721 | 1.79(1.44-2.23) | < .001 | 1.40(1.08-1.82) | 0.011 |
Histology (PD/MD + WDb) | 135/1062 | 1.89(1.42-2.52) | < .001 | 1.35(.094-1.94) | 0.124 |
AJCCc stage (III&IV/I&II) | 565/632 | 3.95(3.15-4.96) | < .001 | 2.22(1.65-2.99) | < 0.001 |
Pre-op CEAd (≥5/<5) ng/ml | 559/638 | 2.98(2.38-3.73) | < .001 | 1.25(0.91-1.73) | 0.225 |
Post-op CEAd (≥5/<5) ng/ml | 338/859 | 5.47(4.39-6.81) | < .001 | 3.71(2.84-4.83) | < 0.001 |
Vascular invasion (yes/no) | 395/802 | 2.97(2.40-3.67) | < .001 | 1.54(1.18-2.01) | 0.002 |
Perineurial invasion (yes/no) | 447/750 | 2.51(2.03-3.10) | < .001 | 1.82(1.40-2.37) | < 0.001 |