Skip to main content
Erschienen in: International Ophthalmology 3/2017

12.05.2016

The importance of quantitative measurement methods for uveitis: laser flare photometry endorsed in Europe while neglected in Japan where the technology measuring quantitatively intraocular inflammation was developed

verfasst von: Carl P. Herbort, Ilknur Tugal-Tutkun

Erschienen in: International Ophthalmology | Ausgabe 3/2017

Einloggen, um Zugang zu erhalten

Abstract

Laser flare photometry (LFP) is an objective and quantitative method to measure intraocular inflammation. The LFP technology was developed in Japan and has been commercially available since 1990. The aim of this work was to review the application of LFP in uveitis practice in Europe compared to Japan where the technology was born. We reviewed PubMed articles published on LFP and uveitis. Although LFP has been largely integrated in routine uveitis practice in Europe, it has been comparatively neglected in Japan and still has not received FDA approval in the USA. As LFP is the only method that provides a precise measure of intraocular inflammation, it should be used as a gold standard in uveitis centres worldwide.
Literatur
1.
Zurück zum Zitat Sawa M, Tsurimaki Y, Tsuru T, Shimizu H (1988) New quantitative method to determine protein concentration and cell number in aqueous in vivo. Jpn J Ophthalmol 32:132–142PubMed Sawa M, Tsurimaki Y, Tsuru T, Shimizu H (1988) New quantitative method to determine protein concentration and cell number in aqueous in vivo. Jpn J Ophthalmol 32:132–142PubMed
2.
Zurück zum Zitat Tugal-Tutkun I, Herbort CP (2010) Laser flare photometry: a noninvasive, objective and quantitative method to measure intraocular inflammation. Int Ophthalmol 30:453–464CrossRefPubMed Tugal-Tutkun I, Herbort CP (2010) Laser flare photometry: a noninvasive, objective and quantitative method to measure intraocular inflammation. Int Ophthalmol 30:453–464CrossRefPubMed
3.
Zurück zum Zitat Herbort CP, Guex-Crosier Y, de Ancos E, Pittet N (1997) Use of laser flare photometry (LFP) to assess and monitor inflammation in uveitis. Ophthalmology 104:64–72CrossRefPubMed Herbort CP, Guex-Crosier Y, de Ancos E, Pittet N (1997) Use of laser flare photometry (LFP) to assess and monitor inflammation in uveitis. Ophthalmology 104:64–72CrossRefPubMed
4.
Zurück zum Zitat Guex-Crosier Y, Pittet N, Herbort CP (1994) Evaluation of laser flare-cell photometry in the appraisal and management of intraocular inflammation in uveitis. Ophthalmology 101:728–735CrossRefPubMed Guex-Crosier Y, Pittet N, Herbort CP (1994) Evaluation of laser flare-cell photometry in the appraisal and management of intraocular inflammation in uveitis. Ophthalmology 101:728–735CrossRefPubMed
5.
Zurück zum Zitat Guex-Crosier Y, Pittet N, Herbort CP (1995) Sensitivity of laser flare photometry to monitor inflammation in uveitis of the posterior segment. Ophthalmology 102:613–621CrossRefPubMed Guex-Crosier Y, Pittet N, Herbort CP (1995) Sensitivity of laser flare photometry to monitor inflammation in uveitis of the posterior segment. Ophthalmology 102:613–621CrossRefPubMed
6.
Zurück zum Zitat Takayama K, Tanaka A, Ishikawa S, Mochizuki M, Takeuchi M (2016) Comparison between outcomes of vitrectomy in granulomatous and nongranulomatous uveitis. Ophthalmologica 235:18–25CrossRefPubMed Takayama K, Tanaka A, Ishikawa S, Mochizuki M, Takeuchi M (2016) Comparison between outcomes of vitrectomy in granulomatous and nongranulomatous uveitis. Ophthalmologica 235:18–25CrossRefPubMed
7.
Zurück zum Zitat Herbort CP (2009) Laser flare photometry. Chapter 3. In: Gupta A, Gupta V, Herbort CP, Khairallah M (eds) Uveitis text and imaging. Jaypee, New Delhi, pp 28–49 Herbort CP (2009) Laser flare photometry. Chapter 3. In: Gupta A, Gupta V, Herbort CP, Khairallah M (eds) Uveitis text and imaging. Jaypee, New Delhi, pp 28–49
8.
Zurück zum Zitat Bernasconi O, Papadia M, Herbort CP (2010) Sensitivity of laser flare photometry compared to slit-lamp cell evaluation to monitor anterior chamber inflammation in uveitis. Int Ophthalmol 30:495–500CrossRefPubMed Bernasconi O, Papadia M, Herbort CP (2010) Sensitivity of laser flare photometry compared to slit-lamp cell evaluation to monitor anterior chamber inflammation in uveitis. Int Ophthalmol 30:495–500CrossRefPubMed
10.
Zurück zum Zitat Shah SM, Spalton DJ, Taylor JC (1992) Correlations between laser flare measurements and anterior chamber protein concentrations. Invest Ophthalmol Vis Sci 33:2878–2884PubMed Shah SM, Spalton DJ, Taylor JC (1992) Correlations between laser flare measurements and anterior chamber protein concentrations. Invest Ophthalmol Vis Sci 33:2878–2884PubMed
11.
Zurück zum Zitat El-Maghraby A, Marzouki A, Matheen TM, Souchek J, Van Der Karr M (1992) Reproducibility and validity of laser flare/cell meter measurement as an objective method of assessing intraocular inflammation. Arch Ophthalmol 110:960–962CrossRefPubMed El-Maghraby A, Marzouki A, Matheen TM, Souchek J, Van Der Karr M (1992) Reproducibility and validity of laser flare/cell meter measurement as an objective method of assessing intraocular inflammation. Arch Ophthalmol 110:960–962CrossRefPubMed
12.
Zurück zum Zitat Rodinger ML, Hessemer V, Schmitt K, Schickel B (1993) Reproducibility of in vivo determination of protein and particle concentration with the laser flare-cell photometer. Ophthalmologe 90:742–745PubMed Rodinger ML, Hessemer V, Schmitt K, Schickel B (1993) Reproducibility of in vivo determination of protein and particle concentration with the laser flare-cell photometer. Ophthalmologe 90:742–745PubMed
13.
Zurück zum Zitat el-Harazi SM, Feldman RM, Chuang AZ, Ruiz RS, Villanueva G (1998) Reproducibility of the laser flare meter and laser cell counter in assessing anterior chamber inflammation following cataract surgery. Ophthalic Surg Lasers 29:380–384 el-Harazi SM, Feldman RM, Chuang AZ, Ruiz RS, Villanueva G (1998) Reproducibility of the laser flare meter and laser cell counter in assessing anterior chamber inflammation following cataract surgery. Ophthalic Surg Lasers 29:380–384
14.
Zurück zum Zitat Agrawal R, Keane PA, Singh J, Saihan Z, Kontos A, Pavésio CE (2016) Comparative analysis of anterior chamber grading between clinicians with different levels of experience and laser flare photometry. Ocul Immunol Inflamm 24:184–193CrossRefPubMed Agrawal R, Keane PA, Singh J, Saihan Z, Kontos A, Pavésio CE (2016) Comparative analysis of anterior chamber grading between clinicians with different levels of experience and laser flare photometry. Ocul Immunol Inflamm 24:184–193CrossRefPubMed
15.
Zurück zum Zitat Jabs DA, Nussenblatt RB, Rosenbaum JT (2005) Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 140:509–516CrossRefPubMed Jabs DA, Nussenblatt RB, Rosenbaum JT (2005) Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 140:509–516CrossRefPubMed
16.
Zurück zum Zitat Hogan MJ, Kimura SJ, Thygeson P (1959) Signs and symptoms of uveitis. 1. Anterior uveitis. Am J Ophtalmol 47:155–170CrossRef Hogan MJ, Kimura SJ, Thygeson P (1959) Signs and symptoms of uveitis. 1. Anterior uveitis. Am J Ophtalmol 47:155–170CrossRef
17.
Zurück zum Zitat Tanaka R, Murata H, Takamoto M, Ohtomo K, Okinaga K, Yoshida A, Kawashima H, Nakahara H, Fujino Y, Kaburaki T (2015) Behçet’s disease ocular attack score 24 and visual outcome in patients with Behçet’s disease. Br J Ophthalmol. doi:10.1136/bjophthalmol-2015-307362 PubMed Tanaka R, Murata H, Takamoto M, Ohtomo K, Okinaga K, Yoshida A, Kawashima H, Nakahara H, Fujino Y, Kaburaki T (2015) Behçet’s disease ocular attack score 24 and visual outcome in patients with Behçet’s disease. Br J Ophthalmol. doi:10.​1136/​bjophthalmol-2015-307362 PubMed
18.
Zurück zum Zitat Tugal-Tutkun I, Cingü K, Kir N, Yeniad B, Urgancioglu M, Gül A (2008) Use of laser flare-cell photometry to quantify intraocular inflammation in patients with Behçet uveitis. Graefes Arch Clin Exp Ophthalmol 246:1169–1177CrossRefPubMed Tugal-Tutkun I, Cingü K, Kir N, Yeniad B, Urgancioglu M, Gül A (2008) Use of laser flare-cell photometry to quantify intraocular inflammation in patients with Behçet uveitis. Graefes Arch Clin Exp Ophthalmol 246:1169–1177CrossRefPubMed
20.
Zurück zum Zitat Tugal-Tutkun I, Herbort CP, Khairallah M, Angiography Scoring for Uveitis Working Group (ASUWOG) (2010) Scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading of posterior segment inflammation (dual fluorescein and ICG angiographic scoring system for uveitis). Int Ophthalmol 30:539–552CrossRefPubMed Tugal-Tutkun I, Herbort CP, Khairallah M, Angiography Scoring for Uveitis Working Group (ASUWOG) (2010) Scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading of posterior segment inflammation (dual fluorescein and ICG angiographic scoring system for uveitis). Int Ophthalmol 30:539–552CrossRefPubMed
21.
Zurück zum Zitat Tugal-Tutkun I, Herbort CP, Khairallah M, Mantovani A (2010) Interobserver agreement in scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading pf posterior segment inflammation. Ocul Immunol Inflamm 18:385–389CrossRefPubMed Tugal-Tutkun I, Herbort CP, Khairallah M, Mantovani A (2010) Interobserver agreement in scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading pf posterior segment inflammation. Ocul Immunol Inflamm 18:385–389CrossRefPubMed
22.
Zurück zum Zitat Herbort CP, Tugal-Tutkun I (2010) Laser flare (cell) photometry: 20 years already. (Editorial). Int Ophthalmol 30:445–447CrossRefPubMed Herbort CP, Tugal-Tutkun I (2010) Laser flare (cell) photometry: 20 years already. (Editorial). Int Ophthalmol 30:445–447CrossRefPubMed
Metadaten
Titel
The importance of quantitative measurement methods for uveitis: laser flare photometry endorsed in Europe while neglected in Japan where the technology measuring quantitatively intraocular inflammation was developed
verfasst von
Carl P. Herbort
Ilknur Tugal-Tutkun
Publikationsdatum
12.05.2016
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 3/2017
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-016-0253-0

Weitere Artikel der Ausgabe 3/2017

International Ophthalmology 3/2017 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.