Erschienen in:
12.02.2020 | Current Concepts in Spinal Fusion/Commentary
The Importance of Surface Technology in Spinal Fusion
verfasst von:
Yoshihiro Katsuura, MD, Joshua Wright-Chisem, MD, Adam Wright-Chisem, MD, Sohrab Virk, MD, Steven McAnany, MD
Erschienen in:
HSS Journal ®
|
Ausgabe 2/2020
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Excerpt
There is room for improvement in current rates of successful spinal fusion; one natural area of focus is the interaction between implants and bone. The chemical composition, hydrophilicity, and overall roughness of the surface of an implant play roles in bony fusion [
16,
19,
20,
21]. This is because in the first stages of osteointegration, the implant is coated with proteins from the blood and serum—a process that is highly dependent on the chemical and topographical nature of the implant [
20]. This protein layer facilitates the migration of mesenchymal progenitor cells into the implant surface via the α2β1 integrin receptor, a major collagen type 1 receptor [
20]. These cells must then differentiate into an osteoblastic lineage to form new bone, a process that, again, is driven by the surface properties of the implant, with rough surfaces favoring osteoblastic differentiation [
2]. Moreover, the shape of the substructure influences the shape of the cells, promoting differentiation into an osteoblastic form [
20,
37]. …
