Background
Solid pseudopapillary tumor (SPT) of the pancreas, otherwise known as solid and cystic tumor or Frantz tumor, is a rare but characteristic neoplasm, with unknown etiopathogenesis, accounting for 0.2 to 2.7% of all pancreatic tumors and less than 5% of pancreatic cystic tumors [
1‐
3]. It is defined as an exocrine pancreatic neoplasia that mainly affects women between the second and third decade of life and is rarely seen in men or children [
2]. When present in men, it has greater malignant potential with a worse prognosis [
4]. It accounts for approximately 8 to 16% of pancreatic tumors in children [
5].
Symptoms of SPT depend on the location and size of the tumor but usually are nonspecific, with abdominal pain being the most common in approximately one-third of patients [
6]. Several imaging techniques can be used to diagnose pancreatic masses, such as abdominal ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasound (EUS). EUS has assumed a very important role in the diagnosis of pancreatic lesions, providing a better evaluation of the morphologic characteristics of the lesions and the possibility of guiding fine-needle aspiration (FNA) punctures for tissue sampling with a low risk of complications and increased diagnostic accuracy [
7]. SPT can present as a solid, cystic, or mixed lesion [
8,
9].
The treatment of choice is a complete curative surgical resection of the lesion. The long-term prognosis is excellent, since it has a generally indolent behavior and a low degree of malignancy [
5].
Here we report two cases of SPT diagnosed by preoperative EUS-FNA, presenting distinct clinical outcomes after a proper surgical approach.
Discussion
SPT of the pancreas was first described by Frantz in 1959 [
5]. It is a very rare type of pancreatic neoplasm with a low rate of progression to malignancy [
10]. Under 2800 cases have been reported until the year 2012 [
11], with the largest single institution case series of 37 patients who underwent surgical resection of SPT [
12]. It affects mainly young women (approximately 90% of cases), but can affect men and women of any age group [
4]. The most commonly affected areas are the body and tail of the pancreas, corresponding to approximately 60% of the diagnosed cases. Unlike most reported cases, our patients presented lesions at the uncinate process and at the transition between the body and neck of the pancreas [
11].
The symptoms of SPT are usually nonspecific, with abdominal pain being the most common, accounting for approximately 37.6% of the cases. Other signs and symptoms such as jaundice, abdominal fullness, anorexia, nausea, vomiting, and weight loss may also be present. Approximately one-third of the patients are asymptomatic [
6]. As reported in the literature, our patients presented with nonspecific symptoms. With the recent advances of radiologic diagnostic imaging methods, SPT has been increasingly diagnosed in general clinical practice. US, CT, MRI, and EUS are the most widely used methods for pancreatic masses evaluation. Over the years, EUS-FNA has become the gold standard method for the diagnosis of pancreatic solid masses [
13]. The sensitivity and specificity of EUS-FNA for the diagnosis of pancreatic neoplasms ranges from 80 to 90% and from 85 to 96%, respectively [
13]. EUS commonly identifies SPT as a well circumscribed, solid, hypoechogenic, heterogeneous tumor with cystic components and calcifications [
14].
In our two cases, EUS showed solid hypoechoic lesion with cystic components with regular contours but it was not heterogeneous. Since EUS-FNA is considered the gold standard for pancreatic lesions, EUS-FNA was performed with histopathological diagnostic confirmation of SPT.
The diagnosis of SPT with EUS-FNA has been increasing in popularity as shown in a case series of 34 patients [
15], where EUS-FNA improved the preoperative diagnostic yield of SPT, correctly identifying 82% of patients when compared to CT scan findings (23.5%) and EUS (41.2%). These findings suggest that patients who do not have a clear diagnosis of an SPT using only image studies may benefit from EUS-FNA [
15]. The operating characteristics of EUS-FNA for diagnostic solid pancreatic masses were: sensitivity 95% (95% CI, 93.2–95.4), specificity 92% (95% CI, 86.6–95.7), positive predictive value 98% (95% CI, 97–99), and negative predictive value 80% (95% CI, 74.9–82.7). The overall accuracy of EUS-FNA was 94.1% (95% CI, 92.0–94).
Complications related to EUS-FNA are only reported in approximately 1% of patients. The most common complication is acute pancreatitis; other reported complications are abdominal pain, fever, vomiting, and bleeding [
7]. Both of our cases presented no complications related to the EUS-FNA procedure.
An anatomopathological study revealed pseudopapillary areas with fibrovascular stems or rosette-like structures secondary to the low cohesion of neoplastic cells [
16]. An immunohistochemical study stained positive for beta-catenin, vimentin, progesterone receptor, CD56, neuron-specific coil, CD10, cyclin D1, E-membranous, and E-cadherin [
6]. Unlike other pancreatic tumors, the most sensitive specific marker for SPT is the abnormal nuclear expression of beta-catenin [
17]. The Ki-67 index has been suggested as an indicator of malignant potential and poor prognosis in SPT. A low Ki-67 index (≤ 5%) indicates slow tumor growth [
18]. Microscopic evaluation of the two reported cases revealed intact papillary structures with fibrovascular stems. In the second case, diagnostic confirmation was still necessary through an immunohistochemical study, confirming the suspected diagnosis of SPT through the expression of beta-catenin. Immunohistochemistry also showed a low mitotic Ki-67 index, suggesting good prognosis.
Surgical treatment of SPT offers an excellent overall survival rate, greater than 95% [
6]. The surgical procedure to be performed will depend on the topography and level of tumor invasion [
19]. After diagnostic confirmation by EUS-FNA, our two patients underwent different surgical procedures according to lesion topography. Patient 1 underwent duodenopancreatectomy, while patient 2 underwent a body-tail pancreatectomy with splenectomy. The outcomes of our two case reports were different, with one patient presenting a favorable evolution, while the other patient died due to postoperative complications. The different evolutions of the cases may justify the view that more aggressive surgery (duodenopancreatectomy) could have been performed on the patient with uncinated pancreatic process neoplastic invasion. The reported mortality rate related to postoperative complications after SPT resection is only 1% [
5].
Neither of our patients had neoplastic metastases, although it is known that despite the low malignant potential, up to 15% of cases of SPT develop distant metastases [
20]. The most common sites of metastasis are the liver and lymph nodes. Tumor recurrence may occur in approximately 6% of cases, requiring rigorous follow-up [
5].
In this context, EUS-FNA is a very important method that presents excellent diagnostic rates and provides material for cytological and histological evaluation of SPT.