Background
Methods
Patients
Study design
Statistical methods
Results
Increased levels of CYFRA21-1 significantly correlated with metastatic disease
No. (%) | |||||
---|---|---|---|---|---|
Neg | Moderate | High | Total |
P Value | |
1–3 fold | >3 fold | ||||
(n = 115) | (n = 190) | (n = 127) | (n = 432) | ||
Basic Characteristics | |||||
Age | |||||
< 45 | 5 (4.3) | 16 (8.4) | 7 (5.5) | 28 | 0.101 |
45–60 | 58 (50.4) | 72 (37.9) | 46 (36.2) | 176 | |
> 60 | 52 (45.3) | 102 (53.7) | 74 (58.3) | 228 | |
Sex | |||||
Male | 79 (68.7) | 134 (70.5) | 83 (65.4) | 296 | 0.623 |
Female | 36 (31.3) | 56 (29.5) | 44 (34.6) | 136 | |
Histological classification | |||||
SCC | 21 (18.3) | 42 (22.1) | 56 (44.1) | 119 | |
ADC | 64 (55.7) | 103 (54.2) | 58 (45.7) | 225 |
<0.001**
|
SCLC | 22 (19.1) | 34 (17.9) | 7 (5.5) | 63 | |
Others | 8 (6.9) | 11 (5.8) | 6 (4.7) | 25 | |
Stages | |||||
I | 12 (10.4) | 6 (3.2) | 0 (0.0) | 18 |
<0.001**
|
II | 7 (6.1) | 8 (4.2) | 2 (1.6) | 17 | |
III | 40 (34.8) | 50 (26.3) | 38 (29.9) | 128 | |
IV | 49 (42.6) | 115 (60.5) | 79 (62.2) | 243 | |
#Un. | 7 (6.1) | 11 (5.8) | 8 (6.3) | 26 | |
Smoke status | |||||
No | 55 (47.8) | 80 (42.1) | 56 (44.1) | 191 | 0.621 |
Yes | 60 (52.2) | 110 (57.9) | 71 (55.9) | 241 | |
Metastasis | |||||
Brain | |||||
No | 104 (90.4) | 162 (85.3) | 105 (82.7) | 371 | 0.212 |
Yes | 11 (9.6) | 28 (14.7) | 22 (17.3) | 61 | |
Bone | |||||
No | 101 (90.4) | 142 (74.7) | 92 (72.4) | 335 |
<0.01**
|
Yes | 14 (9.6) | 48 (25.3) | 35 (27.6) | 97 | |
Liver | |||||
No | 113 (98.3) | 170 (89.5) | 108 (85.0) | 391 |
<0.01**
|
Yes | 2 (1.7) | 20 (10.5) | 19 (15.0) | 41 | |
Adrenal gland | |||||
No | 113 (98.3) | 173 (91.1) | 119 (93.7) | 405 |
<0.05*
|
Yes | 2 (1.7) | 17 (8.9) | 8 (6.3) | 27 | |
Lymph node | |||||
No | 66 (57.4) | 68 (35.8) | 37 (29.1) | 171 |
<0.001***
|
Yes | 49 (42.6) | 122 (64.2) | 90 (70.9) | 261 | |
Intrapulmonary | |||||
No | 105 (91.3) | 163 (85.8) | 111 (87.4) | 379 | 0.360 |
Yes | 21 (9.1) | 58 (14.9) | 35 (14.2) | 53 | |
Pleural | |||||
No | 100 (87.0) | 170 (89.5) | 98 (77.2) | 368 |
<0.01**
|
Yes | 15 (13.0) | 20 (10.5) | 29 (22.8) | 64 | |
Mediastinal | |||||
No | 113 (98.3) | 185 (97.4) | 120 (94.5) | 418 | 0.208 |
Yes | 2 (1.7) | 5 (2.6) | 7 (5.5) | 14 | |
Peritoneum | |||||
No | 115 (100) | 178 (93.7) | 116 (91.3) | 409 |
<0.01**
|
Yes | 0 (0.0) | 12 (6.3) | 11 (8.7) | 23 | |
Validation group | |||||
No. (%) | |||||
Neg | Moderate | High | Total |
P Value | |
1–3 fold | >3 fold | ||||
(n = 116) | (n = 200) | (n = 120) | (n = 436) | ||
Basic Characteristics | |||||
Age | |||||
8 (6.9) | 13 (6.5) | 10 (8.3) | 31 | 0.073 | |
52 (44.8) | 61 (30.5) | 36 (30.0) | 149 | ||
56 (48.3) | 126 (63.0) | 74 (61.7) | 256 | ||
Sex | |||||
74 (63.8) | 139 (69.5) | 94 (78.3) | 307 |
<0.05*
| |
42 (36.2) | 61 (30.5) | 26 (21.7) | 129 | ||
Histological classification | |||||
15 (12.9) | 43 (21.5) | 38 (31.7) | 96 |
<0.001**
| |
56 (48.3) | 98 (49.0) | 66 (55.0) | 220 | ||
40 (34.5) | 47 (23.5) | 9 (7.5) | 96 | ||
5 (4.3) | 12 (6.0) | 7 (5.8) | 24 | ||
Stages | |||||
9 (7.8) | 9 (4.5) | 4 (3.3) | 22 |
<0.05*
| |
15 (12.9) | 20 (10.0) | 3 (2.5) | 38 | ||
23 (19.8) | 43 (21.5) | 23 (19.2) | 89 | ||
61 (52.6) | 115 (57.5) | 86 (71.7) | 262 | ||
8 (6.9) | 13 (6.5) | 4 (3.3) | 25 | ||
Smoke status | |||||
63 (54.3) | 86 (43.0) | 42 (35.0) | 191 |
<0.05*
| |
53 (45.7) | 114 (57.0) | 78 (65.0) | 245 | ||
Metastasis | |||||
Brain | |||||
102 (87.9) | 183 (91.5) | 93 (77.5) | 378 |
<0.01**
| |
14 (12.1) | 17 (8.5) | 27 (22.5) | 58 | ||
Bone | |||||
101 (87.1) | 160 (80.0) | 79 (65.8) | 340 |
<0.001***
| |
15 (12.9) | 40 (20.0) | 41 (34.2) | 96 | ||
Liver | |||||
110 (94.8) | 177 (88.5) | 96 (80.0) | 383 |
<0.01**
| |
6 (5.2) | 23 (11.5) | 24 (20.0) | 53 | ||
Adrenal gland | |||||
107 (92.2) | 192 (96.0) | 110 (91.7) | 409 | 0.213 | |
9 (7.8) | 8 (4.0) | 10 (8.3) | 27 | ||
Lymph node | |||||
58 (50.0) | 68 (34.0) | 41 (34.2) | 167 |
<0.01**
| |
58 (50.0) | 132 (66.0) | 79 (65.8) | 269 | ||
Intrapulmonary | |||||
105 (90.5) | 169 (84.5) | 101 (84.2) | 375 | 0.262 | |
11 (9.5) | 31 (15.5) | 19 (15.8) | 61 | ||
Pleural | |||||
107 (92.2) | 168 (81.5) | 95 (79.2) | 365 |
<0.05*
| |
9 (7.8) | 37 (18.5) | 25 (20.8) | 71 | ||
Mediastinal | |||||
114 (98.3) | 192 (96.0) | 112 (93.3) | 418 | 0.161 | |
2 (1.7) | 8 (4.0) | 8 (6.7) | 18 | ||
Peritoneum | |||||
111 (95.7) | 189 (94.5) | 99 (82.5) | 399 |
<0.01**
| |
5 (4.3) | 11 (5.5) | 21 (17.5) | 37 |
Correlation of CYFRA21-1 and NSE with metastases in ADC and SCC, respectively
No. (%) | |||||
---|---|---|---|---|---|
Neg | Moderate | High | Total |
P Value | |
(1–3 fold) | >3 fold | ||||
(n = 120) | (n = 201) | (n = 124) | (n = 445) | ||
Basic Characteristics | |||||
Age | |||||
< 45 years | 5 (4.2) | 22 (11.0) | 14 (11.3) | 41 |
<0.05*
|
45–60 years | 57 (47.5) | 66 (32.8) | 38 (30.6) | 161 | |
> 60 years | 58 (48.3) | 113 (56.2) | 72 (58.1) | 243 | |
Sex | |||||
Male | 65 (54.2) | 112 (55.7) | 71 (57.3) | 248 | 0.889 |
Female | 55 (45.8) | 89 (44.3) | 53 (42.7) | 197 | |
Stages | |||||
I + II | 24 (20.0) | 14 (7.0) | 5 (4.0) | 43 |
<0.001**
|
III + IV | 91 (75.8) | 181 (90.0) | 116 (93.6) | 388 | |
Unknown | 4 (4.2) | 6 (3.0) | 3 (2.4) | 14 | |
Smoke status | |||||
No | 79 (65.9) | 119 (59.2) | 68 (54.8) | 266 | 0.208 |
Yes | 41 (34.1) | 82 (40.8) | 56 (45.2) | 179 | |
Metastasis | |||||
Brain | |||||
No | 107 (89.2) | 164 (81.6) | 95 (76.6) | 366 |
<0.05*
|
Yes | 13 (10.8) | 37 (18.4) | 29 (23.4) | 79 | |
Bone | |||||
No | 102 (85.0) | 141 (70.1) | 75 (60.5) | 318 |
<0.001**
|
Yes | 18 (15.0) | 60 (29.9) | 49 (39.5) | 127 | |
Liver | |||||
No | 116 (96.7) | 181 (90.1) | 102 (82.3) | 399 |
<0.05*
|
Yes | 4 (3.3) | 20 (9.9) | 22 (17.7) | 46 | |
Adrenal gland | |||||
No | 115 (95.8) | 191 (95.0) | 116 (93.5) | 422 | 0.713 |
Yes | 5 (4.2) | 10 (5.0) | 8 (6.5) | 23 | |
Lymph node | |||||
No | 69 (57.5) | 69 (34.3) | 45 (36.3) | 183 |
<0.001**
|
Yes | 51 (42.5) | 132 (65.7) | 79 (63.7) | 262 | |
Intrapulmonary | |||||
No | 111 (92.5) | 165 (82.1) | 105 (84.7) | 381 |
<0.05*
|
Yes | 9 (7.5) | 36 (17.9) | 19 (15.3) | 64 | |
Pleural | |||||
No | 103 (85.8) | 161 (80.1) | 88 (71.0) | 352 |
<0.05*
|
Yes | 17 (14.2) | 40 (19.9) | 36 (29.0) | 93 | |
Mediastinal | |||||
No | 119 (99.2) | 195 (97.0) | 118 (95.2) | 432 | 0.178 |
Yes | 1 (0.8) | 6 (3.0) | 6 (4.8) | 13 | |
Peritoneum | |||||
No | 119 (99.2) | 186 (92.5) | 107 (86.3) | 412 |
<0.05*
|
Yes | 1 (0.8) | 15 (7.5) | 17 (13.7) | 33 |
No. (%) | |||||
---|---|---|---|---|---|
Neg | Moderate | High | Total |
P Value | |
(1–2 fold) | >2 fold | ||||
(n = 110) | (n = 70) | (n = 35) | (n = 215) | ||
Basic Characteristics | |||||
Age | |||||
< 45 years | 3 (2.7) | 2 (2.9) | 0 (0.0) | 5 | 0.622 |
45–60 years | 40 (36.4) | 23 (32.8) | 9 (25.7) | 72 | |
> 60 years | 67 (60.9) | 45 (64.3) | 26 (74.3) | 138 | |
Sex | |||||
Male | 101 (91.8) | 61 (87.1) | 30 (85.7) | 192 | 0.463 |
Female | 9 (8.2) | 9 (12.9) | 5 (14.3) | 23 | |
Stages | |||||
I + II | 26 (23.6) | 6 (8.6) | 1 (2.8) | 33 |
<0.05*
|
III + IV | 80 (72.7) | 62 (88.6) | 33 (94.4) | 175 | |
Unknown | 4 (3.7) | 2 (2.8) | 1 (2.8) | 7 | |
Smoke status | |||||
No | 22 (20.0) | 16 (22.9) | 9 (25.7) | 47 | 0.753 |
Yes | 88 (80.0) | 54 (77.1) | 26 (74.3) | 168 | |
Metastasis | |||||
Brain | |||||
No | 107 (97.3) | 62 (88.6) | 27 (77.1) | 196 |
<0.05*
|
Yes | 3 (2.7) | 8 (11.4) | 8 (22.9) | 19 | |
Bone | |||||
No | 100 (90.9) | 55 (78.6) | 27 (77.1) | 182 |
<0.05*
|
Yes | 10 (9.1) | 15 (21.4) | 8 (22.9) | 33 | |
Liver | |||||
No | 102 (92.7) | 61 (87.1) | 27 (77.1) | 190 | 0.062 |
Yes | 8 (7.3) | 9 (12.9) | 8 (22.9) | 25 | |
Adrenal gland | |||||
No | 106 (96.4) | 64 (91.4) | 32 (91.4) | 202 | 0.316 |
Yes | 4 (3.6) | 6 (8.6) | 3 (8.6) | 13 | |
Lymph node | |||||
No | 51 (46.4) | 19 (27.1) | 9 (25.7) | 79 |
<0.05*
|
Yes | 59 (53.6) | 51 (72.9) | 26 (74.3) | 136 | |
Intrapulmonary | |||||
No | 96 (87.3) | 58 (82.9) | 31 (88.6) | 185 | 0.632 |
Yes | 14 (12.7) | 12 (17.1) | 4 (11.4) | 30 | |
Pleural | |||||
No | 98 (89.1) | 59 (84.3) | 31 (88.6) | 188 | 0.622 |
Yes | 12 (10.9) | 11 (15.7) | 4 (11.4) | 27 | |
Mediastinal | |||||
No | 108 (98.2) | 61 (87.1) | 34 (97.1) | 203 |
<0.05*
|
Yes | 2 (1.8) | 9 (12.9) | 1 (2.9) | 12 | |
Peritoneum | |||||
No | 109 (99.1) | 61 (87.1) | 31 (88.6) | 201 |
<0.05*
|
Yes | 1 (0.9) | 9 (12.9) | 4 (11.4) | 14 |
Increased positive numbers of biomarkers as predictors of metastases
No. (%) | ||||||
---|---|---|---|---|---|---|
Neg | Single | Double | Triple | Total |
P Value | |
(1–10 fold) | >10 fold | |||||
(n = 37) | (n = 101) | (n = 172) | (n = 122) | (n = 432) | ||
Basic Characteristics | ||||||
Age | ||||||
< 45 | 2 (5.4) | 5 (5.0) | 12 (7.0) | 9 (7.4) | 28 | 0.057 |
45-60 | 22 (59.5) | 50 (49.5) | 61 (35.5) | 43 (35.2) | 176 | |
> 60 | 13 (35.1) | 46 (45.5) | 99 (57.6) | 70 (57.4) | 228 | |
Sex | ||||||
Male | 27 (73.0) | 71 (70.3) | 114 (66.3) | 84 (68.9) | 296 | 0.827 |
Female | 10 (27.0) | 30 (29.7) | 58 (33.7) | 38 (31.1) | 136 | |
Histological classification | ||||||
SCC | 12 (32.4) | 29 (28.7) | 49 (28.5) | 29 (23.8) | 119 | 0.772 |
ADC | 19 (51.4) | 53 (52.5) | 90 (52.3) | 63 (51.6) | 225 | |
SCLC | 3 (8.1) | 12 (11.9) | 24 (14) | 24 (19.7) | 63 | |
Others | 3 (8.1) | 7 (6.9) | 9 (5.2) | 6 (4.9) | 25 | |
Stages | ||||||
I | 5 (13.5) | 8 (7.9) | 5 (2.9) | 0 (0) | 18 |
<0.05*
|
II | 2 (5.4) | 6 (5.9) | 5 (2.9) | 4 (3.3) | 17 | |
III | 14 (37.8) | 34 (33.7) | 43 (25) | 37 (30.3) | 128 | |
IV | 14 (37.8) | 47 (46.5) | 109 (63.4) | 73 (59.8) | 243 | |
#Un. | 2 (5.4) | 6 (5.9) | 10 (5.8) | 8 (6.6) | 26 | |
Smoke status | ||||||
No | 16 (43.2) | 54 (53.5) | 73 (42.4) | 48 (39.3) | 191 | 0.178 |
Yes | 21 (56.8) | 47 (46.5) | 99 (57.6) | 74 (60.7) | 241 | |
Metastasis | ||||||
Brain | ||||||
No | 34 (91.9) | 91 (90.1) | 143 (83.1) | 103 (84.4) | 371 | 0.277 |
Yes | 3 (8.1) | 10 (9.9) | 29 (16.9) | 19 (15.6) | 61 | |
Bone | ||||||
No | 33 (89.2) | 87 (86.1) | 127 (73.8) | 88 (72.1) | 335 |
<0.05*
|
Yes | 4 (10.8) | 14 (13.9) | 45 (26.2) | 34 (27.9) | 97 | |
Liver | ||||||
No | 36 (97.3) | 94 (93.1) | 155 (90.1) | 106 (86.9) | 391 | 0.199 |
Yes | 1 (2.7) | 7 (6.9) | 17 (9.9) | 16 (13.1) | 41 | |
Adrenal gland | ||||||
No | 36 (97.3) | 98 (97) | 154 (89.5) | 117 (95.9) | 405 | 0.086 |
Yes | 1 (1.7) | 3 (3.0) | 18 (10.5) | 5 (4.1) | 27 | |
Lymph node | ||||||
No | 25 (67.6) | 45 (44.6) | 69 (40.1) | 32 (26.2) | 171 |
<0.001**
|
Yes | 12 (32.4) | 56 (55.4) | 103 (59.9) | 90 (73.8) | 261 | |
Intrapulmonary | ||||||
No | 33 (89.2) | 89 (88.1) | 149 (86.6) | 108 (88.5) | 379 | 0.950 |
Yes | 4 (10.8) | 12 (11.9) | 23 (13.4) | 14 (11.5) | 53 | |
Pleural | ||||||
No | 33 (89.2) | 89 (88.1) | 142 (82.6) | 104 (85.2) | 368 | 0.552 |
Yes | 4 (10.8) | 12 (11.9) | 30 (17.4) | 18 (14.8) | 64 | |
Mediastinal | ||||||
No | 37 (100) | 98 (97) | 169 (98.3) | 114 (93.4) | 418 | 0.080 |
Yes | 0 (0.0) | 3 (3.0) | 3 (1.7) | 8 (6.6) | 14 | |
Peritoneum | ||||||
No | 37 (100) | 98 (93.7) | 162 (94.2) | 112 (91.8) | 409 | 0.153 |
Yes | 0 (0.0) | 3 (6.3) | 10 (5.8) | 10 (8.2) | 23 | |
Validation group | ||||||
No. (%) | ||||||
Neg | Single | Double | Triple | Total |
P Value | |
(n = 27) | (n = 118) | (n = 161) | (n = 130) | (n = 436) | ||
Basic Characteristics | ||||||
Age | ||||||
2 (7.4) | 8 (6.8) | 10 (6.2) | 11 (8.5) | 31 | 0.733 | |
10 (37.0) | 46 (39.0) | 48 (29.8) | 45 (34.6) | 149 | ||
15 (55.6) | 64 (54.2) | 103 (64.0) | 74 (56.9) | 256 | ||
Sex | ||||||
18 (66.7) | 75 (63.6) | 116 (72.0) | 98 (75.4) | 307 | 0.204 | |
9 (33.3) | 43 (36.4) | 45 (28.0) | 32 (24.6) | 129 | ||
Histological classification | ||||||
7 (25.9) | 31 (26.3) | 37 (23) | 21 (16.2) | 96 | 0.386 | |
15 (55.6) | 57 (48.3) | 84 (52.2) | 64 (49.2) | 220 | ||
1 (3.7) | 5 (4.2) | 11 (6.8) | 7 (5.4) | 24 | ||
5 (18.5) | 12 (10.2) | 7 (4.3) | 24 (18.5) | 47 | ||
Stages | ||||||
5 (18.5) | 9 (7.6) | 5 (3.1) | 3 (2.3) | 22 |
<0.05*
| |
5 (18.5) | 16 (13.6) | 10 (6.2) | 7 (5.4) | 38 | ||
6 (22.2) | 26 (22.0) | 36 (22.4) | 21 (16.2) | 89 | ||
11 (40.7) | 58 (49.2) | 103 (64.0) | 90 (69.2) | 262 | ||
0 (0.0) | 9 (7.6) | 7 (4.3) | 9 (19.2) | 25 | ||
Smoke status | ||||||
15 (55.6) | 62 (52.5) | 65 (40.4) | 49 (37.7) | 191 |
<0.05*
| |
12 (44.4) | 56 (47.5) | 96 (59.6) | 81 (62.3) | 245 | ||
Metastasis | ||||||
Brain | ||||||
27 (100.0) | 107 (90.7) | 134 (83.2) | 110 (84.6) | 378 |
<0.05*
| |
0 (0.0) | 11 (9.3) | 27 (16.8) | 20 (15.4) | 58 | ||
Bone | ||||||
27 (100.0) | 103 (87.3) | 123 (76.4) | 87 (66.9) | 340 |
<0.001**
| |
0 (0.0) | 15 (12.7) | 38 (23.6) | 43 (33.1) | 96 | ||
Liver | ||||||
No | 26 (96.3) | 111 (94.1) | 140 (87.0) | 106 (81.5) | 383 |
<0.05*
|
Yes | 1 (3.7) | 7 (5.9) | 21 (13.0) | 24 (18.5) | 53 | |
Adrenal gland | ||||||
27 (100.0) | 111 (94.1) | 149 (92.5) | 122 (93.8) | 409 | 0.525 | |
0 (0.0) | 7 (5.9) | 12 (7.5) | 8 (6.2) | 27 | ||
Lymph node | ||||||
19 (70.4) | 58 (49.2) | 50 (31.1) | 40 (30.8) | 167 |
<0.001***
| |
8 (29.6) | 60 (50.8) | 111 (68.9) | 90 (69.2) | 269 | ||
Intrapulmonary | ||||||
26 (96.3) | 105 (89.0) | 130 (80.7) | 114 (87.7) | 375 | 0.064 | |
1 (3.7) | 13 (11.0) | 31 (19.3) | 16 (12.3) | 61 | ||
Pleural | ||||||
25 (92.6) | 107 (90.7) | 129 (80.1) | 104 (80.0) | 365 |
<0.05*
| |
2 (7.4) | 11 (9.3) | 32 (20.8) | 26 (20.0) | 71 | ||
Mediastinal | ||||||
27 (100.0) | 116 (98.3) | 152 (94.4) | 123 (94.6) | 418 | 0.229 | |
0 (0.0) | 2 (1.7) | 9 (5.6) | 7 (5.4) | 18 | ||
Peritoneum | ||||||
27 (100.0) | 110 (93.2) | 144 (89.4) | 118 (90.8) | 399 | 0.269 | |
0 (0.0) | 8 (6.8) | 17 (10.4) | 12 (9.2) | 37 |
CYFRA21-1 levels correlated with survival in ADC, SCC and SCLC
Multivariate Cox regression analysis to identify poor prognostic factors
Multivariate HR (95% CI) |
P value | |
---|---|---|
Age | ||
< 45 | 1[Reference] |
<0.001*
|
45–65 | 0.714 (0.513–0.994) | |
> 65 | 1.089 (0.793–1.495) | |
Sex | ||
Male | 1[Reference] | 0.529 |
Female | 0.942 (0.782–1.135) | |
Histological classification | ||
Squamous | 1[Reference] |
<0.05*
|
Adenocarcinoma | 1.113 (0.894–1.384) | |
SCLC | 0.970 (0.729–1.290) | |
Others | 1.654 (1.160–2.358) | |
Stages | ||
I | 1[Reference] |
<0.05*
|
II | 1.096 (0.624–1.925) | |
III | 1.218 (0.753–1.969) | |
IV | 1.976 (1.120–3.488) | |
Smoke statues | ||
No | 1[Reference] | 0.095 |
Yes | 0.823 (0.655–1.035) | |
CEA levels | ||
Neg | 1[Reference] | 0.233 |
Moderate | 1.171 (0.954–1.438) | |
High | 1.217 (0.945–1.567) | |
CYFRA levels | ||
Neg | 1[Reference] |
<0.001*
|
Moderate | 1.226 (0.977–1.537) | |
High | 1.647 (1.273–2.130) | |
NSE levels | ||
Neg | 1[Reference] |
<0.05*
|
Moderate | 1.010 (0.808–1.263) | |
High | 1.330 (1.032–1.715) | |
Metastasis | ||
No | 1[Reference] |
<0.05*
|
Yes | 1.291 (1.025–1.625 | |
Positive numbers | ||
Neg | 1[Reference] | 0.649 |
Single | 1.075 (0.806–1.434) | |
Double | 1.102 (0.898–1.353) | |
Triple | 1.086 (0.773–1.524) |
Adenocarcinoma | Squamous | SCLC | ||||
---|---|---|---|---|---|---|
(n = 445) | (n = 215) | (n = 159) | ||||
HR (95% CI) |
P value | HR (95% CI) |
P value | HR (95% CI) |
P value | |
Age | ||||||
< 45 | 1[Reference] |
<0.05*
| 1[Reference] |
<0.05*
| 1[Reference] | 0.104 |
45–65 | 0.733 (0.489–1.099) | 0.866 (0.259–2.895) | 0.769 (0.315–1.876) | |||
> 65 | 1.084 (0.741–1.587) | 1.712 (0.523–5.607) | 1.237 (0.510–3.003) | |||
Sex | ||||||
Male | 1[Reference] | 0.338 | 1[Reference] | 0.326 | 1[Reference] | 0.354 |
Female | 0.986 (0.715–1.122) | 1.312 (0.763–2.254) | 0.758 (0.421–1.363) | |||
Stages | ||||||
I + II | 1[Reference] | 0.415 | 1[Reference] | 0.475 | 1[Reference] | 0.902 |
III + IV | 1.703 (1.035–2.802) | 0.832 (0.495–1.399) | 1.091 (0.465–2.556) | |||
Smoke status | ||||||
No | 1[Reference] | 0.177 | 1[Reference] | 0.878 | 1[Reference] | 0.076 |
Yes | 0.807 (0.592–1.102) | 1.037 (0.651–1.651) | 0.518 (0.251–1.071) | |||
CEA levels | ||||||
Neg | 1[Reference] | 0.773 | 1[Reference] | 0.295 | 1[Reference] | 0.940 |
Moderate | 1.085 (0.679–1.736) | 1.244 (0.620–2.497) | 0.850 (0.317–2.280) | |||
High | 1.169 (0.713–1.916) | 0.700 (0.260–1.885) | 0.894 (0.271–2.942) | |||
CYFRA levels | ||||||
Neg | 1[Reference] |
<0.05*
| 1[Reference] | 0.195 | 1[Reference] |
<0.05*
|
Moderate | 1.161 (0.678–1.989) | 1.057 (0.511–2.185) | 1.365 (0.514–3.624) | |||
High | 1.860 (1.036–3.338) | 1.502 (0.673–3.353) | 0.907 (0.285–2.880) | |||
NSE levels | ||||||
Neg | 1[Reference] | 0.400 | 1[Reference] | 0.329 | 1[Reference] | 0.642 |
Moderate | 1.025 (0.727–1.446) | 1.025 (0.727–1.446) | 0.952 (0.390–2.323) | |||
High | 1.154 (0.777–1.714) | 1.154 (0.777–1.714) | 1.342 (0.590–3.052) | |||
Metastasis | ||||||
No | 1[Reference] | 0.477 | 1[Reference] |
<0.05*
| 1[Reference] |
<0.05*
|
Yes | 1.131 (0.806–1.585) | 1.682 (1.052–2.688) | 2.172 (1.180–3.998) | |||
Positive numbers | ||||||
Neg | 1[Reference] | 0.852 | 1[Reference] | 0.334 | 1[Reference] | 0.814 |
Single | 1.334 (0.672–2.649) | 0.748 (0.300–1.863) | 2.107 (0.460–9.644) | |||
Double | 1.491 (0.557–3.992) | 1.115 (0.327–3.803) | 2.247 (0.386–13.077) | |||
Triple | 1.652 (0.517–5.276) | 0.901 (0.183–4.449) | 2.508 (0.231–27.287) |
Multivariate HR (95% CI) |
P value | |
---|---|---|
A I + II | ||
Age | ||
< 45 | 1[Reference] | 0.405 |
45–65 | 0.390 (0.043–3.577) | |
> 65 | 0.664 (0.075–5.874) | |
Sex | ||
Male 1[Reference] | 0.997 | |
Female | 0.998 (0.358–2.779) | |
Smokes | ||
No | 1[Reference] | 0.828 |
Yes | 1.091 (0.496–2.400) | |
Histological classification | ||
SCC | 1[Reference] | 0.400 |
ADC | 0.692 (0.294–1.631) | |
SCLC | 1.000 (0.347–2.884) | |
Unknown | 0.943 (0.242–3.670) | |
Metastasis | ||
No | 1[Reference] | 0.992 |
Yes | 0.997 (0.505–1.967) | |
CEA | ||
Neg | 1[Reference] | 0.483 |
Moderate | 1.213 (0.555–2.651) | |
High | 1.442 (0.519–4.009) | |
NSE | ||
Neg | 1[Reference] | 0.592 |
Moderate | 1.064 (0.542–2.090) | |
High | 0.718 (0.214–2.411) | |
CYFRA | ||
Neg | 1[Reference] |
<0.05*
|
Moderate | 1.696 (0.848–3.390) | |
High | 3.666 (1.095–12.279) | |
B. Stage III | ||
Age | ||
< 45 | 1[Reference] | 0.147 |
45–65 | 0.492 (0.189–1.283) | |
> 65 | 1.230 (0.491–3.083) | |
Sex | ||
Male | 1[Reference] | 0.934 |
Female | 0.976 (0.555–1.718) | |
Smokes | ||
No | 1[Reference] | 0.758 |
Yes | 1.075 (0.680–1.699) | |
Histological classification | ||
SCC | 1[Reference] | 0.272 |
ADC | 0.974 (0.624–1.521) | |
SCLC | 0.796 (0.445–1.424) | |
Unknown | 1.439 (0.752–2.756) | |
Metastasis | ||
No | 1[Reference] | 0.094 |
Yes | 1.444 (0.939–0.221) | |
CEA | ||
Neg | 1[Reference] | 0.423 |
Moderate | 1.047 (0.715–1.532) | |
High | 1.260 (0.716–2.218) | |
NSE | ||
Neg | 1[Reference] | 0.165 |
Moderate | 0.738 (0.480–1.134) | |
High | 1.333 (0.796–2.323) | |
CYFRA | ||
Neg | 1[Reference] |
<0.05*
|
Moderate | 1.279 (0.844–1.938) | |
High | 1.919 (1.200–3.071) | |
C Stage IV | ||
Age | ||
< 45 | 1[Reference] | 0.285 |
45–65 | 0.818 (0.566–1.182) | |
> 65 | 1.052 (0.739–1.499) | |
Sex | ||
Male | 1[Reference] | 0.452 |
Female | 1.125 (0.827–1.531) | |
Smokes | ||
No | 1[Reference] | 0.130 |
Yes | 1.261 (0.934–1.702) | |
Histological classification | ||
SCC | 1[Reference] | 0.090 |
ADC | 1.299 (0.960–1.756) | |
SCLC | 1.182 (0.801–1.744) | |
Unknown | 1.811 (1.082–3.030) | |
Metastasis | ||
No | 1[Reference] |
<0.05*
|
Yes | 1.494 (1.034–2.160) | |
CEA | ||
Neg | 1[Reference] | 0.332 |
Moderate | 1.132 (0.881–1.456) | |
High | 1.074 (0.802–1.439) | |
NSE | ||
Neg | 1[Reference] | 0.060 |
Moderate | 1.042 (0.806–1.346) | |
High | 1.319 (0.989–1.759) | |
CYFRA | ||
Neg | 1[Reference] |
<0.05*
|
Moderate | 1.107 (0.822–1.489) | |
High | 1.473 (1.056–2.053) |